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Interaction between...
Interaction between gad65 antibodies and dietary fish intake or plasma phospholipid n-3 polyunsaturated fatty acids on incident adult-onset diabetes : The epic-interact study
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- Löfvenborg, Josefin E. (author)
- Karolinska Institutet,Karolinska Institute
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- Carlsson, Sofia (author)
- Karolinska Institutet,Karolinska Institute
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- Andersson, Tomas (author)
- Karolinska Institutet,Stockholm County Council,Karolinska Institute
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- Hampe, Christiane S. (author)
- University of Washington
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- Koulman, Albert (author)
- University of Cambridge
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- Lopez, María Dolores Chirlaque (author)
- Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP),University of Murcia
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- Jakszyn, Paula (author)
- L'Hospitalet de Llobregat, Barcelona,Ramon Llull University
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- Katzke, Verena A. (author)
- German Cancer Research Centre
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- Kühn, Tilman (author)
- German Cancer Research Centre
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- Kyrø, Cecilie (author)
- Danish Cancer Society
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- Masala, Giovanna (author)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Nilsson, Peter M. (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Overvad, Kim (author)
- Aalborg University Hospital,Aarhus University
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- Panico, Salvatore (author)
- University of Naples Federico II
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- Sánchez, Maria Jose (author)
- University of Granada,Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
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- Van Der Schouw, Yvonne (author)
- University Medical Center Utrecht
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- Schulze, Matthias B. (author)
- University of Potsdam,German Center for Diabetes Research,German Institute of Human Nutrition
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- Tjønneland, Anne (author)
- Danish Cancer Society,University of Copenhagen
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- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer, World Health Organization
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- Riboli, Elio (author)
- Imperial College London
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- Forouhi, Nita G. (author)
- University of Cambridge
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- Sharp, Stephen J. (author)
- University of Cambridge
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- Rolandsson, Olov (author)
- Umeå universitet,Umeå University,Allmänmedicin
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- Wareham, Nicholas J. (author)
- University of Cambridge
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(creator_code:org_t)
- 2020-12-10
- 2021
- English 9 s.
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In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 44:2, s. 416-424
- Related links:
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http://dx.doi.org/10...
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https://care.diabete...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
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- OBJECTIVE: Islet autoimmunity is associated with diabetes incidence. We investigated whether there was an interaction between dietary fish intake or plasma phospholipid n-3 polyunsaturated fatty acid (PUFA) concentration with the 65-kDa isoform of GAD (GAD65) antibody positivity on the risk of developing adult-onset diabetes. RESEARCH DESIGN AND METHODS: We used prospective data on 11,247 incident cases of adult-onset diabetes and 14,288 noncases from the EPIC-InterAct case-cohort study conducted in eight European countries. Baseline plasma samples were analyzed for GAD65 antibodies and phospholipid n-3 PUFAs. Adjusted hazard ratios (HRs) for incident diabetes in relation to GAD65 antibody status and tertiles of plasma phospholipid n-3 PUFA or fish intake were estimated using Prentice-weighted Cox regression. Additive (proportion attributable to interaction [AP]) and multiplicative interactions between GAD65 antibody positivity (≥65 units/mL) and low fish/n-3 PUFA were assessed. RESULTS: The hazard of diabetes in antibody-positive individuals with low intake of total and fatty fish, respectively, was significantly elevated (HR 2.52 [95% CI 1.76-3.63] and 2.48 [1.79-3.45]) compared with people who were GAD65 antibody negative and had high fish intake, with evidence of additive (AP 0.44 [95% CI 0.16-0.72] and 0.48 [0.24-0.72]) and multiplicative (P 5 0.0465 and 0.0103) interactions. Individuals with high GAD65 antibody levels (≥167.5 units/mL) and low total plasma phospholipid n-3 PUFAs had a more than fourfold higher hazard of diabetes (HR 4.26 [2.70-6.72]) and an AP of 0.46 (0.12-0.80) compared with antibody-negative individuals with high n-3 PUFAs. CONCLUSIONS: High fish intake or relative plasma phospholipid n-3 PUFA concentrations may partially counteract the increased diabetes risk conferred by GAD65 antibody positivity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Löfvenborg, Jose ...
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Carlsson, Sofia
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Andersson, Tomas
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Hampe, Christian ...
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Koulman, Albert
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Lopez, María Dol ...
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show more...
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Jakszyn, Paula
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Katzke, Verena A ...
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Kühn, Tilman
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Kyrø, Cecilie
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Masala, Giovanna
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Nilsson, Peter M ...
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Overvad, Kim
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Panico, Salvator ...
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Sánchez, Maria J ...
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Van Der Schouw, ...
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Schulze, Matthia ...
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Tjønneland, Anne
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Weiderpass, Elis ...
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Riboli, Elio
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Forouhi, Nita G.
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Sharp, Stephen J ...
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Rolandsson, Olov
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Wareham, Nichola ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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Diabetes Care
- By the university
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Lund University
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Umeå University
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Karolinska Institutet