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Prognostic nomogram...
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Lee, C.K.University of Sydney
(författare)
Prognostic nomogram to predict progression-free survival in patients with platinum-sensitive recurrent ovarian cancer
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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2011-09-13
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Cancer Research UK,2011
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-73593
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73593URI
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https://doi.org/10.1038/bjc.2011.364DOI
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BACKGROUND: Patients with platinum-sensitive recurrent ovarian cancer are a heterogeneous group, and it is not possible to accurately predict the progression-free survival (PFS) in these patients. We developed and validated a nomogram to help improve prediction of PFS in patients treated with platinum-based chemotherapy. METHODS: The nomogram was developed in a training cohort (n = 955) from the CALYPSO trial and validated in the AGO-OVAR 2.5 Study (n = 340). The proportional-hazards model (nomogram) was based on pre-treatment characteristics. RESULTS: The nomogram had a concordance index (C-index) of 0.645. Significant predictors were tumour size platinum-chemotherapy-free interval, CA-125, number of organ metastatic sites and white blood count. When the nomogram was applied without CA-125 (CA-125 was not available in validation cohort), the C-indices were 0.624 (training) and 0.594 (validation). When classification was based only on the platinum-chemotherapy-free interval, the indices were 0.571 (training) and 0.560 (validation). The calibration plot in the validation cohort based on four predictors (without CA-125) suggested good agreement between actual and nomogram-predicted 12-month PFS probabilities. CONCLUSION: This nomogram, using five pre-treatment characteristics, improves prediction of PFS in patients with platinum-sensitive ovarian cancer having platinum-based chemotherapy. It will be useful for the design and stratification of patients in clinical trials and also for counselling patients.
Ämnesord och genrebeteckningar
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nomogram; recurrent ovarian cancer; prognosis; platinum sensitivity; progression-free survival
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Simes, R.J.University of Sydney
(författare)
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Brown, C.University of Sydney
(författare)
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Lord, S.University of Sydney
(författare)
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Wagner, U.University Hospital Giessen and Marburg
(författare)
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Plante, M.CHUQ Hotel Dieu Quebec
(författare)
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Vergote, I.University Hospital Leuven
(författare)
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Pisano, C.National Cancer Institute, Naples
(författare)
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Parma, G.European Institute for Oncology
(författare)
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Burges, A.Klinikum University of Munic
(författare)
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Bourgeois, H.Centre Jean Bernard SARL SORECOH
(författare)
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Hogberg, T.Östergötlands Läns Landsting,Onkologiska kliniken US
(författare)
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Bentley, J.Dalhousie University, Halifax, NS B3H 1V7, Canada
(författare)
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Angleitner-Boubenizek, L.BHS Linz, A-4020 Linz, Austria
(författare)
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Ferrero, A.Mauriziano Hospital, Academic Div Gynecol Oncol, Turin, Italy
(författare)
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Richter, B.University of Dresden, Department Gynecol and Obstet, Dresden, Germany
(författare)
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Hirte, H.Juravinski Cancer Centre Hamilton Health Science, Hamilton, ON, Canada
(författare)
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Gebski, V.University of Sydney, NHMRC Clin Trials Centre, Camperdown, NSW 1450, Australia
(författare)
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Pfisterer, J.Staedt Klinikum Solingen, Department Gynecol, D-42653 Solingen, Germany
(författare)
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Pujade-Lauraine, E.University of Paris 05, Hop University of Paris Centre, AP HP, F-75004 Paris, France
(författare)
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Friedlander, M.Prince Wales Hospital, Institute Oncol, Sydney, NSW 2031, Australia
(författare)
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University of SydneyUniversity Hospital Giessen and Marburg
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British Journal of Cancer: Cancer Research UK105:8, s. 1144-11500007-09201532-1827
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Till lärosätets databas
- Av författaren/redakt...
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Lee, C.K.
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Simes, R.J.
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Brown, C.
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Lord, S.
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Wagner, U.
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Plante, M.
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visa fler...
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Vergote, I.
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Pisano, C.
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Parma, G.
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Burges, A.
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Bourgeois, H.
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Hogberg, T.
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Bentley, J.
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Angleitner-Boube ...
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Ferrero, A.
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Richter, B.
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Hirte, H.
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Gebski, V.
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Pfisterer, J.
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Pujade-Lauraine, ...
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Friedlander, M.
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