Sökning: WFRF:(Brolin Elin B.) > Increased Inflammat...
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000 | 05819naa a2200553 4500 | |
001 | oai:DiVA.org:uu-392574 | |
003 | SwePub | |
008 | 190910s2019 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:141455786 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3925742 URI |
024 | 7 | a https://doi.org/10.1373/clinchem.2018.3010852 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1414557862 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hjort, Marcusu Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)marhj595 |
245 | 1 0 | a Increased Inflammatory Activity in Patients 3 Months after Myocardial Infarction with Nonobstructive Coronary Arteries |
264 | c 2019-08-01 | |
264 | 1 | b AMER ASSOC CLINICAL CHEMISTRY,c 2019 |
338 | a print2 rdacarrier | |
520 | a BACKGROUND: Around 5%-10% of patients with myocardial infarction (MI) present with nonobstructive coronary arteries (MINOCA). We aimed to assess pathophysiological mechanisms in MINOCA by extensively evaluating cardiovascular biomarkers in the stable phase after an event, comparing MINOCA patients with cardiovascular healthy controls and MI patients with obstructive coronary artery disease (MI-CAD).METHODS: Ninety-one biomarkers were measured with a proximity extension assay 3 months after MI in 97 MINOCA patients, 97 age-and sex-matched MI-CAD patients, and 98 controls. Lasso analyses (penalized logistic regression models) and adjusted multiple linear regression models were used for statistical analyses.RESULTS: In the Lasso analysis (MINOCA vs MI-CAD), 8 biomarkers provided discriminatory value: P-selectin glycoprotein ligand 1, C-X-C motif chemokine 1, TNF-related activation-induced cytokine, and pappalysin-1 (PAPPA) with increasing probabilities of MINOCA, and tissue-type plasminogen activator, B-type natriuretic peptide, myeloperoxidase, and interleukin-1 receptor antagonist protein with increasing probabilities of MI-CAD. Comparing MINOCA vs controls, 7 biomarkers provided discriminatory value: N-terminal pro-B-type natriuretic peptide, renin, NF-kappa-B essential modulator, PAPPA, interleukin-6, and soluble urokinase plasminogen activator surface receptor with increasing probabilities of MINOCA, and agouti-related protein with increasing probabilities of controls. Adjusted multiple linear regression analyses showed that group affiliation was associated with the concentrations of 7 of the 8 biomarkers in the comparison MINOCA vs MI-CAD and 5 of the 7 biomarkers in MINOCA vs controls.CONCLUSIONS: Three months after the MI, the biomarker concentrations indicated greater inflammatory activity in MINOCA patients than in both MI-CAD patients and healthy controls, and a varying degree of myocardial dysfunction among the 3 cohorts. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng |
700 | 1 | a Eggers, Kai M.,d 1962-u Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)kaieg561 |
700 | 1 | a Lindhagen, Larsu Karolinska Institutet,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)lla11670 |
700 | 1 | a Agewall, Stefanu Karolinska Institutet,Univ Oslo, Inst Clin Sci, Oslo Univ Hosp, Oslo, Norway4 aut |
700 | 1 | a Brolin, Elin B.u Karolinska Institutet,Soder Sjukhuset, Dept Clin Sci Intervent & Technol, Stockholm, Sweden4 aut |
700 | 1 | a Collste, Olovu Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden4 aut |
700 | 1 | a Daniel, Mariau Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden4 aut |
700 | 1 | a Ekenbäck, Christinau Karolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden4 aut |
700 | 1 | a Frick, Matsu Karolinska Institutet,Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden4 aut |
700 | 1 | a Henareh, Loghmanu Karolinska Univ Hosp, Dept Med, Heart & Vasc Theme, Stockholm, Sweden4 aut |
700 | 1 | a Hofman-Bang, Claesu Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden4 aut |
700 | 1 | a Malmqvist, Karinu Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden4 aut |
700 | 1 | a Spaak, Jonasu Karolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden4 aut |
700 | 1 | a Sörensson, Pederu Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden4 aut |
700 | 1 | a Y-Hassan, Shamsu Karolinska Univ Hosp, Dept Med, Heart & Vasc Theme, Stockholm, Sweden4 aut |
700 | 1 | a Tornvall, Peru Karolinska Institutet,Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden4 aut |
700 | 1 | a Lindahl, Bertil,d 1957-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)belin227 |
710 | 2 | a Uppsala universitetb Uppsala kliniska forskningscentrum (UCR)4 org |
773 | 0 | t Clinical Chemistryd : AMER ASSOC CLINICAL CHEMISTRYg 65:8, s. 1023-1030q 65:8<1023-1030x 0009-9147x 1530-8561 |
856 | 4 | u https://academic.oup.com/clinchem/article-pdf/65/8/1023/32638731/clinchem1023.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-392574 |
856 | 4 8 | u https://doi.org/10.1373/clinchem.2018.301085 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141455786 |
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