WFRF:(Cargnello M)
Search: WFRF:(Cargnello M) > mTORC1 and CK2 coor...
- 2 of 6
- Previous record
- Next record
- To hitlist
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02754naa a2200481 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:133315693 | |
| 003 | SwePub | |
| 008 | 240701s2016 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1333156932 URI |
| 024 | 7 | a https://doi.org/10.1038/ncomms111272 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Gandin, V4 aut |
| 245 | 1 0 | a mTORC1 and CK2 coordinate ternary and eIF4F complex assembly |
| 264 | c 2016-04-04 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2016 |
| 520 | a Ternary complex (TC) and eIF4F complex assembly are the two major rate-limiting steps in translation initiation regulated by eIF2α phosphorylation and the mTOR/4E-BP pathway, respectively. How TC and eIF4F assembly are coordinated, however, remains largely unknown. We show that mTOR suppresses translation of mRNAs activated under short-term stress wherein TC recycling is attenuated by eIF2α phosphorylation. During acute nutrient or growth factor stimulation, mTORC1 induces eIF2β phosphorylation and recruitment of NCK1 to eIF2, decreases eIF2α phosphorylation and bolsters TC recycling. Accordingly, eIF2β mediates the effect of mTORC1 on protein synthesis and proliferation. In addition, we demonstrate a formerly undocumented role for CK2 in regulation of translation initiation, whereby CK2 stimulates phosphorylation of eIF2β and simultaneously bolsters eIF4F complex assembly via the mTORC1/4E-BP pathway. These findings imply a previously unrecognized mode of translation regulation, whereby mTORC1 and CK2 coordinate TC and eIF4F complex assembly to stimulate cell proliferation. | |
| 700 | 1 | a Masvidal, Lu Karolinska Institutet4 aut |
| 700 | 1 | a Cargnello, M4 aut |
| 700 | 1 | a Gyenis, L4 aut |
| 700 | 1 | a McLaughlan, S4 aut |
| 700 | 1 | a Cai, YT4 aut |
| 700 | 1 | a Tenkerian, C4 aut |
| 700 | 1 | a Morita, M4 aut |
| 700 | 1 | a Balanathan, P4 aut |
| 700 | 1 | a Jean-Jean, O4 aut |
| 700 | 1 | a Stambolic, V4 aut |
| 700 | 1 | a Trost, M4 aut |
| 700 | 1 | a Furic, L4 aut |
| 700 | 1 | a Larose, L4 aut |
| 700 | 1 | a Koromilas, AE4 aut |
| 700 | 1 | a Asano, K4 aut |
| 700 | 1 | a Litchfield, D4 aut |
| 700 | 1 | a Larsson, Ou Karolinska Institutet4 aut |
| 700 | 1 | a Topisirovic, I4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 7, s. 11127-q 7<11127-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/ncomms11127.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:133315693 |
| 856 | 4 8 | u https://doi.org/10.1038/ncomms11127 |
Find in a library
- Nature communications (Search for host publication in LIBRIS)
To the university's database
- 2 of 6
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Gandin, V
- Masvidal, L
- Cargnello, M
- Gyenis, L
- McLaughlan, S
- Cai, YT
- show more...
- Tenkerian, C
- Morita, M
- Balanathan, P
- Jean-Jean, O
- Stambolic, V
- Trost, M
- Furic, L
- Larose, L
- Koromilas, AE
- Asano, K
- Litchfield, D
- Larsson, O
- Topisirovic, I
- show less...
- Articles in the publication
- Nature communica ...
- By the university
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
