Search: AMNE:(MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Anestesi och intensivvård)
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Antibiotic use duri...
Antibiotic use during coronavirus disease 2019 intensive care unit shape multidrug resistance bacteriuria : A Swedish longitudinal prospective study
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- Karlsson, Philip A. (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Anestesiologi och intensivvård
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- Pärssinen, Julia (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Danielsson, Erik A. (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Fatsis-Kavalopoulos, Nikos (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Frithiof, Robert (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Hultström, Michael, 1978- (author)
- Uppsala universitet,Integrativ Fysiologi,Anestesiologi och intensivvård
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- Lipcsey, Miklós (author)
- Uppsala universitet,Hedenstiernalaboratoriet
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- Järhult, Josef D., 1975- (author)
- Uppsala universitet,Infektionsmedicin
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- Wang, Helen (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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(creator_code:org_t)
- 2023-02-07
- 2023
- English.
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In: Frontiers in Medicine. - : Frontiers Media S.A.. - 2296-858X. ; 10
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Objectives: High frequency of antimicrobial prescription and the nature of prolonged illness in COVID-19 increases risk for complicated bacteriuria and antibiotic resistance. We investigated risk factors for bacteriuria in the ICU and the correlation between antibiotic treatment and persistent bacteria.Methods: We conducted a prospective longitudinal study with urine from indwelling catheters of 101 ICU patients from Uppsala University Hospital, Sweden. Samples were screened and isolates confirmed with MALDI-TOF and whole genome sequencing. Isolates were analyzed for AMR using broth microdilution. Clinical data were assessed for correlation with bacteriuria.Results: Length of stay linearly correlated with bacteriuria (R2 = 0.99, p ≤ 0.0001). 90% of patients received antibiotics, primarily the beta-lactams (76%) cefotaxime, piperacillin-tazobactam, and meropenem. We found high prevalence of Enterococcus (42%) being associated with increased cefotaxime prescription. Antibiotic-susceptible E. coli were found to cause bacteriuria despite concurrent antibiotic treatment when found in co-culture with Enterococcus.Conclusion: Longer stays in ICUs increase the risk for bacteriuria in a predictable manner. Likely, high use of cefotaxime drives Enterococcus prevalence, which in turn permit co-colonizing Gram-negative bacteria. Our results suggest biofilms in urinary catheters as a reservoir of pathogenic bacteria with the potential to develop and disseminate AMR.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- UTI
- ICU–intensive care unit
- COVID-19
- MDR–(multidrug resistance)
- AMR
- antibiotic treatment
- catheters
- Anestesiologi och intensivvård
- Anaesthesiology and Intensive Care
- Mikrobiologi
- Microbiology
- Epidemiologi
- Epidemiology
- Urologi
- Urology
- Pharmaceutical Microbiology
- Farmaceutisk mikrobiologi
- Klinisk bakteriologi
- Clinical Bacteriology
- Klinisk farmakologi
- Clinical Pharmacology
Publication and Content Type
- ref (subject category)
- art (subject category)
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