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Epigenome-wide gene...
Epigenome-wide gene-age interaction analysis reveals reversed effects of PRODH DNA methylation on survival between young and elderly early-stage NSCLC patients
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- Chen, Chao (author)
- Nanjing Medical University
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- Wei, Yongyue (author)
- Harvard University,Nanjing Medical University
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- Wei, Liangmin (author)
- Nanjing Medical University
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show more...
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- Chen, Jiajin (author)
- Nanjing Medical University
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- Chen, Xin (author)
- Nanjing Medical University
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- Dong, Xuesi (author)
- Nanjing Medical University,Southeast University
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- He, Jieyu (author)
- Nanjing Medical University
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- Lin, Lijuan (author)
- Nanjing Medical University,Harvard University
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- Zhu, Ying (author)
- Nanjing Medical University
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- Huang, Hui (author)
- Nanjing Medical University
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- You, Dongfang (author)
- Harvard University,Nanjing Medical University
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- Lai, Linjing (author)
- Nanjing Medical University
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- Shen, Sipeng (author)
- Nanjing Medical University,Harvard University
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- Duan, Weiwei (author)
- Nanjing Medical University
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- Su, Li (author)
- Harvard University,Nanjing Medical University
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- Shafer, Andrea (author)
- Massachusetts General Hospital,Harvard University
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- Fleischer, Thomas (author)
- Oslo university hospital
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- Bjaanæs, Maria Moksnes (author)
- Oslo university hospital
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- Karlsson, Anna (author)
- Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Planck, Maria (author)
- Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Wang, Rui (author)
- Jinling Hospital, Nanjing,Nanjing University
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- Staaf, Johan (author)
- Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Helland, Åslaug (author)
- University of Oslo,Oslo university hospital
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- Esteller, Manel (author)
- Spanish Center for Biomedical Research Network in Oncology (CIBERONC),Catalan Institution for Research and Advanced Studies,University of Barcelona,Josep Carreras Leukaemia Research Institute (IJC)
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- Zhang, Ruyang (author)
- Jinling Hospital, Nanjing,Nanjing University,Nanjing Medical University
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- Chen, Feng (author)
- Nanjing Medical University
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- Christiani, David C. (author)
- Harvard University,Massachusetts General Hospital
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(creator_code:org_t)
- 2020-06-08
- 2020
- English 21 s.
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In: Aging. - : Impact Journals, LLC. - 1945-4589. ; 12:11, s. 10642-10662
- Related links:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- DNA methylation changes during aging, but it remains unclear whether the effect of DNA methylation on lung cancer survival varies with age. Such an effect could decrease prediction accuracy and treatment efficacy. We performed a methylation-age interaction analysis using 1,230 early-stage lung adenocarcinoma patients from five cohorts. A Cox proportional hazards model was used to investigate lung adenocarcinoma and squamous cell carcinoma patients for methylation-age interactions, which were further confirmed in a validation phase. We identified one adenocarcinoma-specific CpG probe, cg14326354PRODH, with effects significantly modified by age (HRinteraction = 0.989; 95% CI: 0.986-0.994; P = 9.18×10-7). The effect of low methylation was reversed for young and elderly patients categorized by the boundary of 95% CI standard (HRyoung = 2.44; 95% CI: 1.26-4.72; P = 8.34×10-3; HRelderly = 0.58; 95% CI: 0.42-0.82; P = 1.67×10-3). Moreover, there was an antagonistic interaction between low cg14326354PRODH methylation and elderly age (HRinteraction = 0.21; 95% CI: 0.11-0.40; P = 2.20×10-6). In summary, low methylation of cg14326354PRODH might benefit survival of elderly lung adenocarcinoma patients, providing new insight to age-specific prediction and potential drug targeting.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Aging
- DNA methylation
- Methylation-age interaction analysis
- Non-small cell lung cancer
- Overall survival
Publication and Content Type
- art (subject category)
- ref (subject category)
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Aging
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To the university's database
- By the author/editor
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Chen, Chao
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Wei, Yongyue
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Wei, Liangmin
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Chen, Jiajin
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Chen, Xin
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Dong, Xuesi
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show more...
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He, Jieyu
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Lin, Lijuan
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Zhu, Ying
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Huang, Hui
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You, Dongfang
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Lai, Linjing
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Shen, Sipeng
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Duan, Weiwei
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Su, Li
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Shafer, Andrea
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Fleischer, Thoma ...
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Bjaanæs, Maria M ...
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Karlsson, Anna
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Planck, Maria
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Wang, Rui
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Staaf, Johan
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Helland, Åslaug
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Esteller, Manel
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Zhang, Ruyang
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Chen, Feng
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Christiani, Davi ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Aging
- By the university
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Lund University