Sökning: WFRF:(Bhatt Vijaya) > (2020) > Impact of cytogenet...
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001 | oai:DiVA.org:uu-412335 | |
003 | SwePub | |
008 | 200608s2020 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:143636768 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4123352 URI |
024 | 7 | a https://doi.org/10.3324/haematol.2019.2207562 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1436367682 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lazaryan, Aleksandru H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA.4 aut |
245 | 1 0 | a Impact of cytogenetic abnormalities on outcomes of adult Philadelphia-negative acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation :b a study by the Acute Leukemia Working Committee of the Center for International Blood and Marrow Transplant Research |
264 | c 2019-09-26 | |
264 | 1 | b Ferrata Storti Foundation (Haematologica),c 2020 |
338 | a electronic2 rdacarrier | |
520 | a Cytogenetic risk stratification at diagnosis has long been one of the most useful tools to assess prognosis in acute lymphoblastic leukemia (ALL). To examine the prognostic impact of cytogenetic abnormalities on outcomes after allogeneic hematopoietic cell transplantation, we studied 1731 adults with Philadelphia-negative ALL in complete remission who underwent myeloablative or reduced intensity/non-myeloablative conditioning transplant from unrelated or matched sibling donors reported to the Center for International Blood and Marrow Transplant Research. A total of 632 patients had abnormal conventional metaphase cytogenetics. The leukemia-free survival and overall survival rates at 5 years after transplantation in patients with abnormal cytogenetics were 40% and 42%, respectively, which were similar to those in patients with a normal karyotype. Of the previously established cytogenetic risk classifications, modified Medical Research Council-Eastern Cooperative Oncology Group score was the only independent prognosticator of leukemia-free survival (P=0.03). In the multivariable analysis, monosomy 7 predicted post-transplant relapse [hazard ratio (HR)=2.11; 95% confidence interval (95% CI): 1.04-4.27] and treatment failure (HR=1.97; 95% CI: 1.20-3.24). Complex karyotype was prognostic for relapse (HR=1.69; 95% CI: 1.06-2.69), whereas t(8;14) predicted treatment failure (HR=2.85; 95% CI: 1.35-6.02) and overall mortality (HR=3.03; 95% CI: 1.44-6.41). This large study suggested a novel transplant-specific cytogenetic scheme with adverse [monosomy 7, complex karyotype, del(7q), t(8;14), t(11;19), del(7q), tetraploidy/near triploidy], intermediate (normal karyotype and all other abnormalities), and favorable (high hyperdiploidy) risks to prognosticate leukemia-free survival (P=0.02). Although some previously established high-risk Philadelphia-negative cytogenetic abnormalities in ALL can be overcome by transplantation, monosomy 7, complex karyotype, and t(8;14) continue to pose significant risks and yield inferior outcomes. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
700 | 1 | a Dolan, Michelleu Univ Minnesota, Med Ctr, Minneapolis, MN 55455 USA.4 aut |
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700 | 1 | a Marks, David, Iu Univ Hosp Bristol NHS Trust, Adult Bone Marrow Transplant, Bristol, Avon, England.4 aut |
700 | 1 | a Bejanyan, Nelliu H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Tampa, FL USA.4 aut |
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700 | 1 | a Waller, Edmund K.u Emory Univ, Winship Canc Inst, Dept Hematol & Med Oncol, Atlanta, GA 30322 USA.4 aut |
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700 | 1 | a Kebriaei, Partowu Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Div Canc Med, Houston, TX 77030 USA.4 aut |
700 | 1 | a Inamoto, Yoshihirou Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan.4 aut |
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700 | 1 | a Bacher, Ulrikeu Bern Univ Hosp, Inselspital, Dept Hematol, Bern, Switzerland.4 aut |
700 | 1 | a Hildebrandt, Gerhard C.u Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.4 aut |
700 | 1 | a Stiff, Patrick J.u Loyola Univ Med Ctr, Maywood, IL 60153 USA.4 aut |
700 | 1 | a McGuirk, Josephu Univ Kansas, Med Ctr, Westwood, KS USA.4 aut |
700 | 1 | a Aldoss, Ibrahimu City Hope Natl Med Ctr, Comprehens Canc Ctr, Duarte, CA USA.4 aut |
700 | 1 | a Beitinjaneh, Amer M.u Univ Miami, Miami, FL USA.4 aut |
700 | 1 | a Muffly, Loriu Stanford Univ, Div Blood & Marrow Transplantat, Stanford, CA 94305 USA.4 aut |
700 | 1 | a Vij, Raviu Washington Univ, Sch Med, Div Hematol & Oncol, St Louis, MO USA.4 aut |
700 | 1 | a Olsson, Richardu Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden4 aut0 (Swepub:uu)riols677 |
700 | 1 | a Byrne, Michaelu Vanderbilt Univ, Med Ctr, Nashville, TN USA.4 aut |
700 | 1 | a Schultz, Kirk R.u Univ British Columbia, British Columbias Childrens Hosp, Dept Pediat Hematol Oncol & Bone Marrow Transplan, Vancouver, BC, Canada.4 aut |
