Sökning: (WFRF:(Siscovick David)) lar1:(gu) > A genome-wide assoc...
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000 | 09556naa a2201597 4500 | |
001 | oai:gup.ub.gu.se/161244 | |
003 | SwePub | |
008 | 240910s2012 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:609e539b-1012-40ad-b9c6-35ecbfa9f16c | |
009 | oai:DiVA.org:uu-181141 | |
024 | 7 | a https://gup.ub.gu.se/publication/1612442 URI |
024 | 7 | a https://doi.org/10.1371/journal.pgen.10028052 DOI |
024 | 7 | a https://lup.lub.lu.se/record/30732192 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1811412 URI |
040 | a (SwePub)gud (SwePub)lud (SwePub)uu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Coviello, Andrea D4 aut |
245 | 1 0 | a A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation. |
264 | c 2012-07-19 | |
264 | 1 | b Public Library of Science (PLoS),c 2012 |
520 | a Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide association study (GWAS) meta-analysis of 21,791 individuals from 10 epidemiologic studies and validated these findings in 7,046 individuals in an additional six studies. We identified twelve genomic regions (SNPs) associated with circulating SHBG concentrations. Loci near the identified SNPs included SHBG (rs12150660, 17p13.1, p=1.8×10(-106)), PRMT6 (rs17496332, 1p13.3, p=1.4×10(-11)), GCKR (rs780093, 2p23.3, p=2.2×10(-16)), ZBTB10 (rs440837, 8q21.13, p=3.4×10(-09)), JMJD1C (rs7910927, 10q21.3, p=6.1×10(-35)), SLCO1B1 (rs4149056, 12p12.1, p=1.9×10(-08)), NR2F2 (rs8023580, 15q26.2, p=8.3×10(-12)), ZNF652 (rs2411984, 17q21.32, p=3.5×10(-14)), TDGF3 (rs1573036, Xq22.3, p=4.1×10(-14)), LHCGR (rs10454142, 2p16.3, p=1.3×10(-07)), BAIAP2L1 (rs3779195, 7q21.3, p=2.7×10(-08)), and UGT2B15 (rs293428, 4q13.2, p=5.5×10(-06)). These genes encompass multiple biologic pathways, including hepatic function, lipid metabolism, carbohydrate metabolism and T2D, androgen and estrogen receptor function, epigenetic effects, and the biology of sex steroid hormone-responsive cancers including breast and prostate cancer. We found evidence of sex-differentiated genetic influences on SHBG. In a sex-specific GWAS, the loci 4q13.2-UGT2B15 was significant in men only (men p=2.5×10(-08), women p=0.66, heterogeneity p=0.003). Additionally, three loci showed strong sex-differentiated effects: 17p13.1-SHBG and Xq22.3-TDGF3 were stronger in men, whereas 8q21.12-ZBTB10 was stronger in women. Conditional analyses identified additional signals at the SHBG gene that together almost double the proportion of variance explained at the locus. Using an independent study of 1,129 individuals, all SNPs identified in the overall or sex-differentiated or conditional analyses explained ∼15.6% and ∼8.4% of the genetic variation of SHBG concentrations in men and women, respectively. The evidence for sex-differentiated effects and allelic heterogeneity highlight the importance of considering these features when estimating complex trait variance. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng |
700 | 1 | a Haring, Robin4 aut |
700 | 1 | a Wellons, Melissa4 aut |
700 | 1 | a Vaidya, Dhananjay4 aut |
700 | 1 | a Lehtimäki, Terho4 aut |
700 | 1 | a Keildson, Sarah4 aut |
700 | 1 | a Lunetta, Kathryn L4 aut |
700 | 1 | a He, Chunyan4 aut |
700 | 1 | a Fornage, Myriam4 aut |
700 | 1 | a Lagou, Vasiliki4 aut |
700 | 1 | a Mangino, Massimo4 aut |
700 | 1 | a Onland-Moret, N Charlotte4 aut |
700 | 1 | a Chen, Brian4 aut |
700 | 1 | a Eriksson, Joelu Gothenburg University,Göteborgs universitet,Institutionen för medicin,Centre for Bone and Arthritis Research,Institute of Medicine4 aut0 (Swepub:gu)xerjoe |
700 | 1 | a Garcia, Melissa4 aut |
700 | 1 | a Liu, Yong Mei4 aut |
700 | 1 | a Koster, Annemarie4 aut |
700 | 1 | a Lohman, Kurt4 aut |
700 | 1 | a Lyytikäinen, Leo-Pekka4 aut |
700 | 1 | a Petersen, Ann-Kristin4 aut |
700 | 1 | a Prescott, Jennifer4 aut |
700 | 1 | a Stolk, Lisette4 aut |
700 | 1 | a Vandenput, Liesbeth,d 1974u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Centre for Bone and Arthritis Research,Institute of Medicine4 aut0 (Swepub:gu)xvanli |
