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Early depletion of ...
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Berkestedt, IngridLund University,Lunds universitet,Kritiska infektioner,Forskargrupper vid Lunds universitet,Critical infections,Lund University Research Groups,Skåne University Hospital
(författare)
Early depletion of contact system in patients with sepsis : a prospective matched control observational study
- Artikel/kapitelEngelska2018
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LIBRIS-ID:oai:lup.lub.lu.se:0dccf2e2-92e5-4a68-b0ce-1bd366760b7e
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https://lup.lub.lu.se/record/0dccf2e2-92e5-4a68-b0ce-1bd366760b7eURI
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https://doi.org/10.1111/apm.12898DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:139643827URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Activation of the contact system generates bradykinin from high-molecular-weight kininogen and has been suggested to participate in the pathophysiology of sepsis. To test this, we prospectively measured bradykinin and high-molecular-weight kininogen levels in a cohort of sepsis patients requiring intensive care. From 29 patients meeting criteria for sepsis or septic shock according to Sepsis-3, blood was sampled within 24 h and on the fourth day following admittance to intensive care. Patients planned for neurosurgery served as matched controls. Sequential organ failure assessment score and 90-day mortality was registered. Bradykinin levels (median [interquartile range]) were lower in sepsis patients (79 [62–172] pg/ml) compared to controls (130 [86–255] pg/ml, p < 0.025) and did not correlate with mortality or severity of circulatory derangement. High-molecular-weight kininogen levels were lower in sepsis patients (1.6 [0.8–4.8] densitometry units) compared to controls (4.4 [2.9–7.7] densitometry units, p < 0.001), suggesting previous contact system activation. High-molecular-weight kininogen levels were lower in non-survivors than survivors (p = 0.003) and negatively correlated to severity of circulatory derangement. We conclude that a role for bradykinin in later stages of severe sepsis must be challenged. Low high-molecular-weight kininogen concentrations suggest that the decrease in bradykinin is due to substrate depletion.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Andersson, PiaLund University,Lunds universitet,Host parasite interactions,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mikr-pan
(författare)
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Herwald, HeikoLund University,Lunds universitet,Host parasite interactions,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medk-hhe
(författare)
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Valik, John KarlssonKarolinska Institutet,Karolinska Institute,Karolinska University Hospital
(författare)
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Sörensen, OlaLund University,Skåne University Hospital
(författare)
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Bodelsson, MikaelLund University,Lunds universitet,Kritiska infektioner,Forskargrupper vid Lunds universitet,Critical infections,Lund University Research Groups,Skåne University Hospital(Swepub:lu)anes-mbo
(författare)
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Kritiska infektionerForskargrupper vid Lunds universitet
(creator_code:org_t)
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Ingår i:APMIS: Wiley, s. 892-8980903-46411600-0463
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