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FältnamnIndikatorerMetadata
00007140naa a2200709 4500
001oai:lup.lub.lu.se:d072e5a5-513c-49fb-b462-29521970c90c
003SwePub
008200315s2020 | |||||||||||000 ||eng|
009oai:DiVA.org:oru-88954
009oai:prod.swepub.kib.ki.se:232154116
009oai:gup.ub.gu.se/291708
0247 a https://lup.lub.lu.se/record/d072e5a5-513c-49fb-b462-29521970c90c2 URI
0247 a https://doi.org/10.1016/j.jcte.2020.1002182 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-889542 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:2321541162 URI
0247 a https://gup.ub.gu.se/publication/2917082 URI
040 a (SwePub)lud (SwePub)orud (SwePub)kid (SwePub)gu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Funkquist, Anders,d 1977-u Halmstad County Hospital,Dpt. of Medicine, Halland Central Hospital, Halmstad, Sweden4 aut0 (Swepub:oru)aft
2451 0a Low CSF/serum ratio of free T4 is associated with decreased quality of life in mild hypothyroidism – A pilot study : CSF/s-T4 associated with QoL in hypothyroidism
264 1a Netherlands :b Elsevier BV,c 2020
500 a Funding Agency:Sodra Sjukvardsregionen and Region Hallands forskningsfond 
520 a Background & Objective: Patients with mild hypothyroidism often are depressed and have impaired quality of life despite serum free-T4 and T3 within reference values. Therefore, we investigated whether their symptoms were dependent on the concentrations of free -T4 and T3 in the circulation and cerebrospinal fluid (CSF). Methods: Twenty-five newly diagnosed, untreated hypothyroid subjects and as many age- and sex-matched healthy controls were investigated. Blood and CSF sampling was performed in the morning after an overnight fast. Quality of life (QoL) was assessed by a Likert scale. In the hypothyroid subjects, the MADRS rating scale was also used to evaluate symptoms of depression. Furthermore, the results obtained by the questionnaires were related to serum and CSF levels of free- T4 and T3 as well as the ratios between them in CSF and in serum. Results: Self-reported health was considerably lower in hypothyroid subjects. MADRS was considerably higher than the normal range for healthy individuals. Low CSF/serum free-T4 ratio was correlated with an increased depressed state according to MADRS (p < 0.01), and in addition, CSF/serum free-T4 ratio correlated positively with the self-reported general health Likert scale (p < 0.05). Concentrations of TSH, or free-T3 in serum or CSF, were not associated with an increased depressed state or self-reported general health. Conclusions: Low CSF/serum ratio of free-T4 was correlated with impaired general health and mood, in contrast to serum measurements not showing any correlations. These findings might partly explain why some patients with hypothyroidism suffer from mental symptoms, despite adequate serum levels of free-T4. However, the findings need to be confirmed in further and larger studies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a MADRS
653 a Mild hypothyroidism
653 a Quality of life
653 a Subclinical hypothyroidism
653 a Thyroxine
653 a Triiodothyronine
653 a Endocrinology
653 a Thyroid hormone
653 a QUALITY OF LIFE
653 a Cognition
653 a Neuropsychiatry
653 a Neurology
7001 a Bengtsson, Andersu Karolinska Institute,Dpt. of Medicine, Halland Central Hospital, Halmstad, Sweden; Dpt. of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden,Halmstad County Hospital4 aut
7001 a Johansson, P. M.u Gothenburg University,Göteborgs universitet,Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Dpt. of Clinical Sciences Helsingborg, Lund University, Sweden; Dpt. of Internal Medicine at Institute of Medicine, Sahlgrenska Academy, University of Göteborg, Sweden,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xjperq
7001 a Svensson, Johanu Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xsjohc
7001 a Bjellerup, Peru Dpt. of Laboratory Medicine, Central Hospital Västmanland, Västerås, Sweden4 aut
7001 a Blennow, Kaju Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka
7001 a Wandt, Birgeru Örebro University,Dpt. of Research and Education, Örebro University Hospital, Örebro, Sweden; School of Health and Medical Sciences, Örebro University, Örebro, Sweden4 aut
7001 a Sjöberg, Stefanu Karolinska Institutet,Karolinska Institute,Halmstad County Hospital,Dpt. of Medicine, Halland Central Hospital, Halmstad, Sweden; Dpt. of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden4 aut
7102 a Halmstad County Hospitalb Dpt. of Medicine, Halland Central Hospital, Halmstad, Sweden4 org
7730 t Journal of Clinical and Translational Endocrinologyd Netherlands : Elsevier BVg 19q 19x 2214-6237
8564 u http://dx.doi.org/10.1016/j.jcte.2020.100218x freey FULLTEXT
8564 u https://doi.org/10.1016/j.jcte.2020.100218
8564 u https://doi.org/10.1016/j.jcte.2020.100218y Fulltext
8564 u https://oru.diva-portal.org/smash/get/diva2:1522298/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
8564 8u https://lup.lub.lu.se/record/d072e5a5-513c-49fb-b462-29521970c90c
8564 8u https://doi.org/10.1016/j.jcte.2020.100218
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-88954
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:232154116
8564 8u https://gup.ub.gu.se/publication/291708

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