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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006434naa a2200481 4500
001oai:DiVA.org:liu-179834
003SwePub
008211005s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1798342 URI
0247 a https://doi.org/10.1002/wps.208942 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Arango, Celsou Hosp Gen Univ Gregorio Maranon, Spain; Univ Complutense Madrid, Spain; Biomed Res Ctr Mental Hlth CIBERSAM, Spain4 aut
2451 0a Risk and protective factors for mental disorders beyond genetics: an evidence-based atlas
264 c 2021-09-09
264 1b John Wiley & Sons,c 2021
338 a electronic2 rdacarrier
520 a Decades of research have revealed numerous risk factors for mental disorders beyond genetics, but their consistency and magnitude remain uncer-tain. We conducted a "meta-umbrella" systematic synthesis of umbrella reviews, which are systematic reviews of meta-analyses of individual studies, by searching international databases from inception to January 1, 2021. We included umbrella reviews on non-purely genetic risk or protective factors for any ICD/DSM mental disorders, applying an established classification of the credibility of the evidence: class I (convincing), class II (highly suggestive), class III (suggestive), class IV (weak). Sensitivity analyses were conducted on prospective studies to test for temporality (reverse causation), TRANSD criteria were applied to test transdiagnosticity of factors, and A Measurement Tool to Assess Systematic Reviews (AMSTAR) was employed to address the quality of meta-analyses. Fourteen eligible umbrella reviews were retrieved, summarizing 390 meta-analyses and 1,180 associations between putative risk or protective factors and mental disorders. We included 176 class I to III evidence associations, relating to 142 risk/protective factors. The most robust risk factors (class I or II, from prospective designs) were 21. For dementia, they included type 2 diabetes mellitus (risk ratio, RR from 1.54 to 2.28), depression (RR from 1.65 to 1.99) and low frequency of social contacts (RR=1.57). For opioid use disorders, the most robust risk factor was tobacco smoking (odds ratio, OR=3.07). For non-organic psychotic disorders, the most robust risk factors were clinical high risk state for psychosis (OR=9.32), cannabis use (OR=3.90), and childhood adversities (OR=2.80). For depressive disorders, they were widowhood (RR=5.59), sexual dysfunction (OR=2.71), three (OR=1.99) or four-five (OR=2.06) metabolic factors, childhood physical (OR=1.98) and sexual (OR=2.42) abuse, job strain (OR=1.77), obesity (OR=1.35), and sleep disturbances (RR=1.92). For autism spectrum disorder, the most robust risk factor was maternal overweight pre/during pregnancy (RR=1.28). For attention-deficit/hyperactivity disorder (ADHD), they were maternal pre-pregnancy obesity (OR=1.63), maternal smoking during pregnancy (OR=1.60), and maternal overweight pre/during pregnancy (OR=1.28). Only one robust protective factor was detected: high physical activity (hazard ratio, HR=0.62) for Alzheimers disease. In all, 32.9% of the associations were of high quality, 48.9% of medium quality, and 18.2% of low quality. Transdiagnostic class I-III risk/protective factors were mostly involved in the early neurodevelopmental period. The evidence-based atlas of key risk and protective factors identified in this study represents a benchmark for advancing clinical characterization and research, and for expanding early intervention and preventive strategies for mental disorders.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
653 a Risk factors; protective factors; mental disorders; dementia; psychotic disorders; mood disorders; autism spectrum disorder; attention-deficit; hyperactivity disorder; early intervention; preventive strategies
7001 a Dragioti, Elenau Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum4 aut0 (Swepub:liu)eledr71
7001 a Solmi, Marcou Kings Coll London, England; Univ Padua, Italy; Univ Ottawa, Canada; Ottawa Hosp, Canada4 aut
7001 a Cortese, Samueleu Univ Southampton, England; Univ Southampton, England; Univ Nottingham, England; NYU Langone, NY USA4 aut
7001 a Domschke, Katharinau Univ Freiburg, Germany; Univ Freiburg, Germany; Univ Freiburg, Germany4 aut
7001 a Murray, Robin M.u Kings Coll London, England4 aut
7001 a Jones, Peter B.u Univ Cambridge, England; Cambridgeshire & Peterborough Natl Hlth Serv Fdn, England4 aut
7001 a Uher, Rudolfu Dalhousie Univ, Canada; Nova Scotia Hlth, Canada; IWK Hlth Ctr, Canada; Dalhousie Univ, Canada4 aut
7001 a Carvalho, Andre F.u Deakin Univ, Australia; Univ Toronto, Canada; Ctr Addict & Mental Hlth, Canada4 aut
7001 a Reichenberg, Abrahamu Icahn Sch Med Mt Sinai, NY 10029 USA; Icahn Sch Med Mt Sinai, NY 10029 USA; Icahn Sch Med Mt Sinai, NY 10029 USA4 aut
7001 a Shin, Jae Iiu Yonsei Univ, South Korea; Severance Childrens Hosp, South Korea4 aut
7001 a Andreassen, Ole A.u Univ Oslo, Norway; Oslo Univ Hosp, Norway4 aut
7001 a Correll, Christoph U.u Northwell Hlth, NY USA; Zucker Sch Med Hofstra Northwell, NY USA; Feinstein Inst Med Res, NY USA; Charite, Germany4 aut
7001 a Fusar-Poli, Paolou Kings Coll London, England; South London & Maudsley NHS Fdn Trust, England; Univ Pavia, Italy4 aut
7102 a Hosp Gen Univ Gregorio Maranon, Spain; Univ Complutense Madrid, Spain; Biomed Res Ctr Mental Hlth CIBERSAM, Spainb Avdelningen för prevention, rehabilitering och nära vård4 org
7730 t World Psychiatryd : John Wiley & Sonsg 20:3, s. 417-436q 20:3<417-436x 1723-8617x 2051-5545
8564 u https://liu.diva-portal.org/smash/get/diva2:1600481/FULLTEXT01.pdfx primaryx Raw objecty fulltext:postprint
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/wps.20894
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-179834
8564 8u https://doi.org/10.1002/wps.20894

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