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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 12510naa a2203277 4500 | |
| 001 | oai:DiVA.org:umu-111999 | |
| 003 | SwePub | |
| 008 | 151130s2015 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:394f2772-061c-4358-a79c-69b1adf24c52 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1119992 URI |
| 024 | 7 | a https://doi.org/10.1038/ng.34052 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/80355212 URI |
| 040 | a (SwePub)umud (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kato, Norihiro4 aut |
| 245 | 1 0 | a Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation |
| 264 | c 2015-09-21 | |
| 264 | 1 | b Nature Publishing Group,c 2015 |
| 338 | a print2 rdacarrier | |
| 520 | a We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10−11 to 5.0 × 10−21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10−6). Our results provide new evidence for the role of DNA methylation in blood pressure regulation. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 700 | 1 | a Loh, Marie4 aut |
| 700 | 1 | a Takeuchi, Fumihiko4 aut |
| 700 | 1 | a Verweij, Niek4 aut |
| 700 | 1 | a Wang, Xu4 aut |
| 700 | 1 | a Zhang, Weihua4 aut |
| 700 | 1 | a Kelly, Tanika N.4 aut |
| 700 | 1 | a Saleheen, Danish4 aut |
| 700 | 1 | a Lehne, Benjamin4 aut |
| 700 | 1 | a Leach, Irene Mateo4 aut |
| 700 | 1 | a Drong, Alexander W.4 aut |
| 700 | 1 | a Abbott, James4 aut |
| 700 | 1 | a Wahl, Simone4 aut |
| 700 | 1 | a Tan, Sian-Tsung4 aut |
| 700 | 1 | a Scott, William R.4 aut |
| 700 | 1 | a Campanella, Gianluca4 aut |
| 700 | 1 | a Chadeau-Hyam, Marc4 aut |
| 700 | 1 | a Afzal, Uzma4 aut |
| 700 | 1 | a Ahluwalia, Tarunveer S.4 aut |
| 700 | 1 | a Bonder, Marc Jan4 aut |
| 700 | 1 | a Chen, Peng4 aut |
| 700 | 1 | a Dehghan, Abbas4 aut |
| 700 | 1 | a Edwards, Todd L.4 aut |
| 700 | 1 | a Esko, Tonu4 aut |
| 700 | 1 | a Go, Min Jin4 aut |
| 700 | 1 | a Harris, Sarah E.4 aut |
| 700 | 1 | a Hartiala, Jaana4 aut |
| 700 | 1 | a Kasela, Silva4 aut |
| 700 | 1 | a Kasturiratne, Anuradhani4 aut |
| 700 | 1 | a Khor, Chiea-Chuen4 aut |
| 700 | 1 | a Kleber, Marcus E.4 aut |
| 700 | 1 | a Li, Huaixing4 aut |
| 700 | 1 | a Mok, Zuan Yu4 aut |
| 700 | 1 | a Nakatochi, Masahiro4 aut |
| 700 | 1 | a Sapari, Nur Sabrina4 aut |
| 700 | 1 | a Saxena, Richa4 aut |
| 700 | 1 | a Stewart, Alexandre F. R.4 aut |
| 700 | 1 | a Stolk, Lisette4 aut |
| 700 | 1 | a Tabara, Yasuharu4 aut |
| 700 | 1 | a Teh, Ai Ling4 aut |
| 700 | 1 | a Wu, Ying4 aut |
| 700 | 1 | a Wu, Jer-Yuarn4 aut |
| 700 | 1 | a Zhang, Yi4 aut |
| 700 | 1 | a Aits, Imke4 aut |
| 700 | 1 | a Alves, Alexessander Da Silva Couto4 aut |
| 700 | 1 | a Das, Shikta4 aut |
| 700 | 1 | a Dorajoo, Rajkumar4 aut |
