WFRF:(Åhs Fredrik)
Sökning: WFRF:(Åhs Fredrik) > (2010-2014) > Increased neurokini...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04602naa a2200493 4500 | |
| 001 | oai:DiVA.org:uu-159946 | |
| 003 | SwePub | |
| 008 | 111012s2011 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:miun-38901 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1599462 URI |
| 024 | 7 | a https://doi.org/10.1016/j.eplepsyres.2011.08.0062 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-389012 URI |
| 040 | a (SwePub)uud (SwePub)miun | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Danfors, Torstenu Uppsala universitet,Neurologi,Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden; Section of Nuclear Medicine and PET, Department of Radiology, Oncology and Radiation Sciences, Uppsala University, Sweden4 aut0 (Swepub:uu)tordan |
| 245 | 1 0 | a Increased neurokinin-1 receptor availability in temporal lobe epilepsy :b A positron emission tomography study using [(11)C]GR205171 |
| 264 | 1 | b Elsevier BV,c 2011 |
| 338 | a print2 rdacarrier | |
| 520 | a PURPOSE: Activation of the neurokinin-1 (NK1) receptor by neuropeptide substance P (SP) induces and maintains epileptic activity in various experimental models of epilepsy. The primary objective of this study was to investigate whether neurobiological changes linked to NK1-SP receptor system are associated with hyperexcitability in patients with temporal lobe epilepsy (TLE). A secondary objective was to investigate the relationship between seizure frequency and NK1 receptor availability. METHODS: A positron emission tomography study was conducted with the selective NK1 receptor antagonist [(11)C]GR205171 in nine patients with TLE and 18 healthy control participants. Parametric PET images were generated using the Patlak graphical method, with cerebellum as reference region. Data analyses including group comparisons were performed using statistical parametric mapping. RESULTS: Patients with TLE showed increased NK1 receptor availability in both hemispheres with the most pronounced increase in anterior cingulate gyrus ipsilateral to seizure onset. A positive correlation between NK1 receptor availability and seizure frequency was observed in the medial temporal lobe and in the lentiform nucleus ipsilateral to the seizure onset. CONCLUSION: Our results suggest that there is an intrinsic network using the NK1-SP receptor system for synaptic transmission and epileptiform activity in TLE. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a Epilepsy | |
| 653 | a PET | |
| 653 | a NK1 | |
| 653 | a Substance P | |
| 653 | a TLE | |
| 653 | a Neurology | |
| 653 | a Neurologi | |
| 700 | 1 | a Åhs, Fredriku Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:miun)freahs |
| 700 | 1 | a Appel, Lieuweu Uppsala universitet,Enheten för nuklearmedicin och PET,Section of Nuclear Medicine and PET, Department of Radiology, Oncology and Radiation Sciences, Uppsala University, Sweden4 aut0 (Swepub:uu)lap02157 |
| 700 | 1 | a Linnman, Clasu Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden; P.A.I.N. group, McLean Hospital, Harvard Medical School, Boston, MA, USA4 aut0 (Swepub:uu)cllin103 |
| 700 | 1 | a Fredrikson, Matsu Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)matsfred |
| 700 | 1 | a Furmark, Tomasu Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)tomafurm |
| 700 | 1 | a Kumlien, Evau Uppsala universitet,Neurologi,Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)evakumli |
| 710 | 2 | a Uppsala universitetb Neurologi4 org |
| 773 | 0 | t Epilepsy Researchd : Elsevier BVg 97:1-2, s. 183-189q 97:1-2<183-189x 0920-1211x 1872-6844 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-159946 |
| 856 | 4 8 | u https://doi.org/10.1016/j.eplepsyres.2011.08.006 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-38901 |
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