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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 08963naa a2200805 4500 | |
| 001 | oai:DiVA.org:oru-47352 | |
| 003 | SwePub | |
| 008 | 160108s2016 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:ce882173-09fc-4163-9b30-2d40f1f2a5ce | |
| 009 | oai:prod.swepub.kib.ki.se:132594617 | |
| 009 | oai:DiVA.org:liu-112705 | |
| 009 | oai:DiVA.org:uu-274273 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-473522 URI |
| 024 | 7 | a https://doi.org/10.1136/gutjnl-2014-3083632 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/48159492 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1325946172 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1127052 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2742732 URI |
| 040 | a (SwePub)orud (SwePub)lud (SwePub)kid (SwePub)liud (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Münch, Andreasu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet,Magtarmmedicinska kliniken,Linkoping Univ, Fac Hlth Sci, Dept Clin & Expt Med, Div Gastroenterol & Hepatol, S-58185 Linkoping, Sweden.4 aut0 (Swepub:liu)andsa76 |
| 245 | 1 0 | a Low-dose budesonide for maintenance of clinical remission in collagenous colitis :b a randomised, placebo-controlled, 12-month trial |
| 264 | c 2014-11-25 | |
| 264 | 1 | b BMJ Publishing Group,c 2016 |
| 338 | a print2 rdacarrier | |
| 500 | a Funding Agency:Dr Falk Pharma GmbH, Freiburg, Germany | |
| 500 | a Funding agencies: Dr Falk Pharma GmbH, Freiburg, Germany | |
| 520 | a Objective: This 1-year study aimed to assess low-dose budesonide therapy for maintenance of clinical remission in patients with collagenous colitis.Design: A prospective, randomised, placebo-controlled study beginning with an 8-week open-label induction phase in which patients with histologically confirmed active collagenous colitis received budesonide (Budenofalk, 9 mg/day initially, tapered to 4.5 mg/day), after which 92 patients in clinical remission were randomised to budesonide (mean dose 4.5 mg/day; Budenofalk 3 mg capsules, two or one capsule on alternate days) or placebo in a 12-month double-blind phase with 6 months treatment-free follow-up. Primary endpoint was clinical remission throughout the double-blind phase.Results: Clinical remission during open-label treatment was achieved by 84.5% (93/110 patients). The median time to remission was 10.5 days (95% CI (9.0 to 14.0 days)). The maintenance of clinical remission at 1 year was achieved by 61.4% (27/44 patients) in the budesonide group versus 16.7% (8/48 patients) receiving placebo (treatment difference 44.5% in favour of budesonide; 95% CI (26.9% to 62.7%), p<0.001). Health-related quality of life was maintained during the 12-month double-blind phase in budesonide-treated patients. During treatment-free follow-up, 82.1% (23/28 patients) formerly receiving budesonide relapsed after study drug discontinuation. Low-dose budesonide over 1 year resulted in few suspected adverse drug reactions (7/44 patients), all non-serious.Conclusions: Budesonide at a mean dose of 4.5 mg/day maintained clinical remission for at least 1 year in the majority of patients with collagenous colitis and preserved health-related quality of life without safety concerns. Treatment extension with low-dose budesonide beyond 1 year may be beneficial given the high relapse rate after budesonide discontinuation. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 700 | 1 | a Bohr, Johan,d 1957-u Region Örebro län,Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden,Örebro University Hospital, and School of Health and Medical Sciences, Örebro University, Sweden,Univ Orebro, Orebro Univ Hosp, Dept Gastroenterol, SE-70182 Orebro, Sweden.;Univ Orebro, Sch Hlth & Med Sci, SE-70182 Orebro, Sweden.4 aut0 (Swepub:oru)jbr |
| 700 | 1 | a Miehlke, Stephanu Centre for Digestive Disease, Hamburg, Germany,Ctr Digest Dis, Hamburg, Germany.4 aut |