| 700 | 1 | a Hopewell, Jemma C.4 aut |
| 700 | 1 | a Kim, Yun Kyoung4 aut |
| 700 | 1 | a Koivula, Robertu Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-rkl |
| 700 | 1 | a Luan, Jian'an4 aut |
| 700 | 1 | a Lyytikainen, Leo-Pekka4 aut |
| 700 | 1 | a Nguyen, Quang N.4 aut |
| 700 | 1 | a Pereira, Mark A.4 aut |
| 700 | 1 | a Postmus, Iris4 aut |
| 700 | 1 | a Raitakari, Olli T.4 aut |
| 700 | 1 | a Bryan, Molly Scannell4 aut |
| 700 | 1 | a Scott, Robert A.4 aut |
| 700 | 1 | a Sorice, Rossella4 aut |
| 700 | 1 | a Tragante, Vinicius4 aut |
| 700 | 1 | a Traglia, Michela4 aut |
| 700 | 1 | a White, Jon4 aut |
| 700 | 1 | a Yamamoto, Ken4 aut |
| 700 | 1 | a Zhang, Yonghong4 aut |
| 700 | 1 | a Adair, Linda S.4 aut |
| 700 | 1 | a Ahmed, Alauddin4 aut |
| 700 | 1 | a Akiyama, Koichi4 aut |
| 700 | 1 | a Asif, Rasheed4 aut |
| 700 | 1 | a Aung, Tin4 aut |
| 700 | 1 | a Barroso, Ines4 aut |
| 700 | 1 | a Bjonnes, Andrew4 aut |
| 700 | 1 | a Braun, Timothy R.4 aut |
| 700 | 1 | a Cai, Hui4 aut |
| 700 | 1 | a Chang, Li-Ching4 aut |
| 700 | 1 | a Chen, Chien-Hsiun4 aut |
| 700 | 1 | a Cheng, Ching-Yu4 aut |
| 700 | 1 | a Chong, Yap-Seng4 aut |
| 700 | 1 | a Collins, Rory4 aut |
| 700 | 1 | a Courtney, Regina4 aut |
| 700 | 1 | a Davies, Gail4 aut |
| 700 | 1 | a Delgado, Graciela4 aut |
| 700 | 1 | a Do, Loi D.4 aut |
| 700 | 1 | a Doevendans, Pieter A.4 aut |
| 700 | 1 | a Gansevoort, Ron T.4 aut |
| 700 | 1 | a Gao, Yu-Tang4 aut |
| 700 | 1 | a Grammer, Tanja B.4 aut |
| 700 | 1 | a Grarup, Niels4 aut |
| 700 | 1 | a Grewal, Jagvir4 aut |
| 700 | 1 | a Gu, Dongfeng4 aut |
| 700 | 1 | a Wander, Gurpreet S.4 aut |
| 700 | 1 | a Hartikainen, Anna-Liisa4 aut |
| 700 | 1 | a Hazen, Stanley L.4 aut |
| 700 | 1 | a He, Jing4 aut |
| 700 | 1 | a Heng, Chew-Kiat4 aut |
| 700 | 1 | a Hixson, James E.4 aut |
| 700 | 1 | a Hofman, Albert4 aut |
| 700 | 1 | a Hsu, Chris4 aut |
| 700 | 1 | a Huang, Wei4 aut |
| 700 | 1 | a Husemoen, Lise L. N.4 aut |
| 700 | 1 | a Hwang, Joo-Yeon4 aut |
| 700 | 1 | a Ichihara, Sahoko4 aut |
| 700 | 1 | a Igase, Michiya4 aut |
| 700 | 1 | a Isono, Masato4 aut |
| 700 | 1 | a Justesen, Johanne M.4 aut |
| 700 | 1 | a Katsuy, Tomohiro4 aut |
| 700 | 1 | a Kibriya, Muhammad G.4 aut |
| 700 | 1 | a Kim, Young Jin4 aut |
| 700 | 1 | a Kishimoto, Miyako4 aut |
| 700 | 1 | a Koh, Woon-Puay4 aut |
| 700 | 1 | a Kohara, Katsuhiko4 aut |
| 700 | 1 | a Kumari, Meena4 aut |
| 700 | 1 | a Kwek, Kenneth4 aut |
| 700 | 1 | a Lee, Nanette R.4 aut |
| 700 | 1 | a Lee, Jeannette4 aut |
| 700 | 1 | a Liao, Jiemin4 aut |
| 700 | 1 | a Lieb, Wolfgang4 aut |
| 700 | 1 | a Liewald, David C. M.4 aut |
| 700 | 1 | a Matsubara, Tatsuaki4 aut |
| 700 | 1 | a Matsushita, Yumi4 aut |
