The role of diabetes mellitus in the aetiology of renal cell cancer

Lindblad, Per,1953-Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden (author)

To investigate the relation between diabetes mellitus and the risk of renal cell cancer we carried out a population-based retrospective cohort study. Patients identified in the Swedish Inpatient Register who were discharged from hospitals with a diagnosis of diabetes mellitus between 1965 and 1983 formed a cohort of 153852 patients (80005 women and 73847 men). The cohort members were followed up to 1989 by record linkage to three nation-wide registries. Standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) were computed using age-specific sex-specific and period-specific incidence and mortality rates derived from the entire Swedish population. After exclusion of the first year of observation, a total of 267 incidences of renal cell cancer (ICD-7:180.0) occurred in diabetic patients compared with the 182.4 that had been expected. Increased risks were observed in both women (SIR = 1.7, 95% confidence interval, CI = 1.4-2.0) and men (SIR = 1.3; 95 % CI = 1.1-1.6) throughout the duration of follow-up (1-25 years). A higher risk was seen for kidney cancer (ICD-7:180) mortality (SMR = 1.9; 95% CI = 1.7-2.2, women; SMR 1.7, 95% CI = 1.4-1.9, men). In comparison with the general population, patients with diabetes mellitus have an increased risk of renal cell cancer.

Chow, W. H.National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland, USA (author)
Chan, J.Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA (author)
Bergström, A.Karolinska Institutet (author)
Wolk, A.Karolinska Institutet (author)
Gridley, G.National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland, USA (author)
McLaughlin, J. K.International Epidemiology Institute, Rockville, Maryland, USA (author)
Nyren, O.Karolinska Institutet (author)
Adami, H. O.Karolinska Institutet (author)
Department of Medical Epidemiology, Karolinska Institute, Stockholm, SwedenNational Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland, USA (creator_code:org_t)

By the author/editor: Lindblad, Per, 1 ...; Chow, W. H.; Chan, J.; Bergström, A.; Wolk, A.; Gridley, G.; show more...; McLaughlin, J. K ...; Nyren, O.; Adami, H. O.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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