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Association between...
Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma
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- Porsbjerg, Celeste M. (författare)
- Bispebjerg Hosp, Dept Resp Med & Infect Dis, Res Unit, Copenhagen, Denmark.,Bispebjerg Hospital
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- Townend, John (författare)
- Vancouver Gen Hosp, Dept Med, Ctr Lung Hlth, Vancouver, BC, Canada.;Univ British Columbia, Dept Med, Vancouver, BC, Canada.
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- Bergeron, Celine (författare)
- Med Univ, Fac Publ Hlth, Sofia, Bulgaria.;Univ Sydney, Woolcock Inst Med Res, Sydney, NSW, Australia.
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visa fler...
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- Christoff, George C. (författare)
- Univ Notre Dame, Sch Med, Sydney Campus, Sydney, NSW, Australia.
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- Katsoulotos, Gregory P. (författare)
- AstraZeneca, BioPharmaceut Med, Gaithersburg, MD USA.
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- Larenas-Linnemann, Desiree (författare)
- King Fahad Med, Dept Pulmonol, Riyadh, Saudi Arabia.
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- Tran, Trung N. (författare)
- Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia.
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- Al-Lehebi, Riyad (författare)
- Macquarie Univ, Macquarie Med Sch, Fac Med Hlth & Human Sci, Sydney, NSW, Australia.;Queens Univ Belfast, Sch Med Dent & Biomed Sci, Ctr Publ Hlth, Belfast, Antrim, North Ireland.
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- Bosnic-Anticevich, Sinthia Z. (författare)
- Hosp Med, Ctr Excelencia Asma & Alergia, Mexico City, DF, Mexico.;Queens Univ Belfast, Sch Med, Ctr Publ Hlth, Dent & Biomed Sci, Belfast, Antrim, North Ireland.
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- Busby, John (författare)
- Alfred Hlth, Allergy Asthma & Clin Immunol Serv, Melbourne, Vic, Australia.
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- Hew, Mark (författare)
- Monash Univ, Publ Hlth & Prevent Med, Melbourne, Vic, Australia.;Univ Ioannina, Dept Resp Med, Ioannina, Greece.
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- Kostikas, Konstantinos (författare)
- Univ Manchester, Div Infect Immun & Resp Med, Manchester, Lancs, England.
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- Papadopoulos, Nikolaos G. (författare)
- Univ Athens, Dept Allergy, Pediat Clin 2, Athens, Greece.;Barts Hlth Natl Hlth Serv NHS Trust, Dept Resp Med, London, England.
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- Pfeffer, Paul E. (författare)
- Queen Mary Univ London, Barts & London Sch Med & Dent, London, England.;Univ Hosp St Ivan Rilski, Sofia, Bulgaria.;Catholic Univ Korea, Seoul St Marys Hosp, Div Pulm & Crit Care Med, Coll Med, Seoul, South Korea.
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- Popov, Todor A. (författare)
- Univ British Columbia, Fac Pharmaceut Sci, Resp Evaluat Sci Program, Vancouver, BC, Canada.,Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark.
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- Rhee, Chin Kook (författare)
- Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Kaohsiung, Taiwan.
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- Sadatsafavi, Mohsen (författare)
- Kaohsiung Med Univ, Sch Med, Coll Med, Dept Internal Med, Kaohsiung, Taiwan.
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- Tsai, Ming-Ju (författare)
- Kuwait Univ, Dept Microbiol, Coll Med, Kuwait, Kuwait.
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- Ulrik, Charlotte Suppli (författare)
- Univ Tartu & Lung Clin, Tartu Univ Hosp, Dept Pulmonol, Tartu, Estonia.
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- Al-Ahmad, Mona (författare)
- Inst Invest Sanitaria Illes Balears IdISB, Son Espases Univ Hosp, Mallorca, Spain.;Bispebjerg Hosp, Resp Res Unit, Copenhagen, Denmark.
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- Altraja, Alan (författare)
- Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark.,Pontificia Univ Javeriana, Sch Med, Bogota, Colombia.;Changi Gen Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.
