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The association of circulating adiponectin levels with pancreatic cancer risk: A study within the prospective EPIC cohort
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Grote, Verena A. (author)
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Rohrmann, Sabine (author)
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Dossus, Laure (author)
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show more...
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Nieters, Alexandra (author)
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Halkjær, Jytte (author)
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Tjønneland, Anne (author)
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Overvad, Kim (author)
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Stegger, Jakob (author)
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Chabbert-Buffet, Nathalie (author)
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Boutron-Ruault, Marie Christine (author)
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Clavel-Chapelon, Françoise (author)
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Teucher, Birgit (author)
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Becker, Susen (author)
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Montonen, Jukka (author)
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Boeing, Heiner (author)
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Trichopoulou, Antonia (author)
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Lagiou, Pagona (author)
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Trichopoulos, Dimitrios (author)
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Palli, Domenico (author)
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Sieri, Sabina (author)
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Tumino, Rosario (author)
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Vineis, Paolo (author)
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Mattiello, Amalia (author)
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Argüelles, Marcial (author)
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Duell, Eric J. (author)
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Molina-Montes, Esther (author)
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Larrañaga, Nerea (author)
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Chirlaque, María Dolores (author)
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Gurrea, Aurelio Barricarte (author)
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Jeurnink, Suzanne M. (author)
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Peeters, Petra H.M. (author)
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- Ye, Weimin (author)
- Karolinska Institutet
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- Sund, Malin (author)
- Umeå universitet,Kirurgi,Institutionen för folkhälsa och klinisk medicin
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- Lindkvist, Björn (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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- Johansen, Dorthe (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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Khaw, Kay Tee (author)
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Wareham, Nick (author)
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Crowe, Francesca L. (author)
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Romieu, Isabelle (author)
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Rinaldi, Sabina (author)
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Jenab, Mazda (author)
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Romaguera, Dora (author)
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Michaud, Dominique S. (author)
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Riboli, Elio (author)
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Bas Bueno-De-Mesquita, H. (author)
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Kaaks, Rudolf (author)
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(creator_code:org_t)
- 2011-09-17
- 2012
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 130, s. 2428-2437
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Abstract
Subject headings
Close
- Excess body weight and type 2 diabetes mellitus, risk factors of pancreatic cancer, are characterized by decreased levels of adiponectin. In addition to anti-inflammatory and anti-proliferative actions, adiponectin has an important role in regulating glucose metabolism, i.e., decreasing circulating blood glucose levels. Prospectively, hyperglycemia has been associated with risk of pancreatic cancer. The aim of this study was to investigate the association of pre-diagnostic adiponectin levels with pancreatic cancer risk. We conducted a case-control study nested within European Prospective Investigation into Cancer and Nutrition. Blood samples of 452 pancreatic cancer cases and 452 individually matched controls were analyzed by immunoassays. Multivariate conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Overall, adiponectin showed no association with pancreas cancer risk; however, among never smokers, higher circulating levels of adiponectin were associated with a reduction in pancreatic cancer risk (OR = 0.44 [95% CI 0.23-0.82] for highest vs. lowest quartile), whereas among current smokers there was no significant association (OR = 1.59 [95% CI 0.67-3.76] for highest vs. lowest quartile; p-trend = 0.530; p-interaction = 0.309). In our study, lower adiponectin concentrations may be associated with the development of pancreatic cancer among never smokers, whereas the only other prospective study being conducted so far showed a decrease in risk among male smokers. Therefore, further studies are needed to clarify the role of adiponectin in pancreatic cancer development. © 2011 UICC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- adiponectin
- cohort study
- EPIC
- pancreatic cancer
- adiponectin
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Grote, Verena A.
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Rohrmann, Sabine
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Dossus, Laure
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Nieters, Alexand ...
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Halkjær, Jytte
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Tjønneland, Anne
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show more...
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Overvad, Kim
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Stegger, Jakob
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Chabbert-Buffet, ...
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Boutron-Ruault, ...
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Clavel-Chapelon, ...
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Teucher, Birgit
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Becker, Susen
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Montonen, Jukka
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Boeing, Heiner
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Trichopoulou, An ...
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Lagiou, Pagona
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Trichopoulos, Di ...
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Palli, Domenico
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Sieri, Sabina
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Tumino, Rosario
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Vineis, Paolo
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Mattiello, Amali ...
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Argüelles, Marci ...
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Duell, Eric J.
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Molina-Montes, E ...
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Larrañaga, Nerea
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Chirlaque, María ...
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Gurrea, Aurelio ...
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Jeurnink, Suzann ...
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Peeters, Petra H ...
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Ye, Weimin
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Sund, Malin
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Lindkvist, Björn
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Johansen, Dorthe
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Khaw, Kay Tee
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Wareham, Nick
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Crowe, Francesca ...
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Romieu, Isabelle
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Rinaldi, Sabina
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Jenab, Mazda
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Romaguera, Dora
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Michaud, Dominiq ...
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Riboli, Elio
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Bas Bueno-De-Mes ...
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Kaaks, Rudolf
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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University of Gothenburg
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Lund University
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Karolinska Institutet
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Umeå University