Hypoproteinemia does not alter plasma volume expansion in response to a 0.9% saline bolus in awake sheep

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Hypoproteinemia does not alter plasma volume expansion in response to a 0.9% saline bolus in awake sheep

Brauer, Kirk I (author): University of Texas Medical Branch

Brauer, Lance P (author): University of Texas Medical Branch

Prough, Donald S (author): University of Texas Medical Branch

Rodhe, Peter (author): Karolinska Institute

Hahn, Robert G (author): Karolinska Institutet,Östergötlands Läns Landsting,Linköpings universitet,Anestesiologi med intensivvård,Hälsouniversitetet,Anestesi- och operationkliniken US

Traber, Daniel L (author): University of Texas Medical Branch

Traber, Lilian D (author): University of Texas Medical Branch

Svensen, Christer H (author): Karolinska Institutet

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Williams and Wilkins, 2010
2010
English.
In: CRITICAL CARE MEDICINE. - : Williams and Wilkins. - 0090-3493 .- 1530-0293. ; 38:10, s. 2011-2015

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Objective: To test the hypothesis that hypoproteinemia reduces plasma volume expansion produced by a bolus of crystalloid solution given to awake sheep. Design: Prospective and observational. Setting: Laboratory. Subjects: Five female merino sheep (n = 5) weighing 37 +/- 3 kg were anesthetized. Interventions: Each animal was subjected to a 5-day test period: day 1: 50 mL/min 0.9% saline infusion over 20 mins. Days 2-4: daily plasmapheresis and replacement of the shed plasma with 6 L of 0.9% saline were performed in increments. Measurements and Main Results: Fractional plasma volume expansion after rapid infusion of saline on days 1 and 5 was calculated from changes in hemoglobin concentration. There was a significant reduction in total plasma protein concentration after plasmapheresis (p andlt; .05). Colloid osmotic pressures were also significantly lowered (p andlt; .05). A crystalloid infusion of 0.9% saline did not alter any of these values compared with baseline. The hemodynamic measurements did not show significant differences between the experiments. The plasma volume expansion reached approximately 20% at the end of infusion and stayed at 10-15% during the experiments. No difference was found in plasma volume expansion produced by a bolus of 50 mL/min of 0.9% in the hypoproteinemic state when compared with the euproteinemic state (p = .61). No difference in cumulative urinary output was found between the two states. Conclusions: In contrast to our hypothesis, severe acute hypoproteinemia does not reduce plasma volume expansion in response to 50 mL/min 0.9% saline infusion in nonspleenectomized sheep when compared with the resultant plasma volume expansion after a 50 mL/min of 0.9% infusion in the euproteinemic state.

Keyword

anesthesia
hypoproteinemia
plasma volume expansion
crystalloids
fluid distribution
MEDICINE
MEDICIN

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By the author/editor: Brauer, Kirk I; Brauer, Lance P; Prough, Donald S; Rodhe, Peter; Hahn, Robert G; Traber, Daniel L; show more...; Traber, Lilian D; Svensen, Christe ...; show less...

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By the university: Linköping University; Karolinska Institutet

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