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Sökning: WFRF:(Di Paolo Gilbert) > (2012) > Bezafibrate adminis...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003645naa a2200457 4500
001oai:lup.lub.lu.se:95c1bff4-3efe-4447-99e3-1440324f41fc
003SwePub
008160401s2012 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/33794512 URI
0247 a https://doi.org/10.1093/hmg/dds3552 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Dumont, Magali4 aut
2451 0a Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice
264 c 2012-08-24
264 1b Oxford University Press (OUP),c 2012
520 a Peroxisome proliferator-activated receptors (PPARs) are ligand-mediated transcription factors, which control both lipid and energy metabolism and inflammation pathways. PPAR agonists are effective in the treatment of metabolic diseases and, more recently, neurodegenerative diseases, in which they show promising neuroprotective effects. We studied the effects of the pan-PPAR agonist bezafibrate on tau pathology, inflammation, lipid metabolism and behavior in transgenic mice with the P301S human tau mutation, which causes familial frontotemporal lobar degeneration. Bezafibrate treatment significantly decreased tau hyperphosphorylation using AT8 staining and the number of MC1-positive neurons. Bezafibrate treatment also diminished microglial activation and expression of both inducible nitric oxide synthase and cyclooxygenase 2. Additionally, the drug differentially affected the brain and brown fat lipidome of control and P301S mice, preventing lipid vacuoles in brown fat. These effects were associated with behavioral improvement, as evidenced by reduced hyperactivity and disinhibition in the P301S mice. Bezafibrate therefore exerts neuroprotective effects in a mouse model of tauopathy, as shown by decreased tau pathology and behavioral improvement. Since bezafibrate was given to the mice before tau pathology had developed, our data suggest that bezafibrate exerts a preventive effect on both tau pathology and its behavioral consequences. Bezafibrate is therefore a promising agent for the treatment of neurodegenerative diseases associated with tau pathology.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
7001 a Stack, Cliona4 aut
7001 a Elipenahli, Ceyhan4 aut
7001 a Jainuddin, Shari4 aut
7001 a Gerges, Meri4 aut
7001 a Starkova, Natalia4 aut
7001 a Calingasan, Noel Y.4 aut
7001 a Yang, Lichuan4 aut
7001 a Tampellini, Davideu Lund University,Lunds universitet,Experimentell demensforskning,Forskargrupper vid Lunds universitet,Experimental Dementia Research,Lund University Research Groups4 aut0 (Swepub:lu)med-dvt
7001 a Starkov, Anatoly A.4 aut
7001 a Chan, Robin B.4 aut
7001 a Di Paolo, Gilbert4 aut
7001 a Pujol, Aurora4 aut
7001 a Beal, M. Flint4 aut
7102 a Experimentell demensforskningb Forskargrupper vid Lunds universitet4 org
7730 t Human Molecular Geneticsd : Oxford University Press (OUP)g 21:23, s. 5091-5105q 21:23<5091-5105x 0964-6906x 1460-2083
8564 u http://dx.doi.org/10.1093/hmg/dds355y FULLTEXT
8564 u https://academic.oup.com/hmg/article-pdf/21/23/5091/17257363/dds355.pdf
8564 8u https://lup.lub.lu.se/record/3379451
8564 8u https://doi.org/10.1093/hmg/dds355

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