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Residual disease de...
Residual disease detected by flow cytometry is an independent predictor of survival in childhood acute myeloid leukaemia; results of the NOPHO-AML 2004 study
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- Tierens, Anne (författare)
- Toronto Gen Hosp, Univ Hlth Network, Dept Pathobiol & Lab Med, 200 Elizabeth St,11th Floor, Toronto, ON M5G 2C4, Canada.;Oslo Univ Hosp, Dept Pathol, Oslo, Norway.
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- Bjorklund, Elizabeth (författare)
- Karolinska Univ Hosp, Dept Pathol, Stockholm, Sweden.
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- Siitonen, Sanna (författare)
- Helsinki Univ Cent Hosp, Lab Serv, Hosp Dist Helsinki, Helsinki, Finland.;Helsinki Univ Cent Hosp, Uusimaa Lab, Helsinki, Finland.
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- Marquart, Hanne Vibeke (författare)
- Rigshosp, Dept Clin Immunol, Sect 7631, Copenhagen Univ Hosp, Copenhagen, Denmark.
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- Juergensen, Gitte Wulff (författare)
- Rigshosp, Dept Clin Immunol, Sect 7631, Copenhagen Univ Hosp, Copenhagen, Denmark.
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- Pelliniemi, Tarja-Terttu (författare)
- Laboratories Ltd, Fimlab, Tampere, Finland.
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- Forestier, Erik (författare)
- Umeå universitet,Medicinsk och klinisk genetik
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- Hasle, Henrik (författare)
- Aarhus Univ, Hosp Skejby, Aarhus, Denmark.
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- Jahnukainen, Kirsi (författare)
- Univ Helsinki, Childrens Hosp, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
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- Lausen, Birgitte (författare)
- Rigshosp, Univ Hosp, Copenhagen, Denmark.
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- Jonsson, Olafur G. (författare)
- Landspitali Univ Hosp, Reykjavik, Iceland.
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- Palle, Josefine (författare)
- Uppsala universitet,Pediatrik
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- Zeller, Bem (författare)
- Natl Hosp Norway, Oslo Univ Hosp, Oslo, Norway.
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- Fogelstrand, Linda, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
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- Abrahamsson, Jonas, 1954 (författare)
- Sahlgrens Univ Hosp, Queen Silvia Childrens Hosp, Gothenburg, Sweden.
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Toronto Gen Hosp, Univ Hlth Network, Dept Pathobiol & Lab Med, 200 Elizabeth St,11th Floor, Toronto, ON M5G 2C4, Canada;Oslo Univ Hosp, Dept Pathol, Oslo, Norway. Karolinska Univ Hosp, Dept Pathol, Stockholm, Sweden. (creator_code:org_t)
- 2016-04-13
- 2016
- Engelska.
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Ingår i: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 174:4, s. 600-609
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Early response after induction is a prognostic factor for disease outcome in childhood acute myeloid leukaemia (AML). Residual disease (RD) detection by multiparameter flow cytometry (MFC) was performed at day 15 and before consolidation therapy in 101 patients enrolled in the Nordic Society of Paediatric Haemato-Oncology AML 2004 study. A multicentre laboratory approach to RD analysis was used. Event-free survival (EFS) and overall survival (OS) was significantly different in patients with and without RD at both time points, using a 0.1% RD cut-off level. RD-negative and -positive patients after first induction showed a 5-year EFS of 65.7% and 22.7%, respectively (P < 0.001) and an OS of 77.6% (P = 0.025) and 51.8%. RD-negative and -positive patients at start of consolidation therapy had a 5-year EFS of 57.7% and 11.7%, respectively (P < 0001) and an OS of 786% and 2811%) (P < 0001). In multivariate analysis only RD was significantly correlated with survival. RD before consolidation therapy was the strongest independent prognostic factor for EFS [hazard ratio (HR): 5.0; 95% confidence interval (CI): 1.9-133] and OS (HR: 7.0; 95% CI: 20-245). In conclusion, RD before consolidation therapy identifies patients at high risk of relapse in need of intensified treatment. In addition, RD detection can be performed in a multicentre setting and can be implemented in future trials.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- acute myeloid leukaemia
- flow cytometry
- minimal residual disease
- prognosis
- survival
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Tierens, Anne
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Bjorklund, Eliza ...
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Siitonen, Sanna
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Marquart, Hanne ...
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Juergensen, Gitt ...
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Pelliniemi, Tarj ...
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Forestier, Erik
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Hasle, Henrik
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Jahnukainen, Kir ...
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Lausen, Birgitte
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Jonsson, Olafur ...
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Palle, Josefine
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Zeller, Bem
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Fogelstrand, Lin ...
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Abrahamsson, Jon ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hematologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Pediatrik
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Uppsala universitet
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