Sökning: L773:0007 1048 OR L773:1365 2141 >
Improved outcome af...
Improved outcome after relapse in children with acute myeloid leukaemia.
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- Abrahamsson, Jonas, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Clausen, Niels (författare)
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- Gustafsson, Göran (författare)
- Karolinska Institutet
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Hovi, Liisa (författare)
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Jonmundsson, Gudmundur (författare)
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Zeller, Bernward (författare)
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- Forestier, Erik (författare)
- Umeå universitet,Pediatrik
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- Heldrup, Jesper (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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Hasle, Henrik (författare)
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(creator_code:org_t)
- Wiley, 2007
- 2007
- Engelska.
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Ingår i: British journal of haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 136:2, s. 229-236
- Relaterad länk:
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http://www.ncbi.nlm....
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https://onlinelibrar...
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://urn.kb.se/re...
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http://kipublication...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- In the Nordic Society for Paediatric Haematology and Oncology paediatric study acute myeloid leukaemia (AML) 93, event-free survival was 50% and overall survival was 66%, indicating that many patients were cured following relapse. Factors influencing outcome in children with relapsed AML were investigated. The study included all 146 children in the Nordic countries diagnosed with AML between 1988 and 2003, who relapsed. Data on disease characteristics and relapse treatment were related to outcome. Sixty-six percentage achieved remission with survival after relapse (5 years) 34 +/- 4%. Of 122 patients who received re-induction therapy, 77% entered remission with 40 +/- 5% survival. Remission rates were similar for different re-induction regimens but fludarabine, cytarabine, granulocyte colony-stimulating factor-based therapy had low treatment-related mortality. Prognostic factors for survival were duration of first complete remission (CR1) and stem cell transplantation (SCT) in CR1. In early relapse (<1 year in CR1), survival was 21 +/- 5% compared with 48 +/- 6% in late relapse. For children receiving re-induction therapy, survival in early relapse was 29 +/- 6% and 51 +/- 6% in late. Patients treated in CR1 with SCT, autologous SCT or chemotherapy had a survival of 18 +/- 9, 5 +/- 5 and 41 +/- 5%, respectively. Survival was 62 +/- 6% in 64 children given SCT as part of their relapse therapy. A significant proportion of children with relapsed AML can be cured, even those with early relapse. Children who receive re-induction therapy, enter remission and proceed to SCT can achieve a cure rate of 60%.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Acute Disease
- Adolescent
- Antineoplastic Combined Chemotherapy Protocols
- therapeutic use
- Child
- Cytarabine
- therapeutic use
- Cytogenetics
- Disease-Free Survival
- Female
- Follow-Up Studies
- Granulocyte Colony-Stimulating Factor
- therapeutic use
- Humans
- Leukemia
- Myeloid
- drug therapy
- mortality
- surgery
- Male
- Recurrence
- Remission Induction
- Statistics
- Nonparametric
- Stem Cell Transplantation
- Survival Rate
- Sweden
- Treatment Outcome
- Vidarabine
- analogs & derivatives
- therapeutic use
- Acute Disease
- stem-cell transplantation
- acute myeloid leukaemia
- chemotherapy
- relapse
- children
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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