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Beastall, Aaron (författare)
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Bulathsinhala, Lakmini (författare)
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- Carter, Victoria (författare)
- Vancouver Gen Hosp, Dept Med, Ctr Lung Hlth, Vancouver, BC, Canada.;Univ British Columbia, Dept Med, Vancouver, BC, Canada.
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- Cosio, Borja G. (författare)
- Queens Univ Belfast, Wellcome Wolfson Inst Expt Med, Belfast, Antrim, North Ireland.
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- Fletton, Kirsty (författare)
- Univ British Columbia, Dept Med, Vancouver, BC, Canada.
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- Hansen, Susanne (författare)
- Univ Nottingham, Resp Med Sch Med, Nottingham, England.
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- Heaney, Liam G. (författare)
- Univ Nottingham, Resp Med Sch Med, Nottingham, England.
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- Hubbard, Richard B. (författare)
- Med Univ Lodz, Div Internal Med Asthma & Allergy, Lodz, Poland.
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- Kuna, Piotr (författare)
- Kobe Univ, Grad Sch Med, Dept Internal Med, Div Resp Med, Kobe, Japan.
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- Murray, Ruth B. (författare)
- Univ British Columbia, Dept Med, Vancouver, BC, Canada.
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- Nagano, Tatsuya (författare)
- Univ Brescia, Spedali Civili Brescia, Dept Clin & Expt Sci, Brescia, Italy.
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- Pini, Laura (författare)
- Inst Neumol Oriente, Bucaramanga, Colombia.
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- Rosales, Diana Jimena Cano (författare)
- Univ Liege, Ctr Hosp Univ CHU Sart Tilman, GIGA I3, Liege, Belgium.
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- Schleich, Florence (författare)
- Univ Liege, Liege, Belgium.
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- Wechsler, Michael E. (författare)
- Natl Jewish Hlth NJH, Cohen Family Asthma Inst, Dept Med, Denver, CO USA.
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- Amaral, Rita (författare)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Univ Porto, CINTESIS RISE, MEDCIDS, Fac Med, Porto, Portugal.
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- Bourdin, Arnaud (författare)
- Univ Montpellier, Natl Inst Hlth & Med Res INSERM, Ctr Hosp Univ CHU Montpellier, Natl Ctr Sci Res CNRS, Montpellier, France.
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- Brusselle, Guy G. (författare)
- Ghent Univ Hosp, Dept Resp Med, Ghent, Belgium.;Erasmus MC, Dept Epidemiol & Resp Med, Rotterdam, Netherlands.
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- Chen, Wenjia (författare)
- Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.
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- Chung, Li Ping (författare)
- Fiona Stanley Hosp, Dept Resp Med, Perth, WA, Australia.
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- Denton, Eve (författare)
- Monash Univ, Cent Clin Sch, Med, Melbourne, Vic, Australia.
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Fonseca, Joao A. (författare)
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- Hoyte, Flavia (författare)
- Natl Jewish Hlth, Dept Med, Div Allergy & Clin Immunol, Denver, CO USA.
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- Jackson, David J. (författare)
- Kings Coll London, Guys Hosp, Guys Severe Asthma Ctr, London, England.
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Katial, Rohit (författare)
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- Kirenga, Bruce J. (författare)
- Makerere Univ, Lung Inst, Dept Med, Kampala, Uganda.
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- Koh, Mariko Siyue (författare)
- Singapore Gen Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.
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- Lawkiedraj, Agnieszka (författare)
- Singapore Gen Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.;Tampere Univ Hosp, Allergy Ctr, Tampere, Finland.
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- Bjermer, L. (författare)
- Lund University,Lunds universitet,Klinisk lungmedicin,Forskargrupper vid Lunds universitet,Clinical Respiratory Medicine,Lund University Research Groups,Skåne University Hospital,Univ Paris Cite, Bichat Hosp, AP HP, Dept Resp Dis, Paris, France.