| 700 | 1 | a Meitinger, Thomas4 aut |
| 700 | 1 | a Mihailov, Evelin4 aut |
| 700 | 1 | a Milani, Lili4 aut |
| 700 | 1 | a Mills, Rebecca4 aut |
| 700 | 1 | a Mononen, Nina4 aut |
| 700 | 1 | a Mueller-Nurasyid, Martina4 aut |
| 700 | 1 | a Nabika, Toru4 aut |
| 700 | 1 | a Nakashima, Eitaro4 aut |
| 700 | 1 | a Ng, Hong Kiat4 aut |
| 700 | 1 | a Nikus, Kjell4 aut |
| 700 | 1 | a Nutile, Teresa4 aut |
| 700 | 1 | a Ohkubo, Takayoshi4 aut |
| 700 | 1 | a Ohnaka, Keizo4 aut |
| 700 | 1 | a Parish, Sarah4 aut |
| 700 | 1 | a Paternoster, Lavinia4 aut |
| 700 | 1 | a Peng, Hao4 aut |
| 700 | 1 | a Peters, Annette4 aut |
| 700 | 1 | a Pham, Son T.4 aut |
| 700 | 1 | a Pinidiyapathirage, Mohitha J.4 aut |
| 700 | 1 | a Rahman, Mahfuzar4 aut |
| 700 | 1 | a Rakugi, Hiromi4 aut |
| 700 | 1 | a Rolandsson, Olovu Umeå universitet,Allmänmedicin4 aut0 (Swepub:umu)olro0005 |
| 700 | 1 | a Rozario, Michelle Ann4 aut |
| 700 | 1 | a Ruggiero, Daniela4 aut |
| 700 | 1 | a Sala, Cinzia F.4 aut |
| 700 | 1 | a Sarju, Ralhan4 aut |
| 700 | 1 | a Shimokawa, Kazuro4 aut |
| 700 | 1 | a Snieder, Harold4 aut |
| 700 | 1 | a Sparso, Thomas4 aut |
| 700 | 1 | a Spiering, Wilko4 aut |
| 700 | 1 | a Starr, John M.4 aut |
| 700 | 1 | a Stott, David J.4 aut |
| 700 | 1 | a Stram, Daniel O.4 aut |
| 700 | 1 | a Sugiyama, Takao4 aut |
| 700 | 1 | a Szymczak, Silke4 aut |
| 700 | 1 | a Tang, W. H. Wilson4 aut |
| 700 | 1 | a Tong, Lin4 aut |
| 700 | 1 | a Trompet, Stella4 aut |
| 700 | 1 | a Turjanmaa, Vaino4 aut |
| 700 | 1 | a Ueshima, Hirotsugu4 aut |
| 700 | 1 | a Uitterlinden, Andre G.4 aut |
| 700 | 1 | a Umemura, Satoshi4 aut |
| 700 | 1 | a Vaarasmaki, Marja4 aut |
| 700 | 1 | a van Dam, Rob M.4 aut |
| 700 | 1 | a van Gilst, Wiek H.4 aut |
| 700 | 1 | a van Veldhuisen, Dirk J.4 aut |
| 700 | 1 | a Viikari, Jorma S.4 aut |
| 700 | 1 | a Waldenberger, Melanie4 aut |
| 700 | 1 | a Wang, Yiqin4 aut |
| 700 | 1 | a Wang, Aili4 aut |
| 700 | 1 | a Wilson, Rory4 aut |
| 700 | 1 | a Wong, Tien-Yin4 aut |
| 700 | 1 | a Xiang, Yong-Bing4 aut |
| 700 | 1 | a Yamaguchi, Shuhei4 aut |
| 700 | 1 | a Ye, Xingwang4 aut |
| 700 | 1 | a Young, Robin D.4 aut |
| 700 | 1 | a Young, Terri L.4 aut |
| 700 | 1 | a Yuan, Jian-Min4 aut |
| 700 | 1 | a Zhou, Xueya4 aut |
| 700 | 1 | a Asselbergs, Folkert W.4 aut |
| 700 | 1 | a Ciullo, Marina4 aut |
| 700 | 1 | a Clarke, Robert4 aut |
| 700 | 1 | a Deloukas, Panos4 aut |
| 700 | 1 | a Franke, Andre4 aut |
| 700 | 1 | a Franks, Paul Wu Lund University,Lunds universitet,Umeå universitet,Allmänmedicin,Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf |
| 700 | 1 | a Franks, Steve4 aut |
| 700 | 1 | a Friedlander, Yechiel4 aut |
| 700 | 1 | a Gross, Myron D.4 aut |
| 700 | 1 | a Guo, Zhirong4 aut |
