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- Nilsson, BjörnLund University,Lunds universitet,Institutionen för laboratoriemedicin,Medicinska fakulteten,Department of Laboratory Medicine,Faculty of Medicine (author)
Threshold-free high-power methods for the ontological analysis of genome-wide gene expression studies
- Article/chapterEnglish2007
Publisher, publication year, extent ...
- Springer Science and Business Media LLC,2007
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:kth-37106
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-37106URI
- https://doi.org/10.1186/gb-2007-8-5-r74DOI
- https://lup.lub.lu.se/record/651068URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- QC 20110801
- Ontological analysis facilitates microarray data interpretation. We describe new ontological analysis methods which, unlike existing approaches, are threshold-free and statistically powerful. We perform extensive evaluations and introduce a new concept, detection spectra, to characterize methods. We show that different ontological analysis methods exhibit distinct detection spectra, and that it is critical to account for this diversity. Our results argue strongly against the continued use of existing methods, and provide directions towards an enhanced approach.
Subject headings and genre
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
- Biology
- Biologi
Added entries (persons, corporate bodies, meetings, titles ...)
- Håkansson, PetraKTH,Reglerteknik(Swepub:kth)- (author)
- Johansson, MikaelKTH,Reglerteknik(Swepub:kth)u13pw0wb (author)
- Nelander, Sven (author)
- Fioretos, ThoasLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kgen-tfi (author)
- Johnels, PetraLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)kgen-pha (author)
- Institutionen för laboratoriemedicinMedicinska fakulteten (creator_code:org_t)
Related titles
- In:Genome Biology: Springer Science and Business Media LLC8:5, s. R74-1474-760X1465-69061474-7596
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- About the subject
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- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
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- MEDICAL AND HEALTH SCIENCES
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- and Basic Medicine
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- Royal Institute of Technology
- Lund University
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