SwePub
Sök i LIBRIS databas

  Utökad sökning

(WFRF:(Wang Gang)) srt2:(2015-2019) lar1:(oru)
 

Sökning: (WFRF:(Wang Gang)) srt2:(2015-2019) lar1:(oru) > RBBP6 increases rad...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005969naa a2200553 4500
001oai:DiVA.org:oru-64711
003SwePub
008180202s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-647112 URI
0247 a https://doi.org/10.1111/cas.135162 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Xiao, Chaou Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut
2451 0a RBBP6 increases radioresistance and serves as a therapeutic target for preoperative radiotherapy in colorectal cancer
264 c 2018-03-10
264 1b Blackwell Publishing,c 2018
338 a print2 rdacarrier
520 a Radiotherapy (RT) can be used as preoperative treatment to downstage initially unresectable locally rectal carcinoma, but the radioresistance and recurrence remain significant problems. Retinoblastoma binding protein 6 (RBBP6) has been implicated in the regulation of cell cycle, apoptosis and chemoresistance both in vitro and in vivo. This study investigated whether the inhibition of RBBP6 expression would improve radiosensitivity in human colorectal cancer cells. After SW620 and HT29 cells were exposed to radiation, the levels of RBBP6 mRNA and protein increased over time in both two cells. Moreover, a significant reduction in clonogenic survival and a decrease in cell viability in parallel with an obvious increase in cell apoptosis were demonstrated in irradiated RBBP6-knockdown cells. Besides, transfection with RBBP6 shRNA improved levels of G2-M phase arrest which blocked the cells in a more radiosensitive period of the cell cycle. These observations indicated that cell cycle and apoptosis mechanisms may be connected with tumor cell survival following radiotherapy. In vivo, tumor growth rate of nude mice in RBBP6-knockdown group was significantly slower than that in other groups. These results indicated that RBBP6 overexpression could resist colorectal cancer cells against radiation by regulating cell cycle and apoptosis pathways, and inhibition of RBBP6 could enhance radiosensitivity of human colorectal cancer.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Apoptosis
653 a Cell cycle
653 a Preoperative radiotherapy
653 a RBBP6
653 a Rectal cancer
7001 a Wang, Yupengu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut
7001 a Zheng, Miaou Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut
7001 a Chen, Jianu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut
7001 a Song, Guoheu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut
7001 a Zhou, Zhijieu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut
7001 a Zhou, Chongzhiu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut
7001 a Sun, Xingu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut
7001 a Zhong, Linu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut
7001 a Ding, Erxunu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut
7001 a Zhang, Yiu Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut
7001 a Yang, Liuu Department of Obstetrics and Gynecology, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 aut
7001 a Wu, Gangu Department of General Surgery, Henan Provincial People's Hospital People's Hospital, Zhengzhou University, Zhengzhou, People's Republic of China4 aut
7001 a Xu, Shifengu Department of General Surgery, Shandong Provincial Hospital Affiliated, Shandong University, Jinan, People's Republic of China4 aut
7001 a Zhang, Hong,d 1957-u Örebro universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:oru)hzg
7001 a Wang, Xiaoliangu Department of General Surgery, Shanghai General Hospital School of Medicine, Jiao Tong University, Shanghai, People's Republic of China4 aut
7102 a Department of General Surgery, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of Chinab Department of Obstetrics and Gynecology, Shanghai General Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China4 org
7730 t Cancer Scienced : Blackwell Publishingg 109:4, s. 1075-1087q 109:4<1075-1087x 1347-9032x 1349-7006
8564 u https://doi.org/10.1111/cas.13516y Fulltext
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.13516
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-64711
8564 8u https://doi.org/10.1111/cas.13516

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy