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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03036naa a2200421 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:139878091 | |
| 003 | SwePub | |
| 008 | 240701s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1398780912 URI |
| 024 | 7 | a https://doi.org/10.1152/physiolgenomics.00061.20182 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Blackwell, TA4 aut |
| 245 | 1 0 | a Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice |
| 264 | 1 | b American Physiological Society,c 2018 |
| 520 | a Cancer-cachexia (CC) is a wasting condition directly responsible for 20–40% of cancer-related deaths. The mechanisms controlling development of CC-induced muscle wasting are not fully elucidated. Most investigations focus on the postcachectic state and do not examine progression of the condition. We recently demonstrated mitochondrial degenerations precede muscle wasting in time course progression of CC. However, the extent of muscle perturbations before wasting in CC is unknown. Therefore, we performed global gene expression analysis in CC-induced muscle wasting to enhance understanding of intramuscular perturbations across the development of CC. Lewis lung carcinoma (LLC) was injected into the hind-flank of C57BL6/J mice at 8 wk of age with tumor allowed to develop for 1, 2, 3, or 4 wk and compared with PBS-injected control. Muscle wasting was evident at 4 wk LLC. RNA sequencing of gastrocnemius muscle samples showed widespread alterations in LLC compared with PBS animals with largest differences seen in 4 wk LLC, suggesting extensive transcriptomic alterations concurrent to muscle wasting. Commonly altered pathways included: mitochondrial dysfunction and protein ubiquitination, along with other less studied processes in this condition regulating transcription/translation and cytoskeletal structure. Current findings present novel evidence of transcriptomic shifts and altered cellular pathways in CC-induced muscle wasting. | |
| 700 | 1 | a Cervenka, I4 aut |
| 700 | 1 | a Khatri, B4 aut |
| 700 | 1 | a Brown, JL4 aut |
| 700 | 1 | a Rosa-Caldwell, ME4 aut |
| 700 | 1 | a Lee, DE4 aut |
| 700 | 1 | a Perry, RA4 aut |
| 700 | 1 | a Brown, LA4 aut |
| 700 | 1 | a Haynie, WS4 aut |
| 700 | 1 | a Wiggs, MP4 aut |
| 700 | 1 | a Bottje, WG4 aut |
| 700 | 1 | a Washington, TA4 aut |
| 700 | 1 | a Kong, BC4 aut |
| 700 | 1 | a Ruas, JLu Karolinska Institutet4 aut |
| 700 | 1 | a Greene, NP4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Physiological genomicsd : American Physiological Societyg 50:12, s. 1071-1082q 50:12<1071-1082x 1531-2267x 1094-8341 |
| 856 | 4 | u https://journals.physiology.org/doi/pdf/10.1152/physiolgenomics.00061.2018 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:139878091 |
| 856 | 4 8 | u https://doi.org/10.1152/physiolgenomics.00061.2018 |
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