Sökning: (swepub) pers:(Ågren Hans)
> (2000-2004) >
Compliance with SSR...
Compliance with SSRI medication during 6 months of treatment for major depression : an evaluation by determination of repeated serum drug concentrations
-
- Reis, Margareta (författare)
- Lund University,Lunds universitet,Linköpings universitet,Klinisk farmakologi,Hälsouniversitetet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
-
- Åberg-Wistedt, Anna (författare)
- Karolinska Institute, Department of Psychiatry, Stockholm, Sweden
-
- Ågren, Hans (författare)
- Karolinska Institute, Neurote Department, Division of Psychiatry, Huddinge, Sweden
-
visa fler...
-
- Åkerblad, Ann-Charlotte (författare)
- Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden
-
- Bengtsson, Finn, 1956- (författare)
- Linköpings universitet,Klinisk farmakologi,Hälsouniversitetet
-
visa färre...
-
(creator_code:org_t)
- 2004-04-15
- 2004
- Engelska.
-
Ingår i: Journal of Affective Disorders. - : Elsevier BV. - 0165-0327 .- 1573-2517. ; 82:3, s. 443-446
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: A recent estimation in a psychiatric cohort showed numbers of noncompliance between 10% and 60%. Therapeutic drug monitoring (TDM) is one method assessing compliance by analysis of drug concentration in the blood.Method: During a 24-week phase IV clinical trial, five repeated serum samples of sertraline (SERT) and N-desmethylsertraline (DSERT), trough values in steady state, were collected per patient. Previous results show that the intraindividual variation over time of the ratio DSERT/SERT is low. Hence, we hypothesized that significant partial noncompliance could be scrutinized further by an assessment of the DSERT/SERT ratio. The main aim was to test the applicability of a novel type of TDM procedure based on repeated metabolite/parent compound ratio measurements.Result: 9.4% of the per-protocol population in the trial (n=96) were in either hidden total (n=4) or hidden partial (n=5) noncompliance. Only by using the novel TDM ratio screening method could a majority of these patients be identified.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- SSRI
- depression
- sertraline
- MEDICINE
- MEDICIN
- sertraline
- SSRI
- depression
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas