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Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma

Porsbjerg, Celeste M. (författare)
Bispebjerg Hosp, Dept Resp Med & Infect Dis, Res Unit, Copenhagen, Denmark.,Bispebjerg Hospital
Townend, John (författare)
Vancouver Gen Hosp, Dept Med, Ctr Lung Hlth, Vancouver, BC, Canada.;Univ British Columbia, Dept Med, Vancouver, BC, Canada.
Bergeron, Celine (författare)
Med Univ, Fac Publ Hlth, Sofia, Bulgaria.;Univ Sydney, Woolcock Inst Med Res, Sydney, NSW, Australia.
visa fler...
Christoff, George C. (författare)
Univ Notre Dame, Sch Med, Sydney Campus, Sydney, NSW, Australia.
Katsoulotos, Gregory P. (författare)
AstraZeneca, BioPharmaceut Med, Gaithersburg, MD USA.
Larenas-Linnemann, Desiree (författare)
King Fahad Med, Dept Pulmonol, Riyadh, Saudi Arabia.
Tran, Trung N. (författare)
Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia.
Al-Lehebi, Riyad (författare)
Macquarie Univ, Macquarie Med Sch, Fac Med Hlth & Human Sci, Sydney, NSW, Australia.;Queens Univ Belfast, Sch Med Dent & Biomed Sci, Ctr Publ Hlth, Belfast, Antrim, North Ireland.
Bosnic-Anticevich, Sinthia Z. (författare)
Hosp Med, Ctr Excelencia Asma & Alergia, Mexico City, DF, Mexico.;Queens Univ Belfast, Sch Med, Ctr Publ Hlth, Dent & Biomed Sci, Belfast, Antrim, North Ireland.
Busby, John (författare)
Alfred Hlth, Allergy Asthma & Clin Immunol Serv, Melbourne, Vic, Australia.
Hew, Mark (författare)
Monash Univ, Publ Hlth & Prevent Med, Melbourne, Vic, Australia.;Univ Ioannina, Dept Resp Med, Ioannina, Greece.
Kostikas, Konstantinos (författare)
Univ Manchester, Div Infect Immun & Resp Med, Manchester, Lancs, England.
Papadopoulos, Nikolaos G. (författare)
Univ Athens, Dept Allergy, Pediat Clin 2, Athens, Greece.;Barts Hlth Natl Hlth Serv NHS Trust, Dept Resp Med, London, England.
Pfeffer, Paul E. (författare)
Queen Mary Univ London, Barts & London Sch Med & Dent, London, England.;Univ Hosp St Ivan Rilski, Sofia, Bulgaria.;Catholic Univ Korea, Seoul St Marys Hosp, Div Pulm & Crit Care Med, Coll Med, Seoul, South Korea.
Popov, Todor A. (författare)
Univ British Columbia, Fac Pharmaceut Sci, Resp Evaluat Sci Program, Vancouver, BC, Canada.,Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark.
Rhee, Chin Kook (författare)
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Kaohsiung, Taiwan.
Sadatsafavi, Mohsen (författare)
Kaohsiung Med Univ, Sch Med, Coll Med, Dept Internal Med, Kaohsiung, Taiwan.
Tsai, Ming-Ju (författare)
Kuwait Univ, Dept Microbiol, Coll Med, Kuwait, Kuwait.
Ulrik, Charlotte Suppli (författare)
Univ Tartu & Lung Clin, Tartu Univ Hosp, Dept Pulmonol, Tartu, Estonia.
Al-Ahmad, Mona (författare)
Inst Invest Sanitaria Illes Balears IdISB, Son Espases Univ Hosp, Mallorca, Spain.;Bispebjerg Hosp, Resp Res Unit, Copenhagen, Denmark.
Altraja, Alan (författare)
Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark.,Pontificia Univ Javeriana, Sch Med, Bogota, Colombia.;Changi Gen Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.
Beastall, Aaron (författare)
Bulathsinhala, Lakmini (författare)
Carter, Victoria (författare)
Vancouver Gen Hosp, Dept Med, Ctr Lung Hlth, Vancouver, BC, Canada.;Univ British Columbia, Dept Med, Vancouver, BC, Canada.
Cosio, Borja G. (författare)
Queens Univ Belfast, Wellcome Wolfson Inst Expt Med, Belfast, Antrim, North Ireland.
Fletton, Kirsty (författare)
Univ British Columbia, Dept Med, Vancouver, BC, Canada.
Hansen, Susanne (författare)
Univ Nottingham, Resp Med Sch Med, Nottingham, England.
Heaney, Liam G. (författare)
Univ Nottingham, Resp Med Sch Med, Nottingham, England.
Hubbard, Richard B. (författare)
Med Univ Lodz, Div Internal Med Asthma & Allergy, Lodz, Poland.