700 | 1 | a Aljurf, Mahmoudu King Faisal Specialist Hosp & Res Ctr, Oncol Ctr, Riyadh, Saudi Arabia.4 aut |
700 | 1 | a Seftel, Matthewu CancerCare Manitoba, Dept Med Oncol & Hematol, Winnipeg, MB, Canada.4 aut |
700 | 1 | a Savoie, Mary Lynnu Tom Baker Canc Clin, Calgary, AB, Canada.4 aut |
700 | 1 | a Savani, Bipin N.u Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.4 aut |
700 | 1 | a Verdonck, Leo F.u Isala Clin, Dept Hematol Oncol, Zwolle, Netherlands.4 aut |
700 | 1 | a Cairo, Mitchell S.u New York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, Valhalla, NY 10595 USA.4 aut |
700 | 1 | a Hossain, Nasheedu Loyola Univ Chicago, Stritch Sch Med, Maywood, IL USA.4 aut |
700 | 1 | a Bhatt, Vijaya Raju Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA.4 aut |
700 | 1 | a Frangoul, Haydar A.u Childrens Hosp TriStar Centennial, Nashville, TN USA.;Sarah Cannon Res Inst, Nashville, TN USA.4 aut |
700 | 1 | a Abdel-Azim, Hishamu Univ Southern Calif, Keck Sch Med, Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA 90007 USA.4 aut |
700 | 1 | a Al Malki, Monzru City Hope Natl Med Ctr, Comprehens Canc Ctr, Duarte, CA USA.4 aut |
700 | 1 | a Munker, Reinholdu Louisiana State Univ Hlth Shreveport, Dept Internal Med, Sect Hematol Oncol, Shreveport, LA USA.4 aut |
700 | 1 | a Rizzieri, Davidu Duke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA.4 aut |
700 | 1 | a Khera, Nanditau Mayo Clin, Dept Hematol Oncol, Phoenix, AZ USA.4 aut |
700 | 1 | a Nakamura, Ryotarou City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Duarte, CA USA.4 aut |
700 | 1 | a Ringden, Olleu Karolinska Institutet4 aut |
700 | 1 | a van der Poel, Marjoleinu Acad Ziekenhuis Maastricht, Maastricht, Netherlands.4 aut |
700 | 1 | a Murthy, Hemant S.u Mayo Clin Florida, Jacksonville, FL USA.4 aut |
700 | 1 | a Liu, Hongtaou Univ Chicago Med, Chicago, IL USA.4 aut |
700 | 1 | a Mori, Shahramu Florida Hosp Med Grp, Blood & Marrow Transplant Ctr, Orlando, FL USA.4 aut |
700 | 1 | a De Oliveira, Satirou UCLA, Med Ctr, Los Angeles, CA 90024 USA.4 aut |
700 | 1 | a Bolanos-Meade, Javieru Sidney Kimmel Comprehens Canc Ctr Johns Hopkins B, Baltimore, MD USA.4 aut |
700 | 1 | a Elsawy, Mahmoudu Dalhousie Univ, QE II Hlth Sci Ctr, Halifax, NS, Canada.4 aut |
700 | 1 | a Barba, Pereu Hosp Valle De Hebron, Barcelona, Spain.4 aut |
700 | 1 | a Nathan, Sunitau Rush Univ, Med Ctr, Chicago, IL 60612 USA.4 aut |
700 | 1 | a George, Bijuu Christian Med Coll & Hosp, Vellore, Tamil Nadu, India.4 aut |
700 | 1 | a Pawarode, Attapholu Univ Michigan, Dept Internal Med, Div Hematol Oncol, Med Sch,Blood & Marrow Transplantat Program, Ann Arbor, MI USA.4 aut |
700 | 1 | a Grunwald, Michaelu Atrium Hlth, Levine Canc Inst, Dept Hematol Oncol & Blood Disorders, Charlotte, NC USA.4 aut |
700 | 1 | a Agrawal, Vaibhavu Indiana Univ Sch Med, Div Hematol Oncol, Indianapolis, IN 46202 USA.4 aut |
700 | 1 | a Wang, Youjinu NCI, Rockville, MD USA.4 aut |
700 | 1 | a Assal, Ameru Columbia Univ, Med Ctr, New York Presbyterian Hosp, New York, NY USA.4 aut |
700 | 1 | a Caro, Paul Castillou UF Hlth Shands Childrens Hosp, Gainesville, FL USA.4 aut |
700 | 1 | a Kuwatsuka, Yachiyou Nagoya Univ Hosp, Dept Adv Med, Nagoya, Aichi, Japan.4 aut |
700 | 1 | a Seo, Sachikou Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan.4 aut |
700 | 1 | a Ustun, Celalettinu Rush Univ, Div Hematol Oncol Cell Therapy, Chicago, IL 60612 USA.4 aut |
700 | 1 | a Politikos, Ioannisu Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.4 aut |
700 | 1 | a Lazarus, Hillard M.u Case Western Reserve Univ, Cleveland, OH 44106 USA.4 aut |
700 | 1 | a Saber, Waelu Med Coll Wisconsin, CIBMTR, Dept Med, Milwaukee, WI 53226 USA.4 aut |
700 | 1 | a Sandmaier, Brenda M.u Univ Washington, Div Med Oncol, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Clin Res Div, 1124 Columbia St, Seattle, WA 98104 USA.4 aut |
700 | 1 | a De Lima, Marcosu Univ Hosp Case Med Ctr, Seidman Canc Ctr, Dept Med, Cleveland, OH USA.4 aut |
700 | 1 | a Litzow, Marku Mayo Clin Rochester, Div Hematol & Transplant Ctr, Rochester, MN USA.4 aut |
700 | 1 | a Bachanova, Veronikau Univ Minnesota, Med Ctr, Blood & Marrow Transplant Program, Minneapolis, MN 55455 USA.4 aut |
700 | 1 | a Weisdorf, Danielu Univ Minnesota, Med Ctr, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA.4 aut |
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773 | 0 | t Haematologicad : Ferrata Storti Foundation (Haematologica)g 105:5, s. 1329-1338q 105:5<1329-1338x 0390-6078x 1592-8721 |
856 | 4 | u https://doi.org/10.3324/haematol.2019.220756y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1436732/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://haematologica.org/article/download/9388/68438 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-412335 |
856 | 4 8 | u https://doi.org/10.3324/haematol.2019.220756 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:143636768 |
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