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Identification of s...
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
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- Ji, Xuemei (author)
- Dartmouth College
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Bosse, Yohan (author)
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Landi, Maria Teresa (author)
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show more...
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Gui, Jiang (author)
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Xiao, Xiangjun (author)
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Qian, David (author)
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Joubert, Philippe (author)
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Lamontagne, Maxime (author)
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Li, Yafang (author)
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Gorlov, Ivan (author)
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de Biasi, Mariella (author)
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Han, Younghun (author)
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Gorlova, Olga (author)
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Hung, Rayjean J. (author)
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Wu, Xifeng (author)
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Mckay, James (author)
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Zong, Xuchen (author)
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Carreras-Torres, Robert (author)
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Christiani, David C. (author)
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Caporaso, Neil (author)
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Johansson, Mattias (author)
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Liu, Geoffrey (author)
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Bojesen, Stig E. (author)
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Le Marchand, Loic (author)
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Albanes, Demetrios (author)
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Bickeboeller, Heike (author)
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Aldrich, Melinda C. (author)
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Bush, William S. (author)
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Tardon, Adonina (author)
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Rennert, Gad (author)
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Chen, Chu (author)
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Teare, M. Dawn (author)
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Field, John K. (author)
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Kiemeney, Lambertus A. (author)
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Lazarus, Philip (author)
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Haugen, Aage (author)
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Lam, Stephen (author)
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Schabath, Matthew B. (author)
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Andrew, Angeline S. (author)
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Shen, Hongbing (author)
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Hong, Yun-Chul (author)
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Yuan, Jian-Min (author)
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Bertazzi, Pier A. (author)
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Pesatori, Angela C. (author)
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Ye, Yuanqing (author)
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Diao, Nancy (author)
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Su, Li (author)
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Zhang, Ruyang (author)
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Brhane, Yonathan (author)
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Leighl, Natasha (author)
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Johansen, Jakob S. (author)
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Mellemgaard, Anders (author)
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Saliba, Walid (author)
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Haiman, Christopher (author)
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Wilkens, Lynne (author)
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Fernandez-Somoano, Ana (author)
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Fernandez-Tardon, Guillermo (author)
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van der Heijden, Erik H. F. M. (author)
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Kim, Jin Hee (author)
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Dai, Juncheng (author)
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Hu, Zhibin (author)
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Davies, Michael P. A. (author)
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Marcus, Michael W. (author)
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- Brunnström, Hans (author)
- Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Melander, Olle (author)
- Lund University,Lunds universitet
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Muller, David C. (author)
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- Overvad, Kim (author)
- Lund University
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Trichopoulou, Antonia (author)
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Tumino, Rosario (author)
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Doherty, Jennifer (author)
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Goodman, Gary E. (author)
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Cox, Angela (author)
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Taylor, Fiona (author)
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Woll, Penella (author)
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Brueske, Irene (author)
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Manz, Judith (author)
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Muley, Thomas (author)
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Risch, Angela (author)
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Rosenberger, Albert (author)
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- Grankvist, Kjell (author)
- Umeå universitet,Klinisk kemi
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- Johansson, Mikael (author)
- Umeå universitet,Onkologi
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Shepherd, Frances (author)
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Tsao, Ming-Sound (author)
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Arnold, Susanne M. (author)
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Haura, Eric B. (author)
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Bolca, Ciprian (author)
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Holcatova, Ivana (author)
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Janout, Vladimir (author)
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Kontic, Milica (author)
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Lissowska, Jolanta (author)
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Mukeria, Anush (author)
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Ognjanovic, Simona (author)
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Orlowski, Tadeusz M. (author)
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Scelo, Ghislaine (author)
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Swiatkowska, Beata (author)
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Zaridze, David (author)
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Bakke, Per (author)
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Skaug, Vidar (author)
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Zienolddiny, Shanbeh (author)
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Duell, Eric J. (author)
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Butler, Lesley M. (author)
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Koh, Woon-Puay (author)
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Gao, Yu-Tang (author)
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Houlston, Richard (author)
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McLaughlin, John (author)
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Stevens, Victoria (author)
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Nickle, David C. (author)
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Obeidat, Ma'en (author)
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Timens, Wim (author)
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Zhu, Bin (author)
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Song, Lei (author)
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Artigas, Maria Soler (author)
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Tobin, Martin D. (author)
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Wain, Louise V. (author)
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Gu, Fangyi (author)
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Byun, Jinyoung (author)
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Kamal, Ahsan (author)
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Zhu, Dakai (author)
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Tyndale, Rachel F. (author)
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Wei, Wei-Qi (author)
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Chanock, Stephen (author)
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Brennan, Paul (author)
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- Amos, Christopher I. (author)
- Dartmouth College
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(creator_code:org_t)
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et al
- 2018-08-13
- 2018
- English.