Kuna, Piotr (författare)
Kobe Univ, Grad Sch Med, Dept Internal Med, Div Resp Med, Kobe, Japan.
Murray, Ruth B. (författare)
Univ British Columbia, Dept Med, Vancouver, BC, Canada.
Nagano, Tatsuya (författare)
Univ Brescia, Spedali Civili Brescia, Dept Clin & Expt Sci, Brescia, Italy.
Pini, Laura (författare)
Inst Neumol Oriente, Bucaramanga, Colombia.
Rosales, Diana Jimena Cano (författare)
Univ Liege, Ctr Hosp Univ CHU Sart Tilman, GIGA I3, Liege, Belgium.
Schleich, Florence (författare)
Univ Liege, Liege, Belgium.
Wechsler, Michael E. (författare)
Natl Jewish Hlth NJH, Cohen Family Asthma Inst, Dept Med, Denver, CO USA.
Amaral, Rita (författare)
Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Univ Porto, CINTESIS RISE, MEDCIDS, Fac Med, Porto, Portugal.
Bourdin, Arnaud (författare)
Univ Montpellier, Natl Inst Hlth & Med Res INSERM, Ctr Hosp Univ CHU Montpellier, Natl Ctr Sci Res CNRS, Montpellier, France.
Brusselle, Guy G. (författare)
Ghent Univ Hosp, Dept Resp Med, Ghent, Belgium.;Erasmus MC, Dept Epidemiol & Resp Med, Rotterdam, Netherlands.
Chen, Wenjia (författare)
Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.
Chung, Li Ping (författare)
Fiona Stanley Hosp, Dept Resp Med, Perth, WA, Australia.
Denton, Eve (författare)
Monash Univ, Cent Clin Sch, Med, Melbourne, Vic, Australia.
Fonseca, Joao A. (författare)
Hoyte, Flavia (författare)
Natl Jewish Hlth, Dept Med, Div Allergy & Clin Immunol, Denver, CO USA.
Jackson, David J. (författare)
Kings Coll London, Guys Hosp, Guys Severe Asthma Ctr, London, England.
Katial, Rohit (författare)
Kirenga, Bruce J. (författare)
Makerere Univ, Lung Inst, Dept Med, Kampala, Uganda.
Koh, Mariko Siyue (författare)
Singapore Gen Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.
Lawkiedraj, Agnieszka (författare)
Singapore Gen Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.;Tampere Univ Hosp, Allergy Ctr, Tampere, Finland.
Bjermer, L. (författare)
Lund University,Lunds universitet,Klinisk lungmedicin,Forskargrupper vid Lunds universitet,Clinical Respiratory Medicine,Lund University Research Groups,Skåne University Hospital,Univ Paris Cite, Bichat Hosp, AP HP, Dept Resp Dis, Paris, France.
Liew, Mei Fong (författare)
Tampere Univ, Fac Med & Hlth Technol, Tampere, Finland.;Natl Univ Hlth Syst, Alexandra Hosp, FAST & Chron Programmes, Singapore, Singapore.
Mahboub, Bassam (författare)
Natl Univ Hlth Syst, Natl Univ Hosp, Dept Med, Div Resp & Crit Care Med, Singapore, Singapore.;Dubai Hlth Author DHA, Rashid Hosp, Dubai, U Arab Emirates.
Martin, Neil (författare)
Dubai Acad & Hlth Corp, Dubai, U Arab Emirates.
Menzies-Gow, Andrew N. (författare)
Univ Leicester, Dept Resp Med, Leicester, Leics, England.;AstraZeneca, BioPharmaceut Med, Cambridge, England.
Pang, Pee Hwee (författare)
Royal Brompton & Harefield Hosp, Lung Div, London, England.
Papaioannou, Andriana I. (författare)
Tan Tock Seng Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.
Patel, Pujan H. (författare)
Tan Tock Seng Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.
Perez-De-Llano, Luis (författare)
Attikon Univ, Attikon Univ Hosp, Resp Med Dept 2, Athens, Greece.
Peters, Matthew J. (författare)
Royal Brompton Hosp, Resp Med, London, England.;Lucus Augusti Univ Hosp, Serv Pneumol, Sergas Galician Healthcare Serv Integrated Manage, Cervo, Spain.
Ricciardi, Luisa (författare)
Concord Hosp, Dept Thorac Med, Sydney, NSW, Australia.
Rodriguez-Caceres, Bellanid (författare)
Solarte, Ivan (författare)
Macquarie Univ, Fac Med Hlth & Human Sci, Sydney, NSW, Australia.;Univ Messina, G Martino Hosp, Allergy & Clin Immunol, Messina, Italy.
Tay, Tunn Ren (författare)
Hosp Univ San Ignacio, Pulm Unit, Bogota, Colombia.
