WFRF:(Betten Åsa 1967)
Sökning: WFRF:(Betten Åsa 1967) > A proinflammatory p...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04495naa a2200589 4500 | |
| 001 | oai:gup.ub.gu.se/48867 | |
| 003 | SwePub | |
| 008 | 240528s2001 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/488672 URI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Betten, Åsa,d 1967u Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology4 aut0 (Swepub:gu)xbetas |
| 245 | 1 0 | a A proinflammatory peptide from Helicobacter pylori activates monocytes to induce lymphocyte dysfunction and apoptosis |
| 264 | 1 | c 2001 |
| 520 | a Infection with Helicobacter pylori causes chronic gastritis, which is characterized by a dense mucosal infiltration by inflammatory cells such as monocytes/macrophages. H. pylori-induced inflammation is a risk factor for the development of gastric adenocarcinoma, but the mechanisms involved in H. pylori-associated carcinogenesis are poorly understood. A cecropin-like H. pylori peptide, Hp(2-20), was found to be a monocyte chemoattractant and activated the monocyte NADPH-oxidase to produce oxygen radicals. The receptors mediating monocyte activation were identified as FPRL1 and the monocyte-specific orphan receptor FPRL2. Hp(2-20)-activated monocytes inhibited lymphocytes with antitumor properties, such as CD56+ natural killer (NK) cells and CD3epsilon+ T cells. The changes observed in NK cells and T cells--a reduced antitumor cytotoxicity, downregulation of CD3zeta expression, and apoptosis--were mediated by Hp(2-20)-induced oxygen radicals. Histamine, a gastric mucosal constituent, rescued NK cells and T cells from inhibition and apoptosis by suppressing Hp(2-20)-induced oxygen radical formation. We conclude that H. pylori expression of this monocyte-activating peptide contributes to its ability to attract and activate monocytes and reduces the function and viability of antineoplastic lymphocytes. These novel mechanisms may be subject to local, histaminergic regulation in the gastric mucosa. | |
| 653 | a Adenocarcinoma/etiology | |
| 653 | a Amino Acid Sequence | |
| 653 | a Apoptosis | |
| 653 | a Bacterial Proteins/chemistry/*immunology/pharmacology | |
| 653 | a Chemotaxis | |
| 653 | a Leukocyte | |
| 653 | a Gastritis/etiology | |
| 653 | a Helicobacter Infections/etiology | |
| 653 | a Helicobacter pylori/*immunology/*pathogenicity | |
| 653 | a Humans | |
| 653 | a Inflammation Mediators/chemistry/immunology/pharmacology | |
| 653 | a Lymphocytes/cytology/immunology | |
| 653 | a Molecular Sequence Data | |
| 653 | a Monocytes/*immunology | |
| 653 | a NADPH Oxidase/metabolism | |
| 653 | a Peptides/chemistry/*immunology/pharmacology | |
| 653 | a Receptors | |
| 653 | a Formyl Peptide | |
| 653 | a Receptors | |
| 653 | a Immunologic/immunology | |
| 653 | a *Receptors | |
| 653 | a Lipoxin | |
| 653 | a Receptors | |
| 653 | a Peptide/immunology | |
| 653 | a Stomach Neoplasms/etiology | |
| 700 | 1 | a Bylund, Johan,d 1975u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xbyljo |
| 700 | 1 | a Christophe, T.4 aut |
| 700 | 1 | a Boulay, F.4 aut |
| 700 | 1 | a Romero, Ana,d 1975u Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology4 aut0 (Swepub:gu)xroman |
| 700 | 1 | a Hellstrand, Kristoffer,d 1956u Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi,Institute of Laboratory Medicine, Dept of Clinical Virology4 aut0 (Swepub:gu)xhellk |
| 700 | 1 | a Dahlgren, Claes,d 1949u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research4 aut0 (Swepub:gu)xdahcl |
| 710 | 2 | a Göteborgs universitetb Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi4 org |
| 773 | 0 | t J Clin Investg 108:8, s. 1221-8q 108:8<1221-8 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/48867 |
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