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Sökning: L773:0090 3493 OR L773:1530 0293 > (2010-2014) > Hypoproteinemia doe...

  • Brauer, Kirk IUniversity of Texas Medical Branch (författare)

Hypoproteinemia does not alter plasma volume expansion in response to a 0.9% saline bolus in awake sheep

  • Artikel/kapitelEngelska2010

Förlag, utgivningsår, omfång ...

  • Williams and Wilkins,2010
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-60253
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-60253URI
  • https://doi.org/10.1097/CCM.0b013e3181ef45e2DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:121290889URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objective: To test the hypothesis that hypoproteinemia reduces plasma volume expansion produced by a bolus of crystalloid solution given to awake sheep. Design: Prospective and observational. Setting: Laboratory. Subjects: Five female merino sheep (n = 5) weighing 37 +/- 3 kg were anesthetized. Interventions: Each animal was subjected to a 5-day test period: day 1: 50 mL/min 0.9% saline infusion over 20 mins. Days 2-4: daily plasmapheresis and replacement of the shed plasma with 6 L of 0.9% saline were performed in increments. Measurements and Main Results: Fractional plasma volume expansion after rapid infusion of saline on days 1 and 5 was calculated from changes in hemoglobin concentration. There was a significant reduction in total plasma protein concentration after plasmapheresis (p andlt; .05). Colloid osmotic pressures were also significantly lowered (p andlt; .05). A crystalloid infusion of 0.9% saline did not alter any of these values compared with baseline. The hemodynamic measurements did not show significant differences between the experiments. The plasma volume expansion reached approximately 20% at the end of infusion and stayed at 10-15% during the experiments. No difference was found in plasma volume expansion produced by a bolus of 50 mL/min of 0.9% in the hypoproteinemic state when compared with the euproteinemic state (p = .61). No difference in cumulative urinary output was found between the two states. Conclusions: In contrast to our hypothesis, severe acute hypoproteinemia does not reduce plasma volume expansion in response to 50 mL/min 0.9% saline infusion in nonspleenectomized sheep when compared with the resultant plasma volume expansion after a 50 mL/min of 0.9% infusion in the euproteinemic state.

Ämnesord och genrebeteckningar

  • anesthesia
  • hypoproteinemia
  • plasma volume expansion
  • crystalloids
  • fluid distribution
  • MEDICINE
  • MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Brauer, Lance PUniversity of Texas Medical Branch (författare)
  • Prough, Donald SUniversity of Texas Medical Branch (författare)
  • Rodhe, PeterKarolinska Institute (författare)
  • Hahn, Robert GKarolinska Institutet,Östergötlands Läns Landsting,Linköpings universitet,Anestesiologi med intensivvård,Hälsouniversitetet,Anestesi- och operationkliniken US(Swepub:liu)robha40 (författare)
  • Traber, Daniel LUniversity of Texas Medical Branch (författare)
  • Traber, Lilian DUniversity of Texas Medical Branch (författare)
  • Svensen, Christer HKarolinska Institutet (författare)
  • University of Texas Medical BranchKarolinska Institute (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:CRITICAL CARE MEDICINE: Williams and Wilkins38:10, s. 2011-20150090-34931530-0293

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