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- Liew, Mei Fong (författare)
- Tampere Univ, Fac Med & Hlth Technol, Tampere, Finland.;Natl Univ Hlth Syst, Alexandra Hosp, FAST & Chron Programmes, Singapore, Singapore.
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- Mahboub, Bassam (författare)
- Natl Univ Hlth Syst, Natl Univ Hosp, Dept Med, Div Resp & Crit Care Med, Singapore, Singapore.;Dubai Hlth Author DHA, Rashid Hosp, Dubai, U Arab Emirates.
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- Martin, Neil (författare)
- Dubai Acad & Hlth Corp, Dubai, U Arab Emirates.
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- Menzies-Gow, Andrew N. (författare)
- Univ Leicester, Dept Resp Med, Leicester, Leics, England.;AstraZeneca, BioPharmaceut Med, Cambridge, England.
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- Pang, Pee Hwee (författare)
- Royal Brompton & Harefield Hosp, Lung Div, London, England.
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- Papaioannou, Andriana I. (författare)
- Tan Tock Seng Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.
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- Patel, Pujan H. (författare)
- Tan Tock Seng Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.
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- Perez-De-Llano, Luis (författare)
- Attikon Univ, Attikon Univ Hosp, Resp Med Dept 2, Athens, Greece.
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- Peters, Matthew J. (författare)
- Royal Brompton Hosp, Resp Med, London, England.;Lucus Augusti Univ Hosp, Serv Pneumol, Sergas Galician Healthcare Serv Integrated Manage, Cervo, Spain.
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- Ricciardi, Luisa (författare)
- Concord Hosp, Dept Thorac Med, Sydney, NSW, Australia.
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Rodriguez-Caceres, Bellanid (författare)
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- Solarte, Ivan (författare)
- Macquarie Univ, Fac Med Hlth & Human Sci, Sydney, NSW, Australia.;Univ Messina, G Martino Hosp, Allergy & Clin Immunol, Messina, Italy.
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- Tay, Tunn Ren (författare)
- Hosp Univ San Ignacio, Pulm Unit, Bogota, Colombia.
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- Torres-Duque, Carlos A. (författare)
- Pontificia Univ Javeriana, Sch Med, Bogota, Colombia.;Changi Gen Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.
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Wang, Eileen (författare)
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- Zappa, Martina (författare)
- Fdn Neumolo Colombiana, Resp Res Ctr, Ctr Internac Invest Neumol CINEUMO, Bogota, Colombia.
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- Abisheganaden, John (författare)
- Univ La Sabana, Doctoral Biosci, Chia, Colombia.;Univ Colorado, Dept Med, Div Allergy & Clin Immunol, Sch Med, Aurora, CO USA.
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- Assing, Karin Dahl (författare)
- Univ Insubria, Dept Med & Surg, Varese, Italy.
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- Costello, Richard W. (författare)
- Natl Healthcare Grp, Hlth Serv & Outcomes Res, Singapore, Singapore.
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- Gibson, Peter G. (författare)
- Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore.;Aalborg Univ Hosp, Dept Resp Med, Aalborg, Denmark.
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- Heffler, Enrico (författare)
- Royal Coll Surg Ireland RCSI, Smurfit Bldg Beaumont Hosp, Clin Res Ctr, Dept Resp Med, Dublin, Ireland.;Univ Newcastle, Prior Res Ctr Healthy Lungs, Australian Severe Asthma Network, Newcastle, NSW, Australia.
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- Maspero, Jorge (författare)
- Hunter Med Res Inst, John Hunter Hosp, Dept Resp & Sleep Med, Newcastle, NSW, Australia.;Humanitas Canc Ctr IRCCS Humanitas Res Hosp, Ist Clin Humanitas, Personalized Med Asthma & Allergy, Rozzano, Italy.
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- Nicola, Stefania (författare)
- Humanitas Univ, Dept Biomed Sci, Pieve Emanuele, Italy.
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- Steve, Diahn-Warng Perng (författare)
- CIDEA Fdn, Clin Res Allergy & Resp Med, Buenos Aires, DF, Argentina.;Univ Buenos Aires, Univ Career Specialists Allergy & Clin Immunol, Allergy & Immunol Unit, Sch Med, Buenos Aires, DF, Argentina.
