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New loci associated...
New loci associated with kidney function and chronic kidney disease
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Köttgen, Anna (author)
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Pattaro, Cristian (author)
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Böger, Carsten A. (author)
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show more...
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Fuchsberger, Christian (author)
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Olden, Matthias (author)
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Glazer, Nicole L. (author)
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Parsa, Afshin (author)
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Gao, Xiaoyi (author)
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Yang, Qiong (author)
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Smith, Albert V. (author)
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O'Connell, Jeffrey R. (author)
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Li, Man (author)
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Schmidt, Helena (author)
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Tanaka, Toshiko (author)
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Isaacs, Aaron (author)
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Ketkar, Shamika (author)
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Hwang, Shih-Jen (author)
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Johnson, Andrew D. (author)
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Dehghan, Abbas (author)
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Teumer, Alexander (author)
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Pare, Guillaume (author)
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Atkinson, Elizabeth J. (author)
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Zeller, Tanja (author)
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Lohman, Kurt (author)
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Cornelis, Marilyn C. (author)
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Probst-Hensch, Nicole M. (author)
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Kronenberg, Florian (author)
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Toenjes, Anke (author)
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Hayward, Caroline (author)
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Aspelund, Thor (author)
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Eiriksdottir, Gudny (author)
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Launer, Lenore J. (author)
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Harris, Tamara B. (author)
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Rampersaud, Evadnie (author)
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Mitchell, Braxton D. (author)
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Arking, Dan E. (author)
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Boerwinkle, Eric (author)
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Struchalin, Maksim (author)
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Cavalieri, Margherita (author)
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Singleton, Andrew (author)
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Giallauria, Francesco (author)
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Metter, Jeffrey (author)
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de Boer, Ian H. (author)
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Haritunians, Talin (author)
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Lumley, Thomas (author)
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Siscovick, David (author)
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Psaty, Bruce M. (author)
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Zillikens, M. Carola (author)
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Oostra, Ben A. (author)
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Feitosa, Mary (author)
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Province, Michael (author)
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de Andrade, Mariza (author)
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Turner, Stephen T. (author)
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Schillert, Arne (author)
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Ziegler, Andreas (author)
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Wild, Philipp S. (author)
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Schnabel, Renate B. (author)
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Wilde, Sandra (author)
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Munzel, Thomas (author)
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Leak, Tennille S. (author)
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Illig, Thomas (author)
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Klopp, Norman (author)
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Meisinger, Christa (author)
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Wichmann, H-Erich (author)
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Koenig, Wolfgang (author)
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Zgaga, Lina (author)
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Zemunik, Tatijana (author)
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Kolcic, Ivana (author)
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Minelli, Cosetta (author)
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Hu, Frank B. (author)
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- Johansson, Åsa (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Igl, Wilmar (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Zaboli, Ghazal (author)
- Uppsala universitet,Institutionen för genetik och patologi
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Wild, Sarah H. (author)
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Wright, Alan F. (author)
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Campbell, Harry (author)
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Ellinghaus, David (author)
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Schreiber, Stefan (author)
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Aulchenko, Yurii S. (author)
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Felix, Janine F. (author)
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Rivadeneira, Fernando (author)
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Uitterlinden, Andre G. (author)
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Hofman, Albert (author)
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Imboden, Medea (author)
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Nitsch, Dorothea (author)
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Brandstaetter, Anita (author)
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Kollerits, Barbara (author)
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Kedenko, Lyudmyla (author)
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Maegi, Reedik (author)
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Stumvoll, Michael (author)
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Kovacs, Peter (author)
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Boban, Mladen (author)
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Campbell, Susan (author)
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Endlich, Karlhans (author)
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Voelzke, Henry (author)
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Kroemer, Heyo K. (author)
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Nauck, Matthias (author)
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Voelker, Uwe (author)
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Polasek, Ozren (author)
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Vitart, Veronique (author)
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Badola, Sunita (author)
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Parker, Alexander N. (author)
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Ridker, Paul M. (author)
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Kardia, Sharon L. R. (author)
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Blankenberg, Stefan (author)
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Liu, Yongmei (author)
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Curhan, Gary C. (author)
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Franke, Andre (author)
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Rochat, Thierry (author)
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Paulweber, Bernhard (author)
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Prokopenko, Inga (author)
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Wang, Wei (author)
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Gudnason, Vilmundur (author)
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Shuldiner, Alan R. (author)
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Coresh, Josef (author)
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Schmidt, Reinhold (author)
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Ferrucci, Luigi (author)
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Shlipak, Michael G. (author)
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van Duijn, Cornelia M. (author)
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Borecki, Ingrid (author)
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Kraemer, Bernhard K. (author)
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Rudan, Igor (author)
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- Gyllensten, Ulf (author)
- Uppsala universitet,Institutionen för genetik och patologi
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Wilson, James F. (author)
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Witteman, Jacqueline C. (author)
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Pramstaller, Peter P. (author)
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Rettig, Rainer (author)
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Hastie, Nick (author)
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Chasman, Daniel I. (author)
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Kao, W. H. (author)
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Heid, Iris M. (author)
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Fox, Caroline S. (author)
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(creator_code:org_t)
- 2010-04-11
- 2010
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:5, s. 376-384
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m2; n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide–significant loci (P < 5 × 10−8) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
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- By the author/editor
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Köttgen, Anna
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Pattaro, Cristia ...