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In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 9, s. 1-15
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ji, Xuemei
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Bosse, Yohan
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Landi, Maria Ter ...
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Gui, Jiang
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Xiao, Xiangjun
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Qian, David
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show more...
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Joubert, Philipp ...
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Lamontagne, Maxi ...
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Li, Yafang
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Gorlov, Ivan
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de Biasi, Mariel ...
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Han, Younghun
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Gorlova, Olga
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Hung, Rayjean J.
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Wu, Xifeng
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Mckay, James
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Zong, Xuchen
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Carreras-Torres, ...
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Christiani, Davi ...
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Caporaso, Neil
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Johansson, Matti ...
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Liu, Geoffrey
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Bojesen, Stig E.
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Le Marchand, Loi ...
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Albanes, Demetri ...
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Bickeboeller, He ...
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Aldrich, Melinda ...
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Bush, William S.
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Tardon, Adonina
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Rennert, Gad
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Chen, Chu
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Teare, M. Dawn
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Field, John K.
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Kiemeney, Lamber ...
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Lazarus, Philip
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Haugen, Aage
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Lam, Stephen
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Schabath, Matthe ...
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Andrew, Angeline ...
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Shen, Hongbing
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Hong, Yun-Chul
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Yuan, Jian-Min
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Bertazzi, Pier A ...
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Pesatori, Angela ...
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Ye, Yuanqing
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Diao, Nancy
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Su, Li
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Zhang, Ruyang
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Brhane, Yonathan
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Leighl, Natasha
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Johansen, Jakob ...
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Mellemgaard, And ...
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Saliba, Walid
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Haiman, Christop ...
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Wilkens, Lynne
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Fernandez-Somoan ...
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Fernandez-Tardon ...
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van der Heijden, ...
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Kim, Jin Hee
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Dai, Juncheng
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Hu, Zhibin
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Davies, Michael ...
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Marcus, Michael ...
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Brunnström, Hans
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Manjer, Jonas
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Melander, Olle
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Muller, David C.
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Overvad, Kim
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Trichopoulou, An ...
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Tumino, Rosario
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Doherty, Jennife ...
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Goodman, Gary E.
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Cox, Angela
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Taylor, Fiona
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Woll, Penella
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Brueske, Irene
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Manz, Judith
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Muley, Thomas
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Risch, Angela
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Rosenberger, Alb ...
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Grankvist, Kjell
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Johansson, Mikae ...
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Shepherd, France ...
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Tsao, Ming-Sound
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Arnold, Susanne ...
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Haura, Eric B.
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Bolca, Ciprian
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Holcatova, Ivana
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Janout, Vladimir
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Kontic, Milica
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Lissowska, Jolan ...
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Mukeria, Anush
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Ognjanovic, Simo ...
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Orlowski, Tadeus ...
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Scelo, Ghislaine
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Swiatkowska, Bea ...
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Zaridze, David
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Bakke, Per
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Skaug, Vidar
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Zienolddiny, Sha ...
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Duell, Eric J.
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Butler, Lesley M ...
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Koh, Woon-Puay
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Gao, Yu-Tang
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Houlston, Richar ...
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McLaughlin, John
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Stevens, Victori ...
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Nickle, David C.
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Obeidat, Ma'en
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Timens, Wim
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Zhu, Bin
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Song, Lei
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Artigas, Maria S ...
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Tobin, Martin D.
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Wain, Louise V.
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Gu, Fangyi
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Byun, Jinyoung
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Kamal, Ahsan
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Zhu, Dakai
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Tyndale, Rachel ...
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Wei, Wei-Qi
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Chanock, Stephen
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Brennan, Paul
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Amos, Christophe ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Communica ...
- By the university
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Umeå University
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Lund University