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Search: WFRF:(Čuković Čavka Silvija) > (2019) > Natural Disease Cou...

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FältnamnIndikatorerMetadata
00010711naa a2200949 4500
001oai:DiVA.org:oru-69337
003SwePub
008181008s2019 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-693372 URI
0247 a https://doi.org/10.1093/ecco-jcc/jjy1542 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Burisch, Johanu Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark4 aut
2451 0a Natural Disease Course of Ulcerative Colitis During the First Five Years of Follow-up in a European Population-based Inception Cohort-An Epi-IBD Study
264 c 2018-10-05
264 1b Oxford University Press,c 2019
338 a print2 rdacarrier
500 a Funding Agencies:Kirsten og Freddy Johansens Fond  Nordsjaellands Hospital Forskningsrad 
520 a Background and Aims: Few population-based cohort studies have assessed the disease course of ulcerative colitis [UC] in the era of biological therapy and widespread use of immunomodulators. The aim of this study was to assess the 5-year outcome and disease course of patients with UC in the Epi-IBD cohort.Methods: In a prospective, population-based inception cohort of unselected patients with UC, patients were followed up from the time of their diagnosis, which included the collection of their clinical data, demographics, disease activity, medical therapy, and rates of surgery, cancers, and deaths. Associations between outcomes and multiple covariates were analysed by Cox regression analysis.Results: A total of 717 patients were included in the study. During follow-up, 43 [6%] patients underwent a colectomy and 163 [23%] patients were hospitalised. Of patients with limited colitis [distal to the left flexure], 90 [21%] progressed to extensive colitis. In addition, 92 [27%] patients with extensive colitis experienced a regression in disease extent, which was associated with a reduced risk of hospitalisation (hazard ratio [HR]: 0.5 95% CI: 0.3-0.8]. Overall, patients were treated similarly in both geographical regions; 80 [11%] patients needed biological therapy and 210 [29%] patients received immunomodulators. Treatment with immunomodulators was found to reduce the risk of hospitalisation [HR: 0.5 95% CI: 0.3-0.8].Conclusions: Although patients in this population-based cohort were treated more aggressively with immunomodulators and biological therapy than in cohorts from the previous two decades, their disease outcomes, including colectomy rates, were no different. However, treatment with immunomodulators was found to reduce the risk of hospitalisation.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
653 a Ulcerative colitis
653 a surgery
653 a hospitalisation
653 a prognosis
653 a treatment
653 a biologics
7001 a Katsanos, Konstantinos H.u Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece4 aut
7001 a Christodoulou, Dimitrios K.u Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece4 aut
7001 a Barros, Luisau Department of Gastroenterology, Centro Hospitalar de São João EPE, Porto, Portugal4 aut
7001 a Magro, Fernandou Department of Gastroenterology, Centro Hospitalar de São João EPE, Porto, Portugal; Department of Biomedicine, Institute of Pharmacology, Faculty of Medicine of Porto University, Porto, Portugal4 aut
7001 a Pedersen, Nataliau Gastroenterology Department, Slagelse Hospital, Slagelse, Denmark4 aut
7001 a Kjeldsen, Jensu Gastroenterology Department, Odense University Hospital, Odense, Denmark4 aut
7001 a Vegh, Zsuzsannau First Department of Medicine, Semmelweis University, Budapest, Hungary4 aut
7001 a Lakatos, Peter L.u First Department of Medicine, Semmelweis University, Budapest, Hungary; Division of Gastroenterology, McGill University Health Center, Montreal, QC, Canada4 aut
7001 a Eriksson, Carl,d 1981-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology4 aut0 (Swepub:oru)clen
7001 a Halfvarson, Jonas,d 1970-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology4 aut0 (Swepub:oru)jshn
7001 a Fumery, Mathurinu Gastroenterology Unit, Epimad Registry, CHU Amiens Sud, Amiens University Hospital, Amiens, France4 aut
7001 a Gower-Rousseau, Corinneu Public Health, Epidemiology and Economic Health, Registre Epimad, Lille University and Hospital, Lille, France; Lille Inflammation Research International Center LIRIC, Lille University, Lille, France4 aut
