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Islet Autoimmunity ...
Islet Autoimmunity and HLA Markers of Presymptomatic and Clinical Type 1 Diabetes : Joint Analyses of Prospective Cohort Studies in Finland, Germany, Sweden, and the U.S
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- Anand, Vibha (author)
- IBM Thomas J. Watson Research Center
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- Li, Ying (author)
- IBM Thomas J. Watson Research Center
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- Liu, Bin (author)
- IBM Thomas J. Watson Research Center
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- Ghalwash, Mohamed (author)
- Ain Shams University,IBM Thomas J. Watson Research Center
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- Koski, Eileen (author)
- IBM Thomas J. Watson Research Center
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- Ng, Kenney (author)
- IBM Thomas J. Watson Research Center
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- Dunne, Jessica L (author)
- Juvenile Diabetes Research Foundation
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- Jönsson, Josefine (author)
- Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups,Skåne University Hospital
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- Winkler, Christiane (author)
- Technical University of Munich,Helmholtz Zentrum München
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- Knip, Mikael (author)
- University of Helsinki,Tampere University Hospital,Helsinki University Central Hospital,Folkhälsan Research Center
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- Toppari, Jorma (author)
- Turku University Hospital,University of Turku
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- Ilonen, Jorma (author)
- University of Turku,Turku University Hospital
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- Killian, Michael B (author)
- Pacific Northwest Research Institute
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- Frohnert, Brigitte I (author)
- University of Colorado
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- Lundgren, Markus (author)
- Helmholtz Zentrum München
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- Ziegler, Anette-Gabriele (author)
- Technical University of Munich,Helmholtz Zentrum München
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- Hagopian, William (author)
- Pacific Northwest Research Institute
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- Veijola, Riitta (author)
- University of Oulu,Oulu University Hospital
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- Rewers, Marian (author)
- University of Colorado
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IBM Thomas J Watson Research Center Ain Shams University (creator_code:org_t)
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- 2021-06-23
- 2021
- English 8 s.
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In: Diabetes Care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 44, s. 2269-2276
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Abstract
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- OBJECTIVE: To combine prospective cohort studies, by including HLA harmonization, and estimate risk of islet autoimmunity and progression to clinical diabetes.RESEARCH DESIGN AND METHODS: For prospective cohorts in Finland, Germany, Sweden, and the U.S., 24,662 children at increased genetic risk for development of islet autoantibodies and type 1 diabetes have been followed. Following harmonization, the outcomes were analyzed in 16,709 infants-toddlers enrolled by age 2.5 years.RESULTS: In the infant-toddler cohort, 1,413 (8.5%) developed at least one autoantibody confirmed at two or more consecutive visits (seroconversion), 865 (5%) developed multiple autoantibodies, and 655 (4%) progressed to diabetes. The 15-year cumulative incidence of diabetes varied in children with one, two, or three autoantibodies at seroconversion: 45% (95% CI 40-52), 85% (78-90), and 92% (85-97), respectively. Among those with a single autoantibody, status 2 years after seroconversion predicted diabetes risk: 12% (10-25) if reverting to autoantibody negative, 30% (20-40) if retaining a single autoantibody, and 82% (80-95) if developing multiple autoantibodies. HLA-DR-DQ affected the risk of confirmed seroconversion and progression to diabetes in children with stable single-autoantibody status. Their 15-year diabetes incidence for higher- versus lower-risk genotypes was 40% (28-50) vs. 12% (5-38). The rate of progression to diabetes was inversely related to age at development of multiple autoantibodies, ranging from 20% per year to 6% per year in children developing multipositivity in ≤2 years or >7.4 years, respectively.CONCLUSIONS: The number of islet autoantibodies at seroconversion reliably predicts 15-year type 1 diabetes risk. In children retaining a single autoantibody, HLA-DR-DQ genotypes can further refine risk of progression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
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- By the author/editor
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Anand, Vibha
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Li, Ying
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Liu, Bin
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Ghalwash, Mohame ...
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Koski, Eileen
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Ng, Kenney
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show more...
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Dunne, Jessica L
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Jönsson, Josefin ...
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Winkler, Christi ...
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Knip, Mikael
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Toppari, Jorma
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Ilonen, Jorma
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Killian, Michael ...
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Frohnert, Brigit ...
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Lundgren, Markus
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Ziegler, Anette- ...
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Hagopian, Willia ...
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Veijola, Riitta
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Rewers, Marian
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes Care
- By the university
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Lund University