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First infant formul...
First infant formula type and risk of islet autoimmunity in the environmental determinants of diabetes in the young (TEDDY) study
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- Hummel, Sandra (författare)
- Technical University of Munich
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- Beyerlein, Andreas (författare)
- Technical University of Munich
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- Tamura, Roy N. (författare)
- University of South Florida
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- Uusitalo, Ulla (författare)
- University of South Florida
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- Andŕen Aronsson, Carin (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Yang, Jimin (författare)
- University of South Florida
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- Riikonen, Anne (författare)
- University of Tampere
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- Lernmark, Ake (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Rewers, Marian J. (författare)
- University of Colorado
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- Hagopian, William A. (författare)
- Pacific Northwest Research Institute
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- She, Jin-Xiong (författare)
- Medical College of Georgia
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- Simell, Olli G. (författare)
- Turku University Hospital
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- Toppari, Jorma (författare)
- Turku University Hospital
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- Ziegler, Anette-G (författare)
- Technical University of Munich
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Akolkar, Beena (författare)
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- Krischer, Jeffrey P. (författare)
- University of South Florida
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- Virtanen, Suvi M (författare)
- University of Tampere
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Norris, Jill M (författare)
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(creator_code:org_t)
- 2017-01-17
- 2017
- Engelska 7 s.
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Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 40:3, s. 398-404
- Relaterad länk:
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http://dx.doi.org/10...
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https://care.diabete...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- OBJECTIVE Studies on the introduction of infant formulas and its effect on the risk of islet autoimmunity and type 1 diabetes (T1D) have yielded inconsistent results. We investigated whether the introduction of formula based on hydrolyzed cow'smilk as the first formula is associated with reduced islet autoimmunity risk in a large prospective cohort. RESEARCH DESIGN AND METHODS The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively monitors 8,676 children at increased genetic risk for T1D. Autoantibodies to insulin, GAD65, and IA2 were measured regularly to define islet autoimmunity. Information on formula feeding was collected by questionnaires at 3 months of age. RESULTS In survival analyses, after adjustment for family history with T1D, HLA genotype, sex, country, delivery mode, breast-feeding 3 months, and seasonality of birth, we observed no significant association with islet autoimmunity in infants who received extensively hydrolyzed compared with nonhydrolyzed cow'smilk-based formula as the first formula during the first 3 months (adjusted hazard ratio 1.38 [95% CI 0.95; 2.01]), and a significantly increased risk for extensively hydrolyzed formula introduced during the first 7 days (adjusted hazard ratio 1.57 [1.04; 2.38]). Using a partially hydrolyzed or other formula as the first formula, or no formula, was not associated with islet autoimmunity risk. CONCLUSIONS These results add to the existing evidence that islet autoimmunity risk is not reduced, and may be increased, by using hydrolyzed compared with nonhydrolyzed cow's milk-based infant formula as the first formula in infants at increased genetic risk for T1D .
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Hummel, Sandra
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Beyerlein, Andre ...
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Tamura, Roy N.
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Uusitalo, Ulla
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Andŕen Aronsson, ...
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Yang, Jimin
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visa fler...
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Riikonen, Anne
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Lernmark, Ake
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Rewers, Marian J ...
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Hagopian, Willia ...
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She, Jin-Xiong
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Simell, Olli G.
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Toppari, Jorma
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Ziegler, Anette- ...
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Akolkar, Beena
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Krischer, Jeffre ...
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Virtanen, Suvi M
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Norris, Jill M
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visa färre...
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MEDICIN OCH HÄLS ...
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Diabetes Care
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Lunds universitet