Novel Biomarkers of Habitual Alcohol Intake and Associations With Risk of Pancreatic and Liver Cancers and Liver Disease Mortality

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Novel Biomarkers of Habitual Alcohol Intake and Associations With Risk of Pancreatic and Liver Cancers and Liver Disease Mortality

Loftfield, Erikka (författare): Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States

Stepien, Magdalena (författare): Nutritional Epidemiology Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization

Viallon, Vivian (författare): Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization

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Trijsburg, Laura (författare): Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization

Rothwell, Joseph A. (författare): Nutritional Epidemiology Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France; Gustave Roussy, Villejuif, France; Biomarkers Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization

Robinot, Nivonirina (författare): Centre for Epidemiology and Population Health (U1018), Generations and Health team, UVSQ, INSERM, Faculté de Médecine ,Université Paris-Saclay, Villejuif, France

Biessy, Carine (författare): Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization

Bergdahl, Ingvar (författare): Umeå University,Umeå universitet,Enheten för biobanksforskning

Bodén, Stina (författare): Umeå University,Umeå universitet,Onkologi

Schulze, Matthias B. (författare): Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany

Bergman, Manuela (författare): Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany

Weiderpass, Elisabete (författare): International Agency for Research on Cancer, World Health Organization

Schmidt, Julie A. (författare): Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

Zamora-Ros, Raul (författare): Unit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain,Catalan Institute of Oncology-Girona

Nøst, Therese H. (författare): Department of Community Medicine, UiT- The Arctic University of Norway, Tromsø, Norway

Sandanger, Torkjel M. (författare): Department of Community Medicine, UiT- The Arctic University of Norway, Tromsø, Norway

Sonestedt, Emily (författare): Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups

Ohlsson, Bodil (författare): Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups

Katzke, Verena (författare): Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Kaaks, Rudolf (författare): Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Ricceri, Fulvio (författare): Department of Clinical and Biological Sciences, University of Turin, Italy; Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco, TO, Italy

Tjønneland, Anne (författare): Danish Cancer Society Research Center; University of Copenhagen, Department of Public Health

Dahm, Christina C. (författare): Department of Public Health, Aarhus University, Denmark

Sánchez, Maria-Jose (författare): Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain,Andalusian School Of Public Health (EASP)

Trichopoulou, Antonia (författare): Hellenic Health Foundation, Athens, Greece

Tumino, Rosario (författare): Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy

Chirlaque, María-Dolores (författare): Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain

Masala, Giovanna (författare): Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, Italy

Ardanaz, Eva (författare): Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; CIBER Epidemiology and Public Health CIBERESP, Madrid, Spain,Hospital of Navarra, Pamplona

Vermeulen, Roel (författare): Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht, Netherlands

Brennan, Paul (författare): Genetic Epidemiology Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization

Albanes, Demetrius (författare): Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States

Weinstein, Stephanie J. (författare): Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States

Scalbert, Augustin (författare): Centre for Epidemiology and Population Health (U1018), Generations and Health team, UVSQ, INSERM, Faculté de Médecine ,Université Paris-Saclay, Villejuif, France

Freedman, Neal D. (författare): Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States

Gunter, Marc J. (författare): Nutritional Epidemiology Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization

Jenab, Mazda (författare): Nutritional Epidemiology Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization

Sinha, Rashmi (författare): Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States

Keski-Rahkonen, Pekka (författare): Centre for Epidemiology and Population Health (U1018), Generations and Health team, UVSQ, INSERM, Faculté de Médecine ,Université Paris-Saclay, Villejuif, France

Ferrari, Pietro (författare): Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France,International Agency for Research on Cancer, World Health Organization

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2021-05-19
2021
Engelska.
Ingår i: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 113:11, s. 1542-1550

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Tidskriftsartikel (refereegranskat)

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BACKGROUND: Alcohol is an established risk factor for several cancers, but modest alcohol-cancer associations may be missed because of measurement error in self-reported assessments. Biomarkers of habitual alcohol intake may provide novel insight into the relationship between alcohol and cancer risk.METHODS: Untargeted metabolomics was used to identify metabolites correlated with self-reported habitual alcohol intake in a discovery dataset from the European Prospective Investigation into Cancer and Nutrition (EPIC; n = 454). Statistically significant correlations were tested in independent datasets of controls from case-control studies nested within EPIC (n = 280) and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC; n = 438) study. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations of alcohol-associated metabolites and self-reported alcohol intake with risk of pancreatic cancer, hepatocellular carcinoma (HCC), liver cancer, and liver disease mortality in the contributing studies.RESULTS: Two metabolites displayed a dose-response association with self-reported alcohol intake: 2-hydroxy-3-methylbutyric acid and an unidentified compound. A 1-SD (log2) increase in levels of 2-hydroxy-3-methylbutyric acid was associated with risk of HCC (OR = 2.54, 95% CI = 1.51 to 4.27) and pancreatic cancer (OR = 1.43, 95% CI = 1.03 to 1.99) in EPIC and liver cancer (OR = 2.00, 95% CI = 1.44 to 2.77) and liver disease mortality (OR = 2.16, 95% CI = 1.63 to 2.86) in ATBC. Conversely, a 1-SD (log2) increase in questionnaire-derived alcohol intake was not associated with HCC or pancreatic cancer in EPIC or liver cancer in ATBC but was associated with liver disease mortality (OR = 2.19, 95% CI = 1.60 to 2.98) in ATBC.CONCLUSIONS: 2-hydroxy-3-methylbutyric acid is a candidate biomarker of habitual alcohol intake that may advance the study of alcohol and cancer risk in population-based studies.

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Av författaren/redakt...: Loftfield, Erikk ...; Stepien, Magdale ...; Viallon, Vivian; Trijsburg, Laura; Rothwell, Joseph ...; Robinot, Nivonir ...; visa fler...; Biessy, Carine; Bergdahl, Ingvar; Bodén, Stina; Schulze, Matthia ...; Bergman, Manuela; Weiderpass, Elis ...; Schmidt, Julie A ...; Zamora-Ros, Raul; Nøst, Therese H.; Sandanger, Torkj ...; Sonestedt, Emily; Ohlsson, Bodil; Katzke, Verena; Kaaks, Rudolf; Ricceri, Fulvio; Tjønneland, Anne; Dahm, Christina ...; Sánchez, Maria-J ...; Trichopoulou, An ...; Tumino, Rosario; Chirlaque, María ...; Masala, Giovanna; Ardanaz, Eva; Vermeulen, Roel; Brennan, Paul; Albanes, Demetri ...; Weinstein, Steph ...; Scalbert, August ...; Freedman, Neal D ...; Gunter, Marc J.; Jenab, Mazda; Sinha, Rashmi; Keski-Rahkonen, ...; Ferrari, Pietro; visa färre...

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Av lärosätet: Umeå universitet; Lunds universitet

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Novel Biomarkers of Habitual Alcohol Intake and Associations With Risk of Pancreatic and Liver Cancers and Liver Disease Mortality

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