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Sökning: WFRF:(De Caterina Raffaele) > (2015-2019) > Digoxin and Mortali...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005465naa a2200517 4500
001oai:DiVA.org:uu-350280
003SwePub
008180509s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3502802 URI
0247 a https://doi.org/10.1016/j.jacc.2017.12.0602 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lopes, Renato D.u Duke Univ, Sch Med, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA.4 aut
2451 0a Digoxin and Mortality in Patients With Atrial Fibrillation
264 1b ELSEVIER SCIENCE INC,c 2018
338 a print2 rdacarrier
520 a BACKGROUND: Digoxin is widely used in patients with atrial fibrillation (AF). OBJECTIVES The goal of this paper was to explore whether digoxin use was independently associated with increased mortality in patients with AF and if the association was modified by heart failure and/or serum digoxin concentration.METHODS: The association between digoxin use and mortality was assessed in 17,897 patients by using a propensity score-adjusted analysis and in new digoxin users during the trial versus propensity score-matched control participants. The authors investigated the independent association between serum digoxin concentration and mortality after multivariable adjustment.RESULTS: At baseline, 5,824 (32.5%) patients were receiving digoxin. Baseline digoxin use was not associated with an increased risk of death (adjusted hazard ratio [HR]: 1.09; 95% confidence interval [CI]: 0.96 to 1.23; p = 0.19). However, patients with a serum digoxin concentration $ 1.2 ng/ml had a 56% increased hazard of mortality (adjusted HR: 1.56; 95% CI: 1.20 to 2.04) compared with those not on digoxin. When analyzed as a continuous variable, serum digoxin concentration was associated with a 19% higher adjusted hazard of death for each 0.5-ng/ml increase (p = 0.0010); these results were similar for patients with and without heart failure. Compared with propensity score-matched control participants, the risk of death (adjusted HR: 1.78; 95% CI: 1.37 to 2.31) and sudden death (adjusted HR: 2.14; 95% CI: 1.11 to 4.12) was significantly higher in new digoxin users.CONCLUSIONS: In patients with AF taking digoxin, the risk of death was independently related to serum digoxin concentration and was highest in patients with concentrations $ 1.2 ng/ml. Initiating digoxin was independently associated with higher mortality in patients with AF, regardless of heart failure.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a atrial fibrillation
653 a digoxin
653 a heart failure
653 a mortality
7001 a Rordorf, Robertou Fdn IRCCS Policlin San Matteo, Coronary Care Unit, Pavia, Italy.;Fdn IRCCS Policlin San Matteo, Lab Clin & Expt Cardiol, Pavia, Italy.;Univ Pavia, Dept Mol Med, Pavia, Italy.4 aut
7001 a De Ferrari, Gaetano M.u Fdn IRCCS Policlin San Matteo, Coronary Care Unit, Pavia, Italy.;Fdn IRCCS Policlin San Matteo, Lab Clin & Expt Cardiol, Pavia, Italy.;Univ Pavia, Dept Mol Med, Pavia, Italy.4 aut
7001 a Leonardi, Sergiou Fdn IRCCS Policlin San Matteo, Coronary Care Unit, Pavia, Italy.;Fdn IRCCS Policlin San Matteo, Lab Clin & Expt Cardiol, Pavia, Italy.;Univ Pavia, Dept Mol Med, Pavia, Italy.4 aut
7001 a Thomas, Laineu Duke Univ, Sch Med, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA.4 aut
7001 a Wojdyla, Daniel M.u Duke Univ, Sch Med, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA.4 aut
7001 a Ridefelt, Peteru Uppsala universitet,Klinisk kemi4 aut0 (Swepub:uu)peteride
7001 a Lawrence, John H.u Bristol Myers Squibb Co, Princeton, NJ USA.4 aut
7001 a De Caterina, Raffaeleu Univ G dAnnunzio, Inst Cardiol, Chieti, Italy.4 aut
7001 a Vinereanu, Dragosu Univ & Emergency Hosp, Univ Med & Pharm Carol Davila, Bucharest, Romania.4 aut
7001 a Hanna, Michaelu Univ G dAnnunzio, Inst Cardiol, Chieti, Italy.4 aut
7001 a Flaker, Gregu Univ Missouri, Columbia, MO USA.4 aut
7001 a Al-Khatib, Sana M.u Duke Univ, Sch Med, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA.4 aut
7001 a Hohnloser, Stefan H.u Goethe Univ Frankfurt, Frankfurt, Germany.4 aut
7001 a Alexander, John H.u Duke Univ, Sch Med, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA.4 aut
7001 a Granger, Christopher B.u Duke Univ, Sch Med, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA.4 aut
7001 a Wallentin, Lars,d 1943-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)larswall
7102 a Duke Univ, Sch Med, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA.b Fdn IRCCS Policlin San Matteo, Coronary Care Unit, Pavia, Italy.;Fdn IRCCS Policlin San Matteo, Lab Clin & Expt Cardiol, Pavia, Italy.;Univ Pavia, Dept Mol Med, Pavia, Italy.4 org
7730 t Journal of the American College of Cardiologyd : ELSEVIER SCIENCE INCg 71:10, s. 1063-1074q 71:10<1063-1074x 0735-1097x 1558-3597
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-350280
8564 8u https://doi.org/10.1016/j.jacc.2017.12.060

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