WFRF:(Bodahl Sara)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04073nam a2200373 4500 | |
| 001 | oai:lup.lub.lu.se:a97ed58a-d956-4da1-b96c-816bf088f629 | |
| 003 | SwePub | |
| 008 | 220419s2022 | |||||||||||000 ||eng| | |
| 020 | a 9789180212144 | |
| 024 | 7 | a https://lup.lub.lu.se/record/a97ed58a-d956-4da1-b96c-816bf088f6292 URI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a dok2 swepub-publicationtype |
| 072 | 7 | a vet2 swepub-contenttype |
| 100 | 1 | a Bodahl, Sarau Lund University,Lunds universitet,Kärlfysiologi,Forskargrupper vid Lunds universitet,Vascular Physiology,Lund University Research Groups4 aut0 (Swepub:lu)sa8501da |
| 245 | 1 0 | a Effects of the host defense peptide LL-37 on human cells : Immunomodulation and cytotoxicity |
| 264 | 1 | c 2022 |
| 300 | a 69 s. | |
| 338 | a electronic2 rdacarrier | |
| 490 | 0 | a Lund University, Faculty of Medicine Doctoral Dissertation Series,x 1652-8220 |
| 520 | a The human host defense peptide LL-37 has an essential role in the first line of defense against invading pathogens. This cathelicidin is mainly produced by immune cells and epithelial cells aligning the mucosal areas and is normally upregulated upon infection and inflammation. LL-37 displays direct antimicrobial activity against a variety of pathogens, but also modulates the immune responses by acting as a chemoattractant, influencing the production of inflammatory mediators and by affecting immune receptor signaling. Abnormally high local levels of LL-37 have been linked to inflammatory diseases, such as psoriasis, atherosclerosis, periodontitis and asthma. However, little is known about the role of LL-37 in the development and progression of inflammatory and autoimmune diseases and more research is needed to clarify and establish how LL-37 mediates host cell functions in these conditions. In this thesis we have studied LL-37-induced cell toxicity, cell membrane permeability and immune receptor signaling in several types of human cells. We show that LL-37 reduces cell viability in a dose-dependent manner and permeabilizes the cell membranes in all human cell types studied. Interestingly, we demonstrate that LL-37 reduces the cell viability and generates cell membrane permeabilization in osteoblast-like cells even though LL-37 import via clathrin-mediated endocytosis is prevented. In mast cells, LL-37-induced cell membrane permeabilization results in release of both cytosolic and nucleic components, indicating that LL-37 permeabilizes cellular compartments such as the nucleus. Furthermore, we show that LL-37 influences TLR3 signaling in both coronary artery smooth muscle cells and bronchial epithelial cells. More specifically, LL-37 enhances viral dsRNA signaling on TLR3, resulting in upregulation of TLR3 expression and downstream pro-inflammatory signaling that involves the transcription factor NF-κB. Finally, we show that LL-37 induces an increased import of dsRNA in bronchial epithelial cells, suggesting that this mechanism of action is associated with upregulated expression of TLR3. Overall, the work in this thesis provides new insights on underlying mechanisms behind LL-37-induced host cytotoxicity and cell membrane permeability and proposes a novel LL-37-driven pro-inflammatory mechanism of action involving potentiation of dsRNA-stimulated TLR3 expression and signaling | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 653 | a LL-37 | |
| 653 | a Host defense peptides | |
| 653 | a Cathelicidin | |
| 653 | a Inflammation | |
| 653 | a Cytotoxicity | |
| 653 | a TLR3 | |
| 653 | a Poly I:C | |
| 710 | 2 | a Kärlfysiologib Forskargrupper vid Lunds universitet4 org |
| 856 | 4 | u https://portal.research.lu.se/files/116946439/Sara_Bodahl_for_web.pdfx primaryx freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/a97ed58a-d956-4da1-b96c-816bf088f629 |
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