Sökning: WFRF:(Aly Markus) > Genetic dissection ...
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000 | 05205naa a2200565 4500 | |
001 | oai:lup.lub.lu.se:36833027-71b0-4660-aa61-c66be3b331f5 | |
003 | SwePub | |
008 | 231115s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/36833027-71b0-4660-aa61-c66be3b331f52 URI |
024 | 7 | a https://doi.org/10.1002/oby.238822 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Breitfeld, Janau Leipzig University4 aut |
245 | 1 0 | a Genetic dissection of serum vaspin highlights its causal role in lipid metabolism |
264 | 1 | c 2023 |
520 | a Objective: Vaspin (visceral adipose tissue derived serine protease inhibitor, SERPINA12) is associated with obesity-related metabolic traits, but its causative role is still elusive. The role of genetics in serum vaspin variability to establish its causal relationship with metabolically relevant traits was investigated. Methods: A meta-analysis of genome-wide association studies for serum vaspin from six independent cohorts (N = 7446) was conducted. Potential functional variants of vaspin were included in Mendelian randomization (MR) analyses to assess possible causal pathways between vaspin and homeostasis model assessment and lipid traits. To further validate the MR analyses, data from Genotype-Tissue Expression (GTEx) were analyzed, db/db mice were treated with vaspin, and serum lipids were measured. Results: A total of 468 genetic variants represented by five independent variants (rs7141073, rs1956709, rs4905216, rs61978267, rs73338689) within the vaspin locus were associated with serum vaspin (all p < 5×10−8, explained variance 16.8%). MR analyses revealed causal relationships between serum vaspin and triglycerides, low-density lipoprotein, and total cholesterol. Gene expression correlation analyses suggested that genes, highly correlated with vaspin expression in adipose tissue, are enriched in lipid metabolic processes. Finally, in vivo vaspin treatment reduced serum triglycerides in obese db/db mice. Conclusions: The data show that serum vaspin is strongly determined by genetic variants within vaspin, which further highlight vaspin's causal role in lipid metabolism. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Horn, Katrinu Leipzig University4 aut |
700 | 1 | a Le Duc, Dianau University Hospital Leipzig,Max Planck Institute for Evolutionary Anthropology4 aut |
700 | 1 | a Velluva, Akhilu Max Planck Institute for Evolutionary Anthropology,Leipzig University4 aut |
700 | 1 | a Marzi, Carolau German Center for Diabetes Research,Helmholtz Zentrum München4 aut |
700 | 1 | a Grallert, Haraldu Helmholtz Zentrum München,German Center for Diabetes Research4 aut |
700 | 1 | a Friedrich, Neleu German Centre for Cardiovascular Research,University Hospital Greifswald4 aut |
700 | 1 | a Pietzner, Maiku German Centre for Cardiovascular Research,Berlin Institute of Health (BIH)4 aut |
700 | 1 | a Völker, Uweu University Hospital Greifswald,German Centre for Cardiovascular Research4 aut |
700 | 1 | a Völzke, Henryu University Hospital Greifswald4 aut |
700 | 1 | a Ahlqvist, Emmau Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)infl-eah |
700 | 1 | a Aly, Dina Mansouru Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)di3053ma |
700 | 1 | a Tuomi, Tiinamaijau Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,University of Helsinki,Helsinki University Central Hospital4 aut0 (Swepub:lu)ti8736tu |
700 | 1 | a Baber, Ronnyu Leipzig University4 aut |
700 | 1 | a Kratzsch, Jürgenu Leipzig University4 aut |
700 | 1 | a Thiery, Joachimu University of Kiel4 aut |
700 | 1 | a Isermann, Berendu Leipzig University4 aut |
700 | 1 | a Loeffler, Markusu Leipzig University4 aut |
700 | 1 | a Klöting, Norau University Hospital Leipzig4 aut |
700 | 1 | a Blüher, Matthiasu University Hospital Leipzig4 aut |
700 | 1 | a Stumvoll, Michaelu German Center for Diabetes Research,Helmholtz Zentrum München,Leipzig University4 aut |
700 | 1 | a Heiker, John T.u University Hospital Leipzig4 aut |
700 | 1 | a Tönjes, Ankeu Leipzig University4 aut |
700 | 1 | a Scholz, Markusu Leipzig University4 aut |
700 | 1 | a Kovacs, Peteru Leipzig University4 aut |
710 | 2 | a Leipzig Universityb University Hospital Leipzig4 org |
773 | 0 | t Obesityg 31:11, s. 2862-2874q 31:11<2862-2874x 1930-7381 |
856 | 4 | u http://dx.doi.org/10.1002/oby.23882x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/36833027-71b0-4660-aa61-c66be3b331f5 |
856 | 4 8 | u https://doi.org/10.1002/oby.23882 |
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