700 | 1 | a Wood, Andrew R4 aut |
700 | 1 | a Zhuang, Wei Vivian4 aut |
700 | 1 | a Ruokonen, Aimo4 aut |
700 | 1 | a Hartikainen, Anna-Liisa4 aut |
700 | 1 | a Pouta, Anneli4 aut |
700 | 1 | a Bandinelli, Stefania4 aut |
700 | 1 | a Biffar, Reiner4 aut |
700 | 1 | a Brabant, Georg4 aut |
700 | 1 | a Cox, David G4 aut |
700 | 1 | a Chen, Yuhui4 aut |
700 | 1 | a Cummings, Steven4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Gunter, Marc J4 aut |
700 | 1 | a Hankinson, Susan E4 aut |
700 | 1 | a Martikainen, Hannu4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Homuth, Georg4 aut |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Jansson, John-Olov,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Centre for Bone and Arthritis Research,Institute of Medicine4 aut0 (Swepub:gu)xjanjo |
700 | 1 | a Johnson, Andrew D4 aut |
700 | 1 | a Karasik, David4 aut |
700 | 1 | a Karlsson, Magnusu Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups4 aut0 (Swepub:lu)orto-mka |
700 | 1 | a Kettunen, Johannes4 aut |
700 | 1 | a Kiel, Douglas P4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Liu, Jingmin4 aut |
700 | 1 | a Ljunggren, Östenu Uppsala universitet,Metabola bensjukdomar4 aut0 (Swepub:uu)osteljun |
700 | 1 | a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xlomat |
700 | 1 | a Maggio, Marcello4 aut |
700 | 1 | a Markus, Marcello R P4 aut |
700 | 1 | a Mellström, Dan,d 1945u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xmelda |
700 | 1 | a Miljkovic, Iva4 aut |
700 | 1 | a Mirel, Daniel4 aut |
700 | 1 | a Nelson, Sarah4 aut |
700 | 1 | a Morin Papunen, Laure4 aut |
700 | 1 | a Peeters, Petra H M4 aut |
700 | 1 | a Prokopenko, Inga4 aut |
700 | 1 | a Raffel, Leslie4 aut |
700 | 1 | a Reincke, Martin4 aut |
700 | 1 | a Reiner, Alex P4 aut |
700 | 1 | a Rexrode, Kathryn4 aut |
700 | 1 | a Rivadeneira, Fernando4 aut |
700 | 1 | a Schwartz, Stephen M4 aut |
700 | 1 | a Siscovick, David4 aut |
700 | 1 | a Soranzo, Nicole4 aut |
700 | 1 | a Stöckl, Doris4 aut |
700 | 1 | a Tworoger, Shelley4 aut |
700 | 1 | a Uitterlinden, André G4 aut |
700 | 1 | a van Gils, Carla H4 aut |
700 | 1 | a Vasan, Ramachandran S4 aut |
700 | 1 | a Wichmann, H-Erich4 aut |
700 | 1 | a Zhai, Guangju4 aut |
700 | 1 | a Bhasin, Shalender4 aut |
700 | 1 | a Bidlingmaier, Martin4 aut |
700 | 1 | a Chanock, Stephen J4 aut |
700 | 1 | a De Vivo, Immaculata4 aut |
700 | 1 | a Harris, Tamara B4 aut |
700 | 1 | a Hunter, David J4 aut |
700 | 1 | a Kähönen, Mika4 aut |
700 | 1 | a Liu, Simin4 aut |
700 | 1 | a Ouyang, Pamela4 aut |
700 | 1 | a Spector, Tim D4 aut |
700 | 1 | a van der Schouw, Yvonne T4 aut |
700 | 1 | a Viikari, Jorma4 aut |
700 | 1 | a Wallaschofski, Henri4 aut |
700 | 1 | a McCarthy, Mark I4 aut |
700 | 1 | a Frayling, Timothy M4 aut |
700 | 1 | a Murray, Anna4 aut |
700 | 1 | a Franks, Steve4 aut |
700 | 1 | a Järvelin, Marjo-Riitta4 aut |
700 | 1 | a de Jong, Frank H4 aut |
700 | 1 | a Raitakari, Olli4 aut |
700 | 1 | a Teumer, Alexander4 aut |
700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xohlcl |
700 | 1 | a Murabito, Joanne M4 aut |
700 | 1 | a Perry, John R B4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för medicin4 org |
773 | 0 | t PLoS geneticsd : Public Library of Science (PLoS)g 8:7q 8:7x 1553-7404x 1553-7390 |
856 | 4 | u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002805&type=printable |
856 | 4 | u https://portal.research.lu.se/files/2275197/3563301.pdfx primaryx freey FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1371/journal.pgen.1002805x freey FULLTEXT |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:553175/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://gup.ub.gu.se/publication/161244 |
856 | 4 8 | u https://doi.org/10.1371/journal.pgen.1002805 |
856 | 4 8 | u https://lup.lub.lu.se/record/3073219 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-181141 |
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