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Robust humoral and ...
Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19
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- Havervall, Sebastian (author)
- Karolinska Institutet
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- Ng, Henry (author)
- Uppsala universitet,Integrativ Fysiologi,Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden
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- Jernbom Falk, August (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden
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- Greilert-Norin, Nina (author)
- Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden
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- Månberg, Anna, 1985- (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden
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- Marking, Ulrika (author)
- Karolinska Institutet
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- Laurén, Ida (author)
- Uppsala universitet,Institutionen för farmaci
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- Gabrielsson, Lena (author)
- Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden
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- Salomonsson, Ann-Christin (author)
- Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden
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- Aguilera, Katherina (author)
- Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden
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- Kihlgren, Martha (author)
- Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden
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- Månsson, Maja (author)
- Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden
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- Rosell, Axel (author)
- Karolinska Institutet
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- Hellström, Cecilia (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden
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- Andersson, Eni (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden
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- Olofsson, Jennie (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden
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- Skoglund, Lovisa (author)
- Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden
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- Yousef, Jamil (author)
- Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden
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- Pin, Elisa (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden
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- Lord, Martin (author)
- Uppsala universitet,Institutionen för farmaci
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- Åberg, Mikael (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk kemi
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- Hedhammar, My, Professor, 1975- (author)
- KTH,Proteinteknologi,Science for Life Laboratory, SciLifeLab,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden
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- Tegel, Hanna (author)
- KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden
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- Dönnes, Pierre (author)
- SciCross AB, Skövde, Sweden
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- Phillipson, Mia, 1973- (author)
- Uppsala universitet,Integrativ Fysiologi
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- Nilsson, Peter (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden
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- Klingström, Jonas (author)
- Karolinska Institutet
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- Mangsbo, Sara, 1981- (author)
- Uppsala universitet,Institutionen för farmaci
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- Hober, Sophia, Professor, 1965- (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinteknologi,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden
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- Thålin, Charlotte (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-09-27
- 2022
- English.
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In: Journal of Internal Medicine. - : John Wiley & Sons. - 0954-6820 .- 1365-2796. ; 291:1, s. 72-80
- Related links:
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https://doi.org/10.1...
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Emerging data support detectable immune responses for months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination, but it is not yet established to what degree and for how long protection against reinfection lasts.Methods: We investigated SARS-CoV-2-specific humoral and cellular immune responses more than 8 months post-asymptomatic, mild and severe infection in a cohort of 1884 healthcare workers (HCW) and 51 hospitalized COVID-19 patients. Possible protection against SARS-CoV-2 reinfection was analyzed by a weekly 3-month polymerase chain reaction (PCR) screening of 252 HCW that had seroconverted 7 months prior to start of screening and 48 HCW that had remained seronegative at multiple time points.Results: All COVID-19 patients and 96% (355/370) of HCW who were anti-spike IgG positive at inclusion remained anti-spike IgG positive at the 8-month follow-up. Circulating SARS-CoV-2-specific memory T cell responses were detected in 88% (45/51) of COVID-19 patients and in 63% (233/370) of seropositive HCW. The cumulative incidence of PCR-confirmed SARS-CoV-2 infection was 1% (3/252) among anti-spike IgG positive HCW (0.13 cases per 100 weeks at risk) compared to 23% (11/48) among anti-spike IgG negative HCW (2.78 cases per 100 weeks at risk), resulting in a protective effect of 95.2% (95% CI 81.9%-99.1%).Conclusions: The vast majority of anti-spike IgG positive individuals remain anti-spike IgG positive for at least 8 months regardless of initial COVID-19 disease severity. The presence of anti-spike IgG antibodies is associated with a substantially reduced risk of reinfection up to 9 months following asymptomatic to mild COVID-19.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- COVID-19
- SARS-CoV-2
- humoral response
- long-term immunity
- reinfection
- Biotechnology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Havervall, Sebas ...
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Ng, Henry
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Jernbom Falk, Au ...
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Greilert-Norin, ...
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Månberg, Anna, 1 ...
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Marking, Ulrika
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Laurén, Ida
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Gabrielsson, Len ...
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Salomonsson, Ann ...
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Aguilera, Kather ...
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Kihlgren, Martha
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Månsson, Maja
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Rosell, Axel
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Hellström, Cecil ...
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Andersson, Eni
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Olofsson, Jennie
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Skoglund, Lovisa
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Yousef, Jamil
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Pin, Elisa
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Lord, Martin
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Åberg, Mikael
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Hedhammar, My, P ...
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Tegel, Hanna
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Dönnes, Pierre
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Phillipson, Mia, ...
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Nilsson, Peter
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Klingström, Jona ...
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Mangsbo, Sara, 1 ...
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Hober, Sophia, P ...
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Thålin, Charlott ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Journal of Inter ...
- By the university
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Uppsala University
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Royal Institute of Technology
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Karolinska Institutet