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Sökning: WFRF:(Bozovic I.) > (2020-2024) > A seventeenth-centu...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004662naa a2200445 4500
001oai:lup.lub.lu.se:6562cbd5-1459-41a5-92e7-885b83a7545b
003SwePub
008200820s2020 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/6562cbd5-1459-41a5-92e7-885b83a7545b2 URI
0247 a https://doi.org/10.1186/s13059-020-02112-12 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Sabin, Susannau Max Planck Institute for the Science of Human History4 aut
2451 0a A seventeenth-century Mycobacterium tuberculosis genome supports a Neolithic emergence of the Mycobacterium tuberculosis complex
264 c 2020-08-10
264 1b Springer Science and Business Media LLC,c 2020
520 a BACKGROUND: Although tuberculosis accounts for the highest mortality from a bacterial infection on a global scale, questions persist regarding its origin. One hypothesis based on modern Mycobacterium tuberculosis complex (MTBC) genomes suggests their most recent common ancestor followed human migrations out of Africa approximately 70,000 years before present. However, studies using ancient genomes as calibration points have yielded much younger dates of less than 6000 years. Here, we aim to address this discrepancy through the analysis of the highest-coverage and highest-quality ancient MTBC genome available to date, reconstructed from a calcified lung nodule of Bishop Peder Winstrup of Lund (b. 1605-d. 1679). RESULTS: A metagenomic approach for taxonomic classification of whole DNA content permitted the identification of abundant DNA belonging to the human host and the MTBC, with few non-TB bacterial taxa comprising the background. Genomic enrichment enabled the reconstruction of a 141-fold coverage M. tuberculosis genome. In utilizing this high-quality, high-coverage seventeenth-century genome as a calibration point for dating the MTBC, we employed multiple Bayesian tree models, including birth-death models, which allowed us to model pathogen population dynamics and data sampling strategies more realistically than those based on the coalescent. CONCLUSIONS: The results of our metagenomic analysis demonstrate the unique preservation environment calcified nodules provide for DNA. Importantly, we estimate a most recent common ancestor date for the MTBC of between 2190 and 4501 before present and for Lineage 4 of between 929 and 2084 before present using multiple models, confirming a Neolithic emergence for the MTBC.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653 a Ancient DNA
653 a Metagenomics
653 a Molecular dating
653 a Mycobacterium tuberculosis
653 a Tuberculosis
7001 a Herbig, Alexanderu Max Planck Institute for the Science of Human History4 aut
7001 a Vågene, Åshild J.u Max Planck Institute for the Science of Human History,University of Copenhagen4 aut
7001 a Ahlström, Torbjörnu Lund University,Lunds universitet,Historisk osteologi,Institutionen för arkeologi och antikens historia,Institutioner,Humanistiska och teologiska fakulteterna,Historical Osteology,Department of Archaeology and Ancient History,Departments,Joint Faculties of Humanities and Theology4 aut0 (Swepub:lu)ark-tah
7001 a Bozovic, Gracijelau Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-gbz
7001 a Arcini, Carolineu The Archaeologists, National Historical Museums4 aut0 (Swepub:lu)extLU-984
7001 a Kühnert, Deniseu Max Planck Institute for the Science of Human History4 aut
7001 a Bos, Kirsten I.u Max Planck Institute for the Science of Human History4 aut
7102 a Max Planck Institute for the Science of Human Historyb University of Copenhagen4 org
7730 t Genome Biologyd : Springer Science and Business Media LLCg 21:1q 21:1x 1474-7596x 1474-760X
8564 u http://dx.doi.org/10.1186/s13059-020-02112-1x freey FULLTEXT
8564 u https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-020-02112-1
8564 8u https://lup.lub.lu.se/record/6562cbd5-1459-41a5-92e7-885b83a7545b
8564 8u https://doi.org/10.1186/s13059-020-02112-1

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