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In vitro procoagula...
In vitro procoagulant and anticoagulant properties of Naja naja naja venom
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- Sundell, I.B. (författare)
- Department of Haematology, University of Liverpool, Liverpool L69 3GA, United Kingdom, Puget Sound Blood Center, 921 Terry Avenue, Seattle, WA 98104, United States
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- Ranby, M. (författare)
- Linköpings universitet,Avdelningen för klinisk kemi
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- Zuzel, M. (författare)
- Department of Haematology, University of Liverpool, Liverpool L69 3GA, United Kingdom
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- Robinson, K.A. (författare)
- Amer. Cardiovasc. Research Institute, 3155 Northwoods Place, Norcross, GA 30071, United States
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- Theakston, R.D.G. (författare)
- Alistair Reid Venom Research Unit, Liverpool Sch. of Tropical Medicine, Liverpool L3 5QA, United Kingdom
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(creator_code:org_t)
- 2003
- 2003
- Engelska.
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Ingår i: Toxicon. - 0041-0101 .- 1879-3150. ; 42:3, s. 239-247
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Bites by the Indian cobra (Naja naja naja) are common in India and Sri Lanka because of its close association with humans. Cobra venoms are complex and contain several toxic components, including neurotoxins that cause post-synaptic neuromuscular blockade with respiratory paralysis and even death. Bites may also cause extensive local necrosis by mechanisms not fully elucidated. Although no significant coagulopathy has been reported, N.n. naja venom can form blood clots in vitro by activating prothrombin as demonstrated by thrombin-specific chromogenic substrate. Scanning electron microscopy demonstrates that the clots formed by venom lack the thin fibrin strands of normal blood clots formed by thromboplastin or glass contact. Rheometry shows that clots formed by venom have abnormally low elasticity over an extended period and then, as the platelets contract, a retarded and more feeble increase in elasticity. Purified N.n. naja venom PLA2 inhibits platelet aggregation in PRP and explains the decreased clot retraction and retarded and compromised elasticity build up. The present study shows that the PLA 2 and the prothrombin activator from N.n. naja venom have effects on haemostasis and blood clotting, although such effects are not observed systemically in envenomed humans. © 2003 Elsevier Ltd. All rights reserved.
Nyckelord
- Blood clotting
- Naja naja naja venom
- Platelets
- Rheometry
- NATURAL SCIENCES
- NATURVETENSKAP
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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