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Sökning: WFRF:(Amoako Sakyi Daniel) > (2016) > Distribution of Fc ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004756naa a2200457 4500
001oai:DiVA.org:su-126898
003SwePub
008160216s2016 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1268982 URI
0247 a https://doi.org/10.1186/s12936-015-1082-82 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Cherif, Mariama4 aut
2451 0a Distribution of Fc gamma R gene polymorphisms among two sympatric populations in Mali :b differing allele frequencies, associations with malariometric indices and implications for genetic susceptibility to malaria
264 c 2016-01-19
264 1b Springer Science and Business Media LLC,c 2016
338 a print2 rdacarrier
520 a Background: Genetic polymorphisms in the complex gene cluster encoding human Fc-gamma receptors (Fc gamma Rs) may influence malaria susceptibility and pathogenesis. Studying genetic susceptibility to malaria is ideal among sympatric populations because the distribution of polymorphic genes among such populations can help in the identification malaria candidate genes. This study determined the distribution of three FcyRs single nucleotide polymorphisms (SNPs) (Fc gamma RIIB-rs1050519, Fc gamma RIIC-rs3933769 and Fc gamma RIIIA-rs396991) among sympatric Fulani and Dogon children with uncomplicated malaria. The association of these SNPs with clinical, malariometric and immunological indices was also tested. Methods: This study involved 242 Fulani and Dogon volunteers from Mali age under 15 years. All SNPs were genotyped with predesigned TaqMan (R) SNP Genotyping Assays. Genotypic and allelic distribution of SNPs was compared across ethnic groups using the Fisher exact test. Variations in clinical, malariometric and immunologic indices between groups were tested with Kruskal-Wallis H, Mann-Whitney U test and Fisher exact test where appropriate. Results: The study confirmed known malariometric and immunologic differences between sympatric Fulani and non-Fulani tribes. Parasite density was lower in the Fulani than the Dogon (p < 0.0001). The mutant allele of Fc gamma RIIC (rs3933769) was found more frequently in the Fulani than the Dogon (p < 0.0001) while that of Fc gamma RIIIA (rs396991) occurred less frequently in the Fulani than Dogon (p = 0.0043). The difference in the mutant allele frequency of Fc gamma RIIB (rs1050519) between the two ethnic groups was however not statistically significant (p = 0.064). The mutant allele of rs396991 was associated with high malaria-specific IgG1 and IgG3 in the entire study population and Dogon tribe, p = 0.023 and 0.015, respectively. Parasite burden was lower in carriers of the Fc gamma RIIC (rs3933769) mutant allele than non-carriers in the entire study population (p < 0.0001). Carriers of this allele harboured less than half the parasites found in non-carriers. Conclusion: Differences in the allelic frequencies of rs3933769 and rs396991 among Fulani and Dogon indirectly suggest that these SNPs may influence malaria susceptibility and pathogenesis in the study population. The high frequency of the Fc gamma RIIC (rs3933769) mutant allele in the Fulani and its subsequent association with low parasite burden in the entire study population is noteworthy.
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
7001 a Amoako-Sakyi, Daniel4 aut
7001 a Dolo, Amagana4 aut
7001 a Pearson, Jan-Olovu Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut
7001 a Gyan, Ben4 aut
7001 a Obiri-Yeboah, Dorcas4 aut
7001 a Nebie, Issa4 aut
7001 a Sirima, Sodiomon B.4 aut
7001 a Doumbo, Ogobara4 aut
7001 a Troye-Blomberg, Maritau Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)marita
7001 a Bakary, Maiga4 aut
7102 a Stockholms universitetb Institutionen för molekylär biovetenskap, Wenner-Grens institut4 org
7730 t Malaria Journald : Springer Science and Business Media LLCg 15q 15x 1475-2875
8564 u https://doi.org/10.1186/s12936-015-1082-8y Fulltext
8564 u https://malariajournal.biomedcentral.com/track/pdf/10.1186/s12936-015-1082-8
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-126898
8564 8u https://doi.org/10.1186/s12936-015-1082-8

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