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Böger, Carsten A ...
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Fuchsberger, Chr ...
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Olden, Matthias
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Glazer, Nicole L ...
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show more...
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Parsa, Afshin
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Gao, Xiaoyi
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Yang, Qiong
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Smith, Albert V.
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O'Connell, Jeffr ...
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Li, Man
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Schmidt, Helena
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Tanaka, Toshiko
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Isaacs, Aaron
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Ketkar, Shamika
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Hwang, Shih-Jen
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Johnson, Andrew ...
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Dehghan, Abbas
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Teumer, Alexande ...
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Pare, Guillaume
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Atkinson, Elizab ...
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Zeller, Tanja
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Lohman, Kurt
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Cornelis, Marily ...
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Probst-Hensch, N ...
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Kronenberg, Flor ...
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Toenjes, Anke
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Hayward, Carolin ...
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Aspelund, Thor
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Eiriksdottir, Gu ...
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Launer, Lenore J ...
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Harris, Tamara B ...
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Rampersaud, Evad ...
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Mitchell, Braxto ...
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Arking, Dan E.
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Boerwinkle, Eric
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Struchalin, Maks ...
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Cavalieri, Margh ...
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Singleton, Andre ...
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Giallauria, Fran ...
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Metter, Jeffrey
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de Boer, Ian H.
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Haritunians, Tal ...
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Lumley, Thomas
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Siscovick, David
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Psaty, Bruce M.
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Zillikens, M. Ca ...
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Oostra, Ben A.
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Feitosa, Mary
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Province, Michae ...
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de Andrade, Mari ...
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Turner, Stephen ...
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Schillert, Arne
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Ziegler, Andreas
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Wild, Philipp S.
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Schnabel, Renate ...
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Wilde, Sandra
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Munzel, Thomas
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Leak, Tennille S ...
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Illig, Thomas
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Klopp, Norman
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Meisinger, Chris ...
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Wichmann, H-Eric ...
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Koenig, Wolfgang
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Zgaga, Lina
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Zemunik, Tatijan ...
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Kolcic, Ivana
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Minelli, Cosetta
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Hu, Frank B.
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Johansson, Åsa
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Igl, Wilmar
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Zaboli, Ghazal
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Wild, Sarah H.
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Wright, Alan F.
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Campbell, Harry
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Ellinghaus, Davi ...
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Schreiber, Stefa ...
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Aulchenko, Yurii ...
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Felix, Janine F.
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Rivadeneira, Fer ...
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Uitterlinden, An ...
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Hofman, Albert
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Imboden, Medea
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Nitsch, Dorothea
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Brandstaetter, A ...
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Kollerits, Barba ...
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Kedenko, Lyudmyl ...
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Maegi, Reedik
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Stumvoll, Michae ...
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Kovacs, Peter
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Boban, Mladen
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Campbell, Susan
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Endlich, Karlhan ...
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Voelzke, Henry
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Kroemer, Heyo K.
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Nauck, Matthias
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Voelker, Uwe
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Polasek, Ozren
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Vitart, Veroniqu ...
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Badola, Sunita
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Parker, Alexande ...
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Ridker, Paul M.
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Kardia, Sharon L ...
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Blankenberg, Ste ...
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Liu, Yongmei
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Curhan, Gary C.
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Franke, Andre
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Rochat, Thierry
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Paulweber, Bernh ...
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Prokopenko, Inga
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Wang, Wei
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Gudnason, Vilmun ...
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Shuldiner, Alan ...
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Coresh, Josef
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Schmidt, Reinhol ...
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Ferrucci, Luigi
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Shlipak, Michael ...
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van Duijn, Corne ...
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Borecki, Ingrid
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Kraemer, Bernhar ...
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Rudan, Igor
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Gyllensten, Ulf
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Wilson, James F.
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Witteman, Jacque ...
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Pramstaller, Pet ...
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Rettig, Rainer
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Hastie, Nick
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Chasman, Daniel ...
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Kao, W. H.
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Heid, Iris M.
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Fox, Caroline S.
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show less...
- Articles in the publication
-
Nature Genetics
- By the university
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Uppsala University