| 700 | 1 | a Benoni, Ceciliau Lund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups,University Hospital, Malmö, Sweden,Univ Hosp, Dept Gastroenterol, Malmo, Sweden.4 aut0 (Swepub:lu)medf-cbe |
| 700 | 1 | a Olesen, Martinu Department of Pathology, University Hospital, Malmö, Sweden,Univ Hosp, Dept Pathol, Malmo, Sweden.4 aut |
| 700 | 1 | a Öst, Åkeu Department of Pathology and Cytology, Aleris Medilab, Täby, Sweden,Aleris Medilab, Dept Pathol & Cytol, Taby, Sweden.4 aut |
| 700 | 1 | a Strandberg, Larsu Regional Hospital, Falun, Sweden,Reg Hosp, Falun, Sweden.4 aut |
| 700 | 1 | a Hellström, Per M.u Uppsala universitet,Gastroenterologi/hepatologi4 aut0 (Swepub:uu)perhe742 |
| 700 | 1 | a Hertervig, Eriku Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,University Hospital, Lund, Sweden,Univ Lund Hosp, Dept Gastroenterol, S-22185 Lund, Sweden.4 aut0 (Swepub:lu)med-ehe |
| 700 | 1 | a Armerding, Peteru Gastroenterology, Private Practice, Berlin, Germany4 aut |
| 700 | 1 | a Stehlik, Jiriu Department of Gastroenterology, Regional Hospital, Usti nad Labem, Czech Republic,Reg Hosp, Dept Gastroenterol, Usti Nad Labem, Czech Republic.4 aut |
| 700 | 1 | a Lindberg, Gregeru Karolinska Institutet,Karolinska University Hospital Huddinge, Stockholm, Sweden,Karolinska Univ Hosp Huddinge, Ctr Digest Dis, Stockholm, Sweden.4 aut |
| 700 | 1 | a Björk, Janu Karolinska Institutet,Karolinska University Hospital Solna, Stockholm, Sweden,Karolinska Univ Hosp Solna, Ctr Digest Dis, Stockholm, Sweden.4 aut |
| 700 | 1 | a Lapidus, Annikau Department of Gastroenterology, Ersta Hospital, Stockholm, Sweden,Ersta Hosp, Dept Gastroenterol, Stockholm, Sweden.4 aut |
| 700 | 1 | a Löfberg, Robertu IBD Unit, Department of Gastroenterology, Sophiahemmet, Stockholm, Sweden,Sophiahemmet, Dept Gastroenterol, IBD Unit, Stockholm, Sweden.4 aut |
| 700 | 1 | a Bonderup, Oleu Department of Gastroenterology, Regional Hospital, Silkeborg, Denmark,Reg Hosp, Dept Gastroenterol, Silkeborg, Denmark.4 aut |
| 700 | 1 | a Avnström, Sörenu Department of Gastroenterology, Amager Hospital, Copenhagen, Denmark,Amager Hosp, Dept Gastroenterol, Copenhagen, Denmark.4 aut |
| 700 | 1 | a Rössle, Martinu Gastroenterology, Private Practice, Freiburg, Germany4 aut |
| 700 | 1 | a Dilger, Karinu Dr Falk, Pharma GmBH, Freiburg, Germany4 aut |
| 700 | 1 | a Mueller, Ralphu Dr Falk, Pharma GmBH, Freiburg, Germany4 aut |
| 700 | 1 | a Greinwald, Rolandu Dr Falk, Pharma GmBH, Freiburg, Germany4 aut |
| 700 | 1 | a Tysk, Curt,d 1949-u Region Örebro län,Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden,Örebro University Hospital, and School of Health and Medical Sciences, Örebro University, Sweden,Univ Orebro, Orebro Univ Hosp, Dept Gastroenterol, SE-70182 Orebro, Sweden.;Univ Orebro, Sch Hlth & Med Sci, SE-70182 Orebro, Sweden.4 aut0 (Swepub:oru)ctk |
| 700 | 1 | a Ström, Magnusu Linköpings universitet,Östergötlands Läns Landsting,Magtarmmedicinska kliniken,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Linkoping Univ, Fac Hlth Sci, Dept Clin & Expt Med, Div Gastroenterol & Hepatol, S-58185 Linkoping, Sweden.4 aut0 (Swepub:liu)magst47 |
| 710 | 2 | a Linköpings universitetb Avdelningen för inflammationsmedicin4 org |
| 773 | 0 | t Gutd : BMJ Publishing Groupg 65:1, s. 47-56q 65:1<47-56x 0017-5749x 1468-3288 |
| 856 | 4 | u https://doi.org/10.1136/gutjnl-2014-308363y Fulltext |
| 856 | 4 | u https://gut.bmj.com/content/gutjnl/65/1/47.full.pdf |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/25425655?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1136/gutjnl-2014-308363y FULLTEXT |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:912697/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-47352 |
| 856 | 4 8 | u https://doi.org/10.1136/gutjnl-2014-308363 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/4815949 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:132594617 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-112705 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-274273 |
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