(hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) hsv:(Neurologi)) lar1:(gih)
Sökning: (hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) hsv:(Neurologi)) lar1:(gih) > (2015-2019) > Neurocognitive intr...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04231naa a2200541 4500 | |
| 001 | oai:DiVA.org:gih-8027 | |
| 003 | SwePub | |
| 008 | 231222s2015 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:132208586 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-80272 URI |
| 024 | 7 | a https://doi.org/10.1017/S00332917150009262 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1322085862 URI |
| 040 | a (SwePub)gihd (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Gallagher, P4 aut |
| 245 | 1 0 | a Neurocognitive intra-individual variability in mood disorders :b effects on attentional response time distributions. |
| 264 | 1 | c 2015 |
| 338 | a print2 rdacarrier | |
| 520 | a BACKGROUND: Attentional impairment is a core cognitive feature of major depressive disorder (MDD) and bipolar disorder (BD). However, little is known of the characteristics of response time (RT) distributions from attentional tasks. This is crucial to furthering our understanding of the profile and extent of cognitive intra-individual variability (IIV) in mood disorders.METHOD: A computerized sustained attention task was administered to 138 healthy controls and 158 patients with a mood disorder: 86 euthymic BD, 33 depressed BD and 39 medication-free MDD patients. Measures of IIV, including individual standard deviation (iSD) and coefficient of variation (CoV), were derived for each participant. Ex-Gaussian (and Vincentile) analyses were used to characterize the RT distributions into three components: mu and sigma (mean and standard deviation of the Gaussian portion of the distribution) and tau (the 'slow tail' of the distribution).RESULTS: Compared with healthy controls, iSD was increased significantly in all patient samples. Due to minimal changes in average RT, CoV was only increased significantly in BD depressed patients. Ex-Gaussian modelling indicated a significant increase in tau in euthymic BD [Cohen's d = 0.39, 95% confidence interval (CI) 0.09-0.69, p = 0.011], and both sigma (d = 0.57, 95% CI 0.07-1.05, p = 0.025) and tau (d = 1.14, 95% CI 0.60-1.64, p < 0.0001) in depressed BD. The mu parameter did not differ from controls.CONCLUSIONS: Increased cognitive variability may be a core feature of mood disorders. This is the first demonstration of differences in attentional RT distribution parameters between MDD and BD, and BD depression and euthymia. These data highlight the utility of applying measures of IIV to characterize neurocognitive variability and the great potential for future application. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a Attention | |
| 653 | a bipolar disorder | |
| 653 | a ex-Gaussian analyses | |
| 653 | a major depression | |
| 653 | a neuropsychology | |
| 653 | a variability | |
| 700 | 1 | a Nilsson, Jonnau Karolinska Institutet,Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa,Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.4 aut0 (Swepub:gih)jonna.nilsson |
| 700 | 1 | a Finkelmeyer, A4 aut |
| 700 | 1 | a Goshawk, M4 aut |
| 700 | 1 | a Macritchie, K A4 aut |
| 700 | 1 | a Lloyd, A J4 aut |
| 700 | 1 | a Thompson, J M4 aut |
| 700 | 1 | a Porter, R J4 aut |
| 700 | 1 | a Young, A H4 aut |
| 700 | 1 | a Ferrier, I N4 aut |
| 700 | 1 | a McAllister-Williams, R H4 aut |
| 700 | 1 | a Watson, S4 aut |
| 710 | 2 | a Gymnastik- och idrottshögskolanb Institutionen för fysisk aktivitet och hälsa4 org |
| 773 | 0 | t Psychological Medicineg 45:14, s. 2985-97q 45:14<2985-97x 0033-2917x 1469-8978 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-8027 |
| 856 | 4 8 | u https://doi.org/10.1017/S0033291715000926 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:132208586 |
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