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Puggioni, Francesca (författare)
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- Salvi, Sundeep (författare)
- Natl Yang Ming Chiao Tung Univ, Sch Med, Taipei, Taiwan.
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Sheu, Chau-Chyun (författare)
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- Sirena, Concetta (författare)
- Taipei Vet Gen Hosp, Dept Chest Med, Taipei, Taiwan.
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- Taille, Camille (författare)
- Pulmocare Res & Educ Fdn, Pune, Maharashtra, India.
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- Tan, Tze Lee (författare)
- Severe Asthma Network Italy SANI, Milan, Italy.
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- Bjermer, Leif (författare)
- Univ Paris Cite, Bichat Hosp, AP HP, Dept Resp Dis, Paris, France.
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- Canonica, Giorgio Walter (författare)
- Royal Coll Surg Ireland RCSI, Smurfit Bldg Beaumont Hosp, Clin Res Ctr, Dept Resp Med, Dublin, Ireland.;Univ Newcastle, Prior Res Ctr Healthy Lungs, Australian Severe Asthma Network, Newcastle, NSW, Australia.
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- Iwanaga, Takashi (författare)
- Natl Univ Hlth Syst, Dept Family Med, Singapore, Singapore.
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- Jimenez-Maldonado, Libardo (författare)
- Lund Univ, Skane Univ Hosp, Dept Clin Sci, Resp Med & Allergol, Lund, Sweden.
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- Taube, Christian (författare)
- Kindai Univ Hosp, Osakasayama, Japan.;Univ Turin, Dept Med Sci, Turin, Italy.
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- Brussino, Luisa (författare)
- Fdn Neumol Colombiana, ASMAIRE REXPIRA Atenc Integral & Rehabil Asma Or, Bogota, Colombia.;Univ Aberdeen, Ctr Acad Primary Care, Div Appl Hlth Sci, Aberdeen, Scotland.
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- Price, David B. (författare)
- Univ Med Ctr Essen Ruhrlandklin, Dept Pulm Med, Essen, Germany.,Observational and Pragmatic Research Institute Pte Ltd,Optimum Patient Care Global,University of Aberdeen
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- Lehtimaki, Lauri (författare)
- Univ Lodz, Lodz, Poland.
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Bispebjerg Hosp, Dept Resp Med & Infect Dis, Res Unit, Copenhagen, Denmark Bispebjerg Hospital (creator_code:org_t)
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et al
- Frontiers Media S.A. 2024
- 2024
- Engelska.
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Ingår i: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 15
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: To date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials.Aim: To elucidate the associations of pre-biologic individual biomarker levels or their combinations with pre-to-post biologic changes in asthma outcomes in real-life.Methods: This was a registry-based, cohort study using data from 23 countries, which shared data with the International Severe Asthma Registry (May 2017-February 2023). The investigated biomarkers (highest pre-biologic levels) were immunoglobulin E (IgE), blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO). Pre- to approximately 12-month post-biologic change for each of three asthma outcome domains (i.e. exacerbation rate, symptom control and lung function), and the association of this change with pre-biologic biomarkers was investigated for individual and combined biomarkers.Results: Overall, 3751 patients initiated biologics and were included in the analysis. No association was found between pre-biologic BEC and pre-to-post biologic change in exacerbation rate for any biologic class. However, higher pre-biologic BEC and FeNO were both associated with greater post-biologic improvement in FEV1 for both anti-IgE and anti-IL5/5R, with a trend for antiI-IL4R alpha. Mean FEV1 improved by 27-178 mL post-anti-IgE as pre-biologic BEC increased (250 to 1000 cells/mu L), and by 43-216 mL and 129-250 mL post-anti-IL5/5R and - anti- IL4R alpha, respectively along the same BEC gradient. Corresponding improvements along a FeNO gradient (25-100 ppb) were 41-274 mL, 69-207 mL and 148-224 mL for anti-IgE, anti-IL5/5R, and anti-IL4R alpha, respectively. Higher baseline BEC was also associated with lower probability of uncontrolled asthma (OR 0.392; p=0.001) post-biologic for anti-IL5/5R. Pre-biologic IgE was a poor predictor of subsequent pre-to-post-biologic change for all outcomes assessed for all biologics. The combination of BEC + FeNO marginally improved the prediction of post-biologic FEV1 increase (adjusted R-2: 0.751), compared to BEC (adjusted R-2: 0.747) or FeNO alone (adjusted R-2: 0.743) (p=0.005 and <0.001, respectively); however, this prediction was not improved by the addition of IgE.Conclusions: The ability of higher baseline BEC, FeNO and their combination to predict biologic-associated lung function improvement may encourage earlier intervention in patients with impaired lung function or at risk of accelerated lung function decline.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- severe asthma
- biomarkers
- eosinophil (EOS)
- FeNO (Fraction of exhaled Nitric Oxide)
- biologics
- FEV1
- personalized medicine (PM)
- biologics
- biomarkers
- eosinophil (EOS)
- FeNO (Fraction of exhaled Nitric Oxide)
- FEV1
- personalized medicine (PM)
- severe asthma
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Porsbjerg, Celes ...
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Townend, John
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Bergeron, Celine
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Christoff, Georg ...
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Katsoulotos, Gre ...
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Larenas-Linneman ...
