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  • Arango, CelsoHosp Gen Univ Gregorio Maranon, Spain; Univ Complutense Madrid, Spain; Biomed Res Ctr Mental Hlth CIBERSAM, Spain (författare)

Risk and protective factors for mental disorders beyond genetics: an evidence-based atlas

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-09-09
  • John Wiley & Sons,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-179834
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-179834URI
  • https://doi.org/10.1002/wps.20894DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Decades of research have revealed numerous risk factors for mental disorders beyond genetics, but their consistency and magnitude remain uncer-tain. We conducted a "meta-umbrella" systematic synthesis of umbrella reviews, which are systematic reviews of meta-analyses of individual studies, by searching international databases from inception to January 1, 2021. We included umbrella reviews on non-purely genetic risk or protective factors for any ICD/DSM mental disorders, applying an established classification of the credibility of the evidence: class I (convincing), class II (highly suggestive), class III (suggestive), class IV (weak). Sensitivity analyses were conducted on prospective studies to test for temporality (reverse causation), TRANSD criteria were applied to test transdiagnosticity of factors, and A Measurement Tool to Assess Systematic Reviews (AMSTAR) was employed to address the quality of meta-analyses. Fourteen eligible umbrella reviews were retrieved, summarizing 390 meta-analyses and 1,180 associations between putative risk or protective factors and mental disorders. We included 176 class I to III evidence associations, relating to 142 risk/protective factors. The most robust risk factors (class I or II, from prospective designs) were 21. For dementia, they included type 2 diabetes mellitus (risk ratio, RR from 1.54 to 2.28), depression (RR from 1.65 to 1.99) and low frequency of social contacts (RR=1.57). For opioid use disorders, the most robust risk factor was tobacco smoking (odds ratio, OR=3.07). For non-organic psychotic disorders, the most robust risk factors were clinical high risk state for psychosis (OR=9.32), cannabis use (OR=3.90), and childhood adversities (OR=2.80). For depressive disorders, they were widowhood (RR=5.59), sexual dysfunction (OR=2.71), three (OR=1.99) or four-five (OR=2.06) metabolic factors, childhood physical (OR=1.98) and sexual (OR=2.42) abuse, job strain (OR=1.77), obesity (OR=1.35), and sleep disturbances (RR=1.92). For autism spectrum disorder, the most robust risk factor was maternal overweight pre/during pregnancy (RR=1.28). For attention-deficit/hyperactivity disorder (ADHD), they were maternal pre-pregnancy obesity (OR=1.63), maternal smoking during pregnancy (OR=1.60), and maternal overweight pre/during pregnancy (OR=1.28). Only one robust protective factor was detected: high physical activity (hazard ratio, HR=0.62) for Alzheimers disease. In all, 32.9% of the associations were of high quality, 48.9% of medium quality, and 18.2% of low quality. Transdiagnostic class I-III risk/protective factors were mostly involved in the early neurodevelopmental period. The evidence-based atlas of key risk and protective factors identified in this study represents a benchmark for advancing clinical characterization and research, and for expanding early intervention and preventive strategies for mental disorders.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Dragioti, ElenaLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum(Swepub:liu)eledr71 (författare)
  • Solmi, MarcoKings Coll London, England; Univ Padua, Italy; Univ Ottawa, Canada; Ottawa Hosp, Canada (författare)
  • Cortese, SamueleUniv Southampton, England; Univ Southampton, England; Univ Nottingham, England; NYU Langone, NY USA (författare)
  • Domschke, KatharinaUniv Freiburg, Germany; Univ Freiburg, Germany; Univ Freiburg, Germany (författare)
  • Murray, Robin M.Kings Coll London, England (författare)
  • Jones, Peter B.Univ Cambridge, England; Cambridgeshire & Peterborough Natl Hlth Serv Fdn, England (författare)
  • Uher, RudolfDalhousie Univ, Canada; Nova Scotia Hlth, Canada; IWK Hlth Ctr, Canada; Dalhousie Univ, Canada (författare)
  • Carvalho, Andre F.Deakin Univ, Australia; Univ Toronto, Canada; Ctr Addict & Mental Hlth, Canada (författare)
  • Reichenberg, AbrahamIcahn Sch Med Mt Sinai, NY 10029 USA; Icahn Sch Med Mt Sinai, NY 10029 USA; Icahn Sch Med Mt Sinai, NY 10029 USA (författare)
  • Shin, Jae IiYonsei Univ, South Korea; Severance Childrens Hosp, South Korea (författare)
  • Andreassen, Ole A.Univ Oslo, Norway; Oslo Univ Hosp, Norway (författare)
  • Correll, Christoph U.Northwell Hlth, NY USA; Zucker Sch Med Hofstra Northwell, NY USA; Feinstein Inst Med Res, NY USA; Charite, Germany (författare)
  • Fusar-Poli, PaoloKings Coll London, England; South London & Maudsley NHS Fdn Trust, England; Univ Pavia, Italy (författare)
  • Hosp Gen Univ Gregorio Maranon, Spain; Univ Complutense Madrid, Spain; Biomed Res Ctr Mental Hlth CIBERSAM, SpainAvdelningen för prevention, rehabilitering och nära vård (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:World Psychiatry: John Wiley & Sons20:3, s. 417-4361723-86172051-5545

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