| 700 | 1 | a Hansen, Torben4 aut |
| 700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
| 700 | 1 | a Jorgensen, Torben4 aut |
| 700 | 1 | a Jukema, J. Wouter4 aut |
| 700 | 1 | a Kahonen, Mika4 aut |
| 700 | 1 | a Kajio, Hiroshi4 aut |
| 700 | 1 | a Kivimaki, Mika4 aut |
| 700 | 1 | a Lee, Jong-Young4 aut |
| 700 | 1 | a Lehtimaki, Terho4 aut |
| 700 | 1 | a Linneberg, Allan4 aut |
| 700 | 1 | a Miki, Tetsuro4 aut |
| 700 | 1 | a Pedersen, Oluf4 aut |
| 700 | 1 | a Samani, Nilesh J.4 aut |
| 700 | 1 | a Sorensen, Thorkild I. A.4 aut |
| 700 | 1 | a Takayanagi, Ryoichi4 aut |
| 700 | 1 | a Toniolo, Daniela4 aut |
| 700 | 1 | a Ahsan, Habibul4 aut |
| 700 | 1 | a Allayee, Hooman4 aut |
| 700 | 1 | a Chen, Yuan-Tsong4 aut |
| 700 | 1 | a Danesh, John4 aut |
| 700 | 1 | a Deary, Ian J.4 aut |
| 700 | 1 | a Franco, Oscar H.4 aut |
| 700 | 1 | a Franke, Lude4 aut |
| 700 | 1 | a Heijman, Bastiaan T.4 aut |
| 700 | 1 | a Holbrook, Joanna D.4 aut |
| 700 | 1 | a Isaacs, Aaron4 aut |
| 700 | 1 | a Kim, Bong-Jo4 aut |
| 700 | 1 | a Lin, Xu4 aut |
| 700 | 1 | a Liu, Jianjun4 aut |
| 700 | 1 | a Maerz, Winfried4 aut |
| 700 | 1 | a Metspalu, Andres4 aut |
| 700 | 1 | a Mohlke, Karen L.4 aut |
| 700 | 1 | a Sanghera, Dharambir K.4 aut |
| 700 | 1 | a Shu, Xiao-Ou4 aut |
| 700 | 1 | a van Meurs, Joyce B. J.4 aut |
| 700 | 1 | a Vithana, Eranga4 aut |
| 700 | 1 | a Wickremasinghe, Ananda R.4 aut |
| 700 | 1 | a Wijmenga, Cisca4 aut |
| 700 | 1 | a Wolffenbuttel, Bruce H. W.4 aut |
| 700 | 1 | a Yokota, Mitsuhiro4 aut |
| 700 | 1 | a Zheng, Wei4 aut |
| 700 | 1 | a Zhu, Dingliang4 aut |
| 700 | 1 | a Vineis, Paolo4 aut |
| 700 | 1 | a Kyrtopoulos, Soterios A.4 aut |
| 700 | 1 | a Kleinjans, Jos C. S.4 aut |
| 700 | 1 | a McCarthy, Mark I.4 aut |
| 700 | 1 | a Soong, Richie4 aut |
| 700 | 1 | a Gieger, Christian4 aut |
| 700 | 1 | a Scott, James4 aut |
| 700 | 1 | a Teo, Yik-Ying4 aut |
| 700 | 1 | a He, Jiang4 aut |
| 700 | 1 | a Elliott, Paul4 aut |
| 700 | 1 | a Tai, E. Shyong4 aut |
| 700 | 1 | a van der Harst, Pim4 aut |
| 700 | 1 | a Kooner, Jaspal S.4 aut |
| 700 | 1 | a Chambers, John C.4 aut |
| 710 | 2 | a Genetisk och molekylär epidemiologib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Nature Geneticsd : Nature Publishing Groupg 47:11, s. 1282-1293q 47:11<1282-1293x 1061-4036x 1546-1718 |
| 856 | 4 | u https://europepmc.org/articles/pmc4719169?pdf=render |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/26390057?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1038/ng.3405y FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-111999 |
| 856 | 4 8 | u https://doi.org/10.1038/ng.3405 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/8035521 |
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