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visa fler...
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Tran, Trung N.
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Al-Lehebi, Riyad
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Bosnic-Anticevic ...
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Busby, John
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Hew, Mark
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Kostikas, Konsta ...
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Papadopoulos, Ni ...
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Pfeffer, Paul E.
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Popov, Todor A.
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Rhee, Chin Kook
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Sadatsafavi, Moh ...
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Tsai, Ming-Ju
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Ulrik, Charlotte ...
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Al-Ahmad, Mona
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Altraja, Alan
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Beastall, Aaron
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Bulathsinhala, L ...
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Carter, Victoria
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Cosio, Borja G.
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Fletton, Kirsty
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Hansen, Susanne
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Heaney, Liam G.
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Hubbard, Richard ...
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Kuna, Piotr
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Murray, Ruth B.
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Nagano, Tatsuya
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Pini, Laura
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Rosales, Diana J ...
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Schleich, Floren ...
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Wechsler, Michae ...
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Amaral, Rita
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Bourdin, Arnaud
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Brusselle, Guy G ...
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Chen, Wenjia
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Chung, Li Ping
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Denton, Eve
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Fonseca, Joao A.
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Hoyte, Flavia
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Jackson, David J ...
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Katial, Rohit
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Kirenga, Bruce J ...
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Koh, Mariko Siyu ...
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Lawkiedraj, Agni ...
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Bjermer, L.
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Liew, Mei Fong
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Mahboub, Bassam
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Martin, Neil
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Menzies-Gow, And ...
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Pang, Pee Hwee
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Papaioannou, And ...
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Patel, Pujan H.
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Perez-De-Llano, ...
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Peters, Matthew ...
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Ricciardi, Luisa
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Rodriguez-Cacere ...
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Solarte, Ivan
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Tay, Tunn Ren
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Torres-Duque, Ca ...
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Wang, Eileen
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Zappa, Martina
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Abisheganaden, J ...
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Assing, Karin Da ...
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Costello, Richar ...
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Gibson, Peter G.
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Heffler, Enrico
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Maspero, Jorge
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Nicola, Stefania
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Steve, Diahn-War ...
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Puggioni, France ...
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Salvi, Sundeep
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Sheu, Chau-Chyun
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Sirena, Concetta
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Taille, Camille
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Tan, Tze Lee
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Bjermer, Leif
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Canonica, Giorgi ...
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Iwanaga, Takashi
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Jimenez-Maldonad ...
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Taube, Christian
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Brussino, Luisa
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Price, David B.
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Lehtimaki, Lauri
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Uppsala universitet
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