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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004167naa a2200409 4500
001oai:lup.lub.lu.se:9e77d100-ffa9-4ff5-960a-8a24c2a7f702
003SwePub
008160401s2006 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:1940121
0247 a https://lup.lub.lu.se/record/4058302 URI
0247 a https://doi.org/10.1186/1477-7827-4-242 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19401212 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Cluff, AH4 aut
2451 0a Prolonged labour associated with lower expression of syndecan 3 and connexin 43 in human uterine tissue
264 c 2006-05-04
264 1b Springer Science and Business Media LLC,c 2006
520 a Background: Prolonged labour is associated with greater morbidity and mortality for mother and child. Connexin 43 is a major myometrial gap junction protein found in human myometrium. Syndecan 3 seems to prevail in the human uterus among heparan sulphate proteoglycans, showing the most significant increase during labour. The aims of the present study were to investigate syndecan 3 and connexin 43 mRNA expressions and protein distributions in human uterine tissue during normal and prolonged labour. Methods: Uterine isthmic biopsies were collected from non-pregnant (n = 7), term pregnant women not in labour (n = 14), in normal labour (n = 7) and in prolonged labour (n = 7). mRNA levels of syndecan 3 and connexin 43 were determined by real time RT-PCR. The localization and expression were demonstrated by immunohistochemistry and confocal microscopy. Results: In women with prolonged labour, the mRNA expressions of syndecan 3 and Connexin 43 were considerably lower than the expression level at normal labour (p < 0.05). In term-pregnant tissue, the expression of syndecan 3 and connexin 43 did not differ significantly compared to nonpregnant and normal labour. The immunoreactivity of syndecan 3 was strong at normal labour, in contrast to prolonged labour, where both a weaker expression and an irregular distribution were detected. The immunoreactivity of connexin 43 increased until term and further stronger staining occurred at normal labour. At prolonged labour, the immunoreactivity was weaker and more unevenly distributed. At labour, a co-localization of syndecan 3 and connexin 43 could be demonstrated in the smooth muscle by confocal microscopy. Conclusion: The high expression of syndecan 3 and connexin 43 and their co-localization to the smooth muscle bundles during normal labour, together with the significant reduction in prolonged labour, may indicate a role for these proteins in the co-ordination of myometrial contractility.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
7001 a Bystrom, Bu Karolinska Institutet4 aut
7001 a Klimaviciute, Au Karolinska Institutet4 aut
7001 a Dahlqvist, Camillau Lund University,Lunds universitet,Matrixbiologi,Forskargrupper vid Lunds universitet,Matrix Biology,Lund University Research Groups4 aut0 (Swepub:lu)medk-cda
7001 a Cebers, G4 aut
7001 a Malmström, Andersu Lund University,Lunds universitet,Matrixbiologi,Forskargrupper vid Lunds universitet,Matrix Biology,Lund University Research Groups4 aut0 (Swepub:lu)medk-ama
7001 a Ekman-Ordeberg, Gu Karolinska Institutet4 aut
7102 a Karolinska Institutetb Matrixbiologi4 org
7730 t Reproductive Biology and Endocrinologyd : Springer Science and Business Media LLCg 4q 4x 1477-7827
8564 u http://dx.doi.org/10.1186/1477-7827-4-24x freey FULLTEXT
8564 u https://rbej.biomedcentral.com/track/pdf/10.1186/1477-7827-4-24
8564 8u https://lup.lub.lu.se/record/405830
8564 8u https://doi.org/10.1186/1477-7827-4-24
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1940121

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