Torres-Duque, Carlos A. (författare)
Pontificia Univ Javeriana, Sch Med, Bogota, Colombia.;Changi Gen Hosp, Dept Resp & Crit Care Med, Singapore, Singapore.
Wang, Eileen (författare)
Zappa, Martina (författare)
Fdn Neumolo Colombiana, Resp Res Ctr, Ctr Internac Invest Neumol CINEUMO, Bogota, Colombia.
Abisheganaden, John (författare)
Univ La Sabana, Doctoral Biosci, Chia, Colombia.;Univ Colorado, Dept Med, Div Allergy & Clin Immunol, Sch Med, Aurora, CO USA.
Assing, Karin Dahl (författare)
Univ Insubria, Dept Med & Surg, Varese, Italy.
Costello, Richard W. (författare)
Natl Healthcare Grp, Hlth Serv & Outcomes Res, Singapore, Singapore.
Gibson, Peter G. (författare)
Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore.;Aalborg Univ Hosp, Dept Resp Med, Aalborg, Denmark.
Heffler, Enrico (författare)
Royal Coll Surg Ireland RCSI, Smurfit Bldg Beaumont Hosp, Clin Res Ctr, Dept Resp Med, Dublin, Ireland.;Univ Newcastle, Prior Res Ctr Healthy Lungs, Australian Severe Asthma Network, Newcastle, NSW, Australia.
Maspero, Jorge (författare)
Hunter Med Res Inst, John Hunter Hosp, Dept Resp & Sleep Med, Newcastle, NSW, Australia.;Humanitas Canc Ctr IRCCS Humanitas Res Hosp, Ist Clin Humanitas, Personalized Med Asthma & Allergy, Rozzano, Italy.
Nicola, Stefania (författare)
Humanitas Univ, Dept Biomed Sci, Pieve Emanuele, Italy.
Steve, Diahn-Warng Perng (författare)
CIDEA Fdn, Clin Res Allergy & Resp Med, Buenos Aires, DF, Argentina.;Univ Buenos Aires, Univ Career Specialists Allergy & Clin Immunol, Allergy & Immunol Unit, Sch Med, Buenos Aires, DF, Argentina.
Puggioni, Francesca (författare)
Salvi, Sundeep (författare)
Natl Yang Ming Chiao Tung Univ, Sch Med, Taipei, Taiwan.
Sheu, Chau-Chyun (författare)
Sirena, Concetta (författare)
Taipei Vet Gen Hosp, Dept Chest Med, Taipei, Taiwan.
Taille, Camille (författare)
Pulmocare Res & Educ Fdn, Pune, Maharashtra, India.
Tan, Tze Lee (författare)
Severe Asthma Network Italy SANI, Milan, Italy.
Bjermer, Leif (författare)
Univ Paris Cite, Bichat Hosp, AP HP, Dept Resp Dis, Paris, France.
Canonica, Giorgio Walter (författare)
Royal Coll Surg Ireland RCSI, Smurfit Bldg Beaumont Hosp, Clin Res Ctr, Dept Resp Med, Dublin, Ireland.;Univ Newcastle, Prior Res Ctr Healthy Lungs, Australian Severe Asthma Network, Newcastle, NSW, Australia.
Iwanaga, Takashi (författare)
Natl Univ Hlth Syst, Dept Family Med, Singapore, Singapore.
Jimenez-Maldonado, Libardo (författare)
Lund Univ, Skane Univ Hosp, Dept Clin Sci, Resp Med & Allergol, Lund, Sweden.
Taube, Christian (författare)
Kindai Univ Hosp, Osakasayama, Japan.;Univ Turin, Dept Med Sci, Turin, Italy.
Brussino, Luisa (författare)
Fdn Neumol Colombiana, ASMAIRE REXPIRA Atenc Integral & Rehabil Asma Or, Bogota, Colombia.;Univ Aberdeen, Ctr Acad Primary Care, Div Appl Hlth Sci, Aberdeen, Scotland.
Price, David B. (författare)
Univ Med Ctr Essen Ruhrlandklin, Dept Pulm Med, Essen, Germany.,Observational and Pragmatic Research Institute Pte Ltd,Optimum Patient Care Global,University of Aberdeen
Lehtimaki, Lauri (författare)
Univ Lodz, Lodz, Poland.
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Bispebjerg Hosp, Dept Resp Med & Infect Dis, Res Unit, Copenhagen, Denmark Bispebjerg Hospital (creator_code:org_t)
et al 
Frontiers Media S.A. 2024
2024
Engelska.
