Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition

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Fältnamn	Indikatorer	Metadata
000		04725naa a2200829 4500
001		oai:lup.lub.lu.se:cd696f35-4258-4cb4-a0e2-3f22310c85e5
003		SwePub
008		160401s2006 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/6819162 URI
024	7	a https://doi.org/10.1158/1055-9965.EPI-06-00722 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Agudo, Antonio4 aut
245	1 0	a Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition
264	1	c 2006
520		a Metabolizing enzymes, which often display genetic polymorphisms, are involved in the activation of compounds present in tobacco smoke that may be relevant to gastric carcinogenesis. We report the results of a study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1. A nested case-control study was carried out within the European Prospective Investigation into Cancer and Nutrition, developed in 10 European countries. The study includes 243 newly diagnosed cases of histologically confirmed gastric adenocarcinoma and 946 controls matched by center, age, sex, and date of blood collection. Genotypes were determined in nuclear DNA from WBCs. We found an increased risk of gastric cancer for homozygotes for C (histidine) variant in Y113H of EPHX1 (odds ratio, 1.91; 95% confidence interval, 1.19-3.07) compared with subjects with TC/TT. There was also a significant increased risk for smokers carrying at least one variant allele A in Ex7+129C > A (m4) of CYP1A1 and never smokers with null GSTT1 and allele A in the locus -3859G > A of CYP1A2. Most of these genes are involved in the activation and detoxification of polycyclic aromatic hydrocarbons, suggesting a potential role of these compounds in gastric carcinogenesis.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Sala, Nuria4 aut
700	1	a Pera, Guillem4 aut
700	1	a Capella, Gabriel4 aut
700	1	a Berenguer, Antonio4 aut
700	1	a Garcia, Nadia4 aut
700	1	a Palli, Domenico4 aut
700	1	a Boeing, Heiner4 aut
700	1	a Del Giudice, Giuseppe4 aut
700	1	a Saieva, Calogero4 aut
700	1	a Carneiro, Fatima4 aut
700	1	a Berrino, Franco4 aut
700	1	a Sacerdote, Carlotta4 aut
700	1	a Tumino, Rosario4 aut
700	1	a Panico, Salvatore4 aut
700	1	a Berglund, Göranu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-gbe
700	1	a Simán, Henriku Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)mikr-hsi
700	1	a Stenling, Roger4 aut
700	1	a Hallmans, Goran4 aut
700	1	a Martinez, Carmen4 aut
700	1	a Bilbao, Roberto4 aut
700	1	a Barricarte, Aurelio4 aut
700	1	a Navarro, Carmen4 aut
700	1	a Quiros, Jose R.4 aut
700	1	a Allen, Naomi4 aut
700	1	a Key, Tim4 aut
700	1	a Bingham, Sheila4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Linseisen, Jakob4 aut
700	1	a Nagel, Gabriele4 aut
700	1	a Overvad, Kim4 aut
700	1	a Tjonneland, Anne4 aut
700	1	a Olsen, Anja4 aut
700	1	a Bueno-de-Mesquita, H. Bas4 aut
700	1	a Boshuizen, Hendriek C.4 aut
700	1	a Peeters, Petra H.4 aut
700	1	a Numans, Mattijs E.4 aut
700	1	a Clavel-Chapelon, Francoise4 aut
700	1	a Boutron-Ruault, Marie-Christine4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Lund, Eiliv4 aut
700	1	a Offerhaus, Johan4 aut
700	1	a Jenab, Mazda4 aut
700	1	a Ferrari, Pietro4 aut
700	1	a Norat, Teresa4 aut
700	1	a Riboli, Elio4 aut
700	1	a Gonzalez, Carlos A.4 aut
710	2	a Internmedicin - epidemiologib Forskargrupper vid Lunds universitet4 org
773	0	t Cancer Epidemiology Biomarkers & Preventiong 15:12, s. 2427-2434q 15:12<2427-2434x 1538-7755
856	4	u http://dx.doi.org/10.1158/1055-9965.EPI-06-0072x freey FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/681916
856	4 8	u https://doi.org/10.1158/1055-9965.EPI-06-0072

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Av författaren/redakt...: Agudo, Antonio; Sala, Nuria; Pera, Guillem; Capella, Gabriel; Berenguer, Anton ...; Garcia, Nadia; visa fler...; Palli, Domenico; Boeing, Heiner; Del Giudice, Giu ...; Saieva, Calogero; Carneiro, Fatima; Berrino, Franco; Sacerdote, Carlo ...; Tumino, Rosario; Panico, Salvator ...; Berglund, Göran; Simán, Henrik; Stenling, Roger; Hallmans, Goran; Martinez, Carmen; Bilbao, Roberto; Barricarte, Aure ...; Navarro, Carmen; Quiros, Jose R.; Allen, Naomi; Key, Tim; Bingham, Sheila; Khaw, Kay-Tee; Linseisen, Jakob; Nagel, Gabriele; Overvad, Kim; Tjonneland, Anne; Olsen, Anja; Bueno-de-Mesquit ...; Boshuizen, Hendr ...; Peeters, Petra H ...; Numans, Mattijs ...; Clavel-Chapelon, ...; Boutron-Ruault, ...; Trichopoulou, An ...; Lund, Eiliv; Offerhaus, Johan; Jenab, Mazda; Ferrari, Pietro; Norat, Teresa; Riboli, Elio; Gonzalez, Carlos ...; visa färre...

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Av lärosätet: Lunds universitet

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