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CPT1a-Dependent Lon...
CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets
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Briant, L. J. B. (författare)
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Dodd, M. S. (författare)
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Chibalina, M. V. (författare)
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Rorsman, N. J. G. (författare)
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Johnson, P. R. V. (författare)
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Carmeliet, P. (författare)
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- Rorsman, Patrik, 1959 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Knudsen, J. G. (författare)
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: Cell Reports. - : Elsevier BV. - 2211-1247. ; 23:11, s. 3300-3311
- Relaterad länk:
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http://www.cell.com/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Glucagon, the principal hyperglycemic hormone, is secreted from pancreatic islet a cells as part of the counter-regulatory response to hypoglycemia. Hence, secretory output from a cells is under high demand in conditions of low glucose supply. Many tissues oxidize fat as an alternate energy substrate. Here, we show that glucagon secretion in low glucose conditions is maintained by fatty acid metabolism in both mouse and human islets, and that inhibiting this metabolic pathway profoundly decreases glucagon output by depolarizing alpha cell membrane potential and decreasing action potential amplitude. We demonstrate, by using experimental and computational approaches, that this is not mediated by the K-ATP channel, but instead due to reduced operation of the Na+-K+ pump. These data suggest that counter-regulatory secretion of glucagon is driven by fatty acid metabolism, and that the Na+-K+ pump is an important ATP-dependent regulator of alpha cell function.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- sensitive k+ channels
- human skeletal-muscle
- alpha-cells
- beta-cells
- glucose-production
- diabetes-mellitus
- energy-metabolism
- gene-expression
- atp channels
- delta-cells
- Cell Biology
- baulny ho
- 1995
- journal of pediatrics
- v127
- p723
- rich je
- 1973
- science
- v182
- p171
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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