Ingår i: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 15
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: To date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials.Aim: To elucidate the associations of pre-biologic individual biomarker levels or their combinations with pre-to-post biologic changes in asthma outcomes in real-life.Methods: This was a registry-based, cohort study using data from 23 countries, which shared data with the International Severe Asthma Registry (May 2017-February 2023). The investigated biomarkers (highest pre-biologic levels) were immunoglobulin E (IgE), blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO). Pre- to approximately 12-month post-biologic change for each of three asthma outcome domains (i.e. exacerbation rate, symptom control and lung function), and the association of this change with pre-biologic biomarkers was investigated for individual and combined biomarkers.Results: Overall, 3751 patients initiated biologics and were included in the analysis. No association was found between pre-biologic BEC and pre-to-post biologic change in exacerbation rate for any biologic class. However, higher pre-biologic BEC and FeNO were both associated with greater post-biologic improvement in FEV1 for both anti-IgE and anti-IL5/5R, with a trend for antiI-IL4R alpha. Mean FEV1 improved by 27-178 mL post-anti-IgE as pre-biologic BEC increased (250 to 1000 cells/mu L), and by 43-216 mL and 129-250 mL post-anti-IL5/5R and - anti- IL4R alpha, respectively along the same BEC gradient. Corresponding improvements along a FeNO gradient (25-100 ppb) were 41-274 mL, 69-207 mL and 148-224 mL for anti-IgE, anti-IL5/5R, and anti-IL4R alpha, respectively. Higher baseline BEC was also associated with lower probability of uncontrolled asthma (OR 0.392; p=0.001) post-biologic for anti-IL5/5R. Pre-biologic IgE was a poor predictor of subsequent pre-to-post-biologic change for all outcomes assessed for all biologics. The combination of BEC + FeNO marginally improved the prediction of post-biologic FEV1 increase (adjusted R-2: 0.751), compared to BEC (adjusted R-2: 0.747) or FeNO alone (adjusted R-2: 0.743) (p=0.005 and <0.001, respectively); however, this prediction was not improved by the addition of IgE.Conclusions: The ability of higher baseline BEC, FeNO and their combination to predict biologic-associated lung function improvement may encourage earlier intervention in patients with impaired lung function or at risk of accelerated lung function decline.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Nyckelord

severe asthma
biomarkers
eosinophil (EOS)
FeNO (Fraction of exhaled Nitric Oxide)
biologics
FEV1
personalized medicine (PM)
biologics
biomarkers
eosinophil (EOS)
FeNO (Fraction of exhaled Nitric Oxide)
FEV1
personalized medicine (PM)
severe asthma

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Porsbjerg, Celes ...
Townend, John
Bergeron, Celine
Christoff, Georg ...
Katsoulotos, Gre ...
Larenas-Linneman ...
visa fler...
Tran, Trung N.
Al-Lehebi, Riyad
Bosnic-Anticevic ...
Busby, John
Hew, Mark
Kostikas, Konsta ...
Papadopoulos, Ni ...
Pfeffer, Paul E.
Popov, Todor A.
Rhee, Chin Kook
Sadatsafavi, Moh ...
Tsai, Ming-Ju
Ulrik, Charlotte ...
Al-Ahmad, Mona
Altraja, Alan
Beastall, Aaron
Bulathsinhala, L ...
Carter, Victoria
Cosio, Borja G.
Fletton, Kirsty
Hansen, Susanne
Heaney, Liam G.
Hubbard, Richard ...
Kuna, Piotr
Murray, Ruth B.
Nagano, Tatsuya
Pini, Laura
Rosales, Diana J ...
Schleich, Floren ...
Wechsler, Michae ...
Amaral, Rita
Bourdin, Arnaud
Brusselle, Guy G ...
Chen, Wenjia
Chung, Li Ping
Denton, Eve
Fonseca, Joao A.
Hoyte, Flavia
Jackson, David J ...
Katial, Rohit
Kirenga, Bruce J ...
Koh, Mariko Siyu ...
Lawkiedraj, Agni ...
Bjermer, L.
Liew, Mei Fong
Mahboub, Bassam
Martin, Neil
Menzies-Gow, And ...
Pang, Pee Hwee
Papaioannou, And ...
Patel, Pujan H.
Perez-De-Llano, ...
Peters, Matthew ...
Ricciardi, Luisa
Rodriguez-Cacere ...
Solarte, Ivan
Tay, Tunn Ren
Torres-Duque, Ca ...
Wang, Eileen
Zappa, Martina
Abisheganaden, J ...
Assing, Karin Da ...
Costello, Richar ...
Gibson, Peter G.
Heffler, Enrico
Maspero, Jorge
Nicola, Stefania
Steve, Diahn-War ...
Puggioni, France ...
Salvi, Sundeep
Sheu, Chau-Chyun
Sirena, Concetta
Taille, Camille
Tan, Tze Lee
Bjermer, Leif
Canonica, Giorgi ...
Iwanaga, Takashi
Jimenez-Maldonad ...
Taube, Christian
Brussino, Luisa
Price, David B.
Lehtimaki, Lauri
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