WFRF:(Alving Kjell 1959 )
Sökning: WFRF:(Alving Kjell 1959 ) > Concurrence of elev...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03969naa a2200433 4500 | |
| 001 | oai:DiVA.org:uu-421290 | |
| 003 | SwePub | |
| 008 | 201007s2020 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4212902 URI |
| 024 | 7 | a https://doi.org/10.1002/ppul.245782 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kalm-Stephens, Pia,d 1959-u Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa4 aut0 (Swepub:uu)piaka760 |
| 245 | 1 0 | a Concurrence of elevated FeNO and airway hyperresponsiveness in nonasthmatic adolescents |
| 264 | c 2020-01-15 | |
| 264 | 1 | b Wiley,c 2020 |
| 338 | a print2 rdacarrier | |
| 520 | a OBJECTIVES: The aim of this study was to investigate airway responsiveness and eosinophil and neutrophil inflammatory markers in clinically confirmed nonasthmatic adolescents with elevated fractional exhaled nitric oxide (FeNO), a marker of type-2 inflammation in the airways.METHODOLOGY: A total of 959 subjects from a general population, aged 12 to 15 years, answered a standardised questionnaire and underwent FeNO measurements at a screening visit at school. Adolescents without asthma, who had elevated FeNO (FeNO100 > 15 ppb) (n = 19), and control subjects, with low FeNO (FeNO100 < 5 ppb) and without reported symptoms of asthma or allergy (n = 28), participated in a follow-up study where FeNO50 , airway responsiveness to methacholine (PD20 ), blood eosinophil counts, and serum neutrophil lipocalin (HNL) and myeloperoxidase (MPO) levels were measured. Questionnaire follow-ups were performed 4 and 16 years later.RESULTS: Airway responsiveness (PD20 : 6.94 [1.87, 11.39] vs 11.42 [6.33, 59.4] µmol; P < .05) and blood eosinophil counts (0.31 [0.20, 0.44] vs 0.13 [0.1, 0.22] 109 /L; P < .001) (geometric mean [95% CI]) were higher among cases than controls. A significant correlation between blood eosinophils and FeNO was found (rho = 0.41; P = .005). In contrast, serum HNL and MPO were lower in cases than controls (P < .05 both), and there was a negative correlation between HNL and FeNO (r = -0.31; P = .04). At both follow-ups, a higher proportion of subjects reported allergic symptoms compared with baseline (P = .02, P = .01).CONCLUSIONS: Elevated FeNO in nonasthmatic adolescents was associated with airway hyperresponsiveness, elevated blood eosinophil counts, and lower systemic activation of neutrophils. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
| 653 | a adolescents | |
| 653 | a breath test | |
| 653 | a eosinophilia | |
| 653 | a nitric oxide | |
| 653 | a respiratory hypersensitivity | |
| 653 | a Lungmedicin | |
| 653 | a Lung Medicine | |
| 700 | 1 | a Malinovschi, Andrei,d 1978-u Uppsala universitet,Klinisk fysiologi4 aut0 (Swepub:uu)anmal535 |
| 700 | 1 | a Janson, Christeru Uppsala universitet,Lung- allergi- och sömnforskning4 aut0 (Swepub:uu)chrisjn |
| 700 | 1 | a Venge, Peru Uppsala universitet,Klinisk kemi4 aut0 (Swepub:uu)pervenge |
| 700 | 1 | a Nordvall, Lennartu Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa4 aut0 (Swepub:uu)lennnord |
| 700 | 1 | a Alving, Kjell,d 1959-u Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa4 aut0 (Swepub:uu)kjeal631 |
| 710 | 2 | a Uppsala universitetb Pediatrisk inflammations- och metabolismforskning samt barnhälsa4 org |
| 773 | 0 | t Pediatric Pulmonologyd : Wileyg 55:3, s. 571-579q 55:3<571-579x 8755-6863x 1099-0496 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421290 |
| 856 | 4 8 | u https://doi.org/10.1002/ppul.24578 |
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