Search: (WFRF:(Tiensuu Janson Eva)) pers:(Lannfelt Lars) >
Smoking is associat...
Smoking is associated with mosaic loss of chromosome Y
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- Dumanski, Jan P. (author)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Uppsala University,Uppsala University (SE)
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- Rasi, Chiara (author)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Uppsala University,Uppsala University (SE)
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- Lönn, Mikael (author)
- Södertörns högskola,Biologi,Södertörn University, School of Life Sciences, Biology, Huddinge, Sweden,Södertörns högskola, Biologi,Södertörn University (SE)
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- Davies, Hanna (author)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Uppsala University,Uppsala University (SE)
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- Ingelsson, Martin (author)
- Uppsala universitet,Geriatrik,Uppsala University,Uppsala University (SE)
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- Giedraitis, Vilmantas (author)
- Uppsala universitet,Geriatrik,Uppsala University,Uppsala University (SE)
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- Lannfelt, Lars (author)
- Karolinska Institutet,Uppsala universitet,Geriatrik,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Uppsala University,Karolinska Institutet (SE),Uppsala University (SE)
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- Magnusson, Patrik K E (author)
- Karolinska Institutet,Department of Economics, Stockholm School of Economics, Stockholm, Sweden,Karolinska Institutet (SE)
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- Lindgren, Cecilia M (author)
- Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK;Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA,University of Oxford (GB)
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- Morris, Andrew P (author)
- Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK;Department of Biostatistics, University of Liverpool, Liverpool, UK,University of Oxford (GB)
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- Cesarini, David (author)
- Center for Experimental Social Science, New York University, New York, NY 10012, USA
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- Johannesson, Magnus (author)
- Stockholm School of Economics,Handelshögskolan i Stockholm
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- Tiensuu Janson, Eva (author)
- Uppsala universitet,Endokrin Onkologi,Uppsala University,Uppsala University (SE)
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi,Uppsala University
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- Pedersen, Nancy L (author)
- Karolinska Institutet
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- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Uppsala University,Karolinska Institutet (SE)
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- Forsberg, Lars A. (author)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Uppsala University,Uppsala University (SE)
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2015
- 2015
- English.
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 347:6217, s. 81-83
- Related links:
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Abstract
Subject headings
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- Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared to females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% CI = 2.8-6.7; ULSAM: OR = 2.4, 95% CI = 1.6-3.6; and PIVUS: OR = 3.5, 95% CI = 1.4-8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Dumanski, Jan P.
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Rasi, Chiara
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Lönn, Mikael
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Davies, Hanna
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Ingelsson, Marti ...
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Giedraitis, Vilm ...
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show more...
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Lannfelt, Lars
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Magnusson, Patri ...
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Lindgren, Cecili ...
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Morris, Andrew P
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Cesarini, David
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Johannesson, Mag ...
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Tiensuu Janson, ...
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Lind, Lars
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Pedersen, Nancy ...
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Ingelsson, Erik
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Forsberg, Lars A ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Science
- By the university
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Södertörn University
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Uppsala University
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Karolinska Institutet
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University of Gävle
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Stockholm School of Economics