7001 a Brinar, Markou Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia4 aut
7001 a Čuković-Čavka, Silvijau Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia4 aut
7001 a Nikulina, Innau Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation4 aut
7001 a Belousova, Elenau Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation4 aut
7001 a Myers, Sallyu IBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK4 aut
7001 a Sebastian, Shajiu IBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK4 aut
7001 a Kiudelis, Gediminasu Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania4 aut
7001 a Kupcinskas, Limasu Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; Department of Gastroenterology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania4 aut
7001 a Schwartz, Doronu Department of Gastroenterology and Hepatology, Soroka Medical Center, Beer Sheva, Israel; Ben Gurion University of the Negev; Beer Sheva, Israel4 aut
7001 a Odes, Selwynu Department of Gastroenterology and Hepatology, Soroka Medical Center, Beer Sheva, Israel; Ben Gurion University of the Negev; Beer Sheva, Israel4 aut
7001 a Kaimakliotis, Ioannis P.u Nicosia Private Practice, Nicosia, Cyprus4 aut
7001 a Valpiani, Danielau U.O. Gastroenterologia ed Endoscopia digestiva, Hospital Morgagni Pierantoni, Forlì, Italy4 aut
7001 a D'Incà, Renatau Department of Surgical, Oncological and Gastroenterological Sciences, Azienda, University of Padua, Padova, Italy4 aut
7001 a Salupere, Riinau Division of Gastroenterology, Tartu University Hospital, University of Tartu, Tartu, Estonia4 aut
7001 a Zammit, Stefania Chetcutiu Division of Gastroenterology, Mater Dei Hospital, Msida, Malta4 aut
7001 a Ellul, Pierreu Division of Gastroenterology, Mater Dei Hospital, Msida, Malta4 aut
7001 a Duricova, Danau IBD Clinical and Research Centre, ISCARE, Prague, Czech Republic4 aut
7001 a Bortlik, Martinu IBD Clinical and Research Centre, ISCARE, Prague, Czech Republic; Institute of Pharmacology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic4 aut
7001 a Goldis, Adrianu Clinic of Gastroenterology, University of Medicine ‘Victor Babes’, Timisoara, Romania4 aut
7001 a Kievit, Hendrika Adriana Lindau Department of Medicine, Herning Central Hospital, Herning, Denmark4 aut
7001 a Toca, Alinau Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova4 aut
7001 a Turcan, Svetlanau Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova4 aut
7001 a Midjord, Jóngerðu Medical Department, National Hospital of the Faroe Islands, Torshavn, Faroe Islands4 aut
7001 a Nielsen, Kári Rubeku Medical Department, National Hospital of the Faroe Islands, Torshavn, Faroe Islands4 aut
7001 a Andersen, Karina Wintheru Medical Department, Regional Hospital of Viborg, Viborg, Denmark4 aut
7001 a Andersen, Vibekeu Medical Department, Regional Hospital of Viborg, Viborg, Denmark; Focused Research Unit for Molecular Diagnostic and Clinical Research [MOK], IRS-Center Sonderjylland, Hospital of Southern Jutland, Aabenraa, Denmark; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark4 aut
7001 a Misra, Raviu IBD Department, St Mark’s Hospital, London, UK4 aut
7001 a Arebi, Nailau IBD Department, St Mark’s Hospital, London, UK4 aut
7001 a Oksanen, Piau Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland; University of Tampere, Tampere, Finland4 aut
7001 a Collin, Pekkau Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland; University of Tampere, Tampere, Finland4 aut
7001 a de Castro, Luisau Department of Gastroenterology, Hospital Alvaro Cunqueiro, Instituto Investigación Sanitaria Galicia Sur, EOXI de Vigo, Vigo, Spain4 aut
7001 a Hernandez, Vicentu Department of Gastroenterology, Hospital Alvaro Cunqueiro, Instituto Investigación Sanitaria Galicia Sur, EOXI de Vigo, Vigo, Spain4 aut
7001 a Langholz, Ebbeu Department of Gastroenterology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Munkholm, Piau Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark4 aut
7001 a Epi-IBD, Group4 ctb
7102 a Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmarkb Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece4 org
7730 t Journal of Crohn's & Colitisd : Oxford University Pressg 13:2, s. 198-208q 13:2<198-208x 1873-9946x 1876-4479
8564 u http://repo.lib.semmelweis.hu//bitstream/123456789/7169/1/30398382.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-69337
8564 8u https://doi.org/10.1093/ecco-jcc/jjy154

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