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Detection of Neoehr...
Detection of Neoehrlichia mikurensis DNA in blood donors in southeastern Sweden
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- Labbé Sandelin, Lisa, 1977- (författare)
- Uppsala universitet,Infektionsmedicin,Department of Communicable Diseases and Disease Control, Region Kalmar County, Kalmar, Sweden,Region Kalmar County, Sweden;Uppsala University, Sweden,Dept Communicable Dis & Dis Control, Sweden; Uppsala Univ, Sweden
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- Olofsson, Jenny (författare)
- Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Ctr Ecol & Evolut Microbial Model Syst EEMiS,Centre for Ecology and Evolution in Microbial Model Systems, Linnaeus University, Kalmar,Linnaeus Univ, Sweden
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- Tolf, Conny (författare)
- Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Ctr Ecol & Evolut Microbial Model Syst EEMiS,Centre for Ecology and Evolution in Microbial Model Systems, Linnaeus University, Kalmar, Sweden,Linnaeus Univ, Sweden
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- Rohlén, Louise (författare)
- Department of Infectious Diseases, Kalmar County Hospital, Kalmar, Sweden,Kalmar Cty Hosp, Sweden
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- Brudin, Lars (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Dept Clin Physiol, Sweden
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- Tjernberg, Ivar (författare)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Dept Clin Chem & Transfus Med, Sweden
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- Lindgren, Per-Eric (författare)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Cty Hosp Ryhov, Sweden
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- Olsen, Björn (författare)
- Uppsala universitet,Infektionsmedicin,Uppsala University, Sweden,Uppsala Univ, Sweden
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- Waldenström, Jonas, 1975- (författare)
- Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Ctr Ecol & Evolut Microbial Model Syst EEMiS,Centre for Ecology and Evolution in Microbial Model Systems, Linnaeus University, Kalmar, Sweden,Linnaeus Univ, Sweden
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(creator_code:org_t)
- 2022-06-20
- 2022
- Engelska.
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Ingår i: Infectious Diseases. - : Taylor & Francis Group. - 2374-4235 .- 2374-4243. ; 54:10, s. 748-759
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background The tick-borne bacterium Neoehrlichia mikurensis can cause persistent asymptomatic bloodstream infections, but transfusion-mediated transmission has not been reported. This study aimed to investigate the prevalence of N. mikurensis in blood donors, and recipients of blood components from N. mikurensis-positive donors were traced.Methods In 2019 and 2021, 1007 blood donors were recruited. Participants completed a questionnaire and additional blood samples were collected during blood donation. Detection of N. mikurensis was performed by PCR followed by sequencing. Positive donors were interviewed and retested. Look-back was performed on positive donations and on all subsequent donations.Results N. mikurensis was detected in 7/1006 (0.7%) donors. A total of 380/1005 (38%) donors reported at least one noticed tick bite during the current season. The questionnaire could not detect any differences between negative and positive N. mikurensis-donors. Two of the positive donors were still positive on days 318 and 131 after the index donation, respectively. One donor with persistent N. mikurensis in blood experienced slight fatigue. All other had no symptoms attributable to neoehrlichiosis. Look-back included ten donations and 20 blood components. Eight components were discarded, and 12 recipients of N. mikurensis-positive donations were identified. PCR was negative in seven recipients. Five recipients had died, but their medical records gave no evidence for neoehrlichiosis.Conclusions Although N. mikurensis was found in 0.7% of blood donors, transfusion-mediated infection was not detected, despite several recipients being at high risk for severe neoehrlichiosis. The results warrant further studies as well as raised clinical awareness.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- Neoehrlichia
- tick-borne infections
- transfusion-transmitted infections
- blood donors
- immunosuppression
- emerging infectious diseases
- blood safety
- Infektionssjukdomar
- Infectious Diseases
- Zoonotisk ekologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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