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A comparative analy...
A comparative analysis of B cell-mediated myelin oligodendrocyte glycoprotein-experimental autoimmune encephalomyelitis pathogenesis in B cell-deficient mice reveals an effect on demyelination.
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- Svensson, Lars (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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Abdul-Majid, Khairul-Bariah (author)
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Bauer, Jan (author)
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Lassmann, Hans (author)
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- Harris, Robert A (author)
- Karolinska Institutet
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- Holmdahl, Rikard (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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(creator_code:org_t)
- 2002
- 2002
- English.
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In: European Journal of Immunology. - 1521-4141 .- 0014-2980. ; 32:7, s. 1939-1946
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http://dx.doi.org/10...
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Abstract
Subject headings
Close
- We have investigated the role of B cells in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) using B cell-deficient mice muMT) and mice bearing the X-linked immunodeficiency (xid). The mice were immunized with MOG(1-125 )in complete Freund's adjuvant but without use of pertussis toxin. B cell-deficient muMT mice on different genetic backgrounds (C57BL/10 and DBA/1 strains) developed EAE, although with a reduced clinical severity. Histological analyses revealed decreased demyelination in the central nervous system while the influx of inflammatory cells was similar or only slightly reduced as compared to B cell-sufficient control mice. Xid mice on the DBA/1 background also developed disease with a reduced disease severity. The anti-MOG antibody response in the xid mice was decreased, while the T cell response to MOG was unaffected. We thus demonstrate that B cells are not critical for the development of MOG-induced EAE but contribute to the severity. The contribution of B cells to pathogenesis appears to be mainly through demyelination rather than through inflammation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Non-U.S. Gov't
- Support
- Rats
- Myelin-Associated Glycoprotein : adverse effects
- Myelin Sheath : metabolism
- Inbred DBA
- Mice
- Inbred C57BL
- Male
- Immunologic Deficiency Syndromes
- Female
- Encephalomyelitis
- Experimental Autoimmune : pathology
- T-Lymphocytes : immunology
- Experimental Autoimmune : chemically induced
- Demyelinating Diseases
- Comparative Study
- Central Nervous System : pathology
- B-Lymphocytes : immunology
- Animal
Publication and Content Type
- art (subject category)